Entity Details

Primary name ZNT10_HUMAN
Entity type UniProt
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Details

AccessionQ6XR72
EntryNameZNT10_HUMAN
FullNameZinc transporter 10
TaxID9606
Evidenceevidence at protein level
Length485
SequenceStatuscomplete
DateCreated2007-12-04
DateModified2021-06-02

Ontological Relatives

GenesSLC30A10

GO terms

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GOName
GO:0005385 zinc ion transmembrane transporter activity
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0006828 manganese ion transport
GO:0006882 cellular zinc ion homeostasis
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0010312 detoxification of zinc ion
GO:0016021 integral component of membrane
GO:0043524 negative regulation of neuron apoptotic process
GO:0055037 recycling endosome
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071421 manganese ion transmembrane transport
GO:0071577 zinc ion transmembrane transport
GO:0071579 regulation of zinc ion transport
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1904385 cellular response to angiotensin
GO:1905802 regulation of cellular response to manganese ion
GO:2000773 negative regulation of cellular senescence

Subcellular Location

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Subcellular Location
Cell membrane
Early endosome
Golgi apparatus
Recycling endosome

Domains

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DomainNameCategoryType
IPR002524 Cation efflux proteinFamilyFamily
IPR027469 Cation efflux transmembrane domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
613280 OMIMHypermanganesemia with dystonia 1 (HMNDYT1)A metabolic autosomal recessive disorder characterized by dystonia, parkinsonism, extrapyramidal signs, severe hypermanganesemia, polycythemia, and chronic hepatic disease, including steatosis and cirrhosis. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

6 interactions