Entity Details

Primary name XRN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IZH2
EntryNameXRN1_HUMAN
FullName5'-3' exoribonuclease 1
TaxID9606
Evidenceevidence at protein level
Length1706
SequenceStatuscomplete
DateCreated2005-12-20
DateModified2021-06-02

Ontological Relatives

GenesXRN1

GO terms

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GOName
GO:0000932 P-body
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0002151 G-quadruplex RNA binding
GO:0003723 RNA binding
GO:0004534 5'-3' exoribonuclease activity
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016075 rRNA catabolic process
GO:0017148 negative regulation of translation
GO:0030425 dendrite
GO:0032211 negative regulation of telomere maintenance via telomerase
GO:0033574 response to testosterone
GO:0043025 neuronal cell body
GO:0043488 regulation of mRNA stability
GO:0045202 synapse
GO:0051880 G-quadruplex DNA binding
GO:0070034 telomerase RNA binding
GO:0071028 nuclear mRNA surveillance
GO:0071044 histone mRNA catabolic process
GO:0071409 cellular response to cycloheximide
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1905795 cellular response to puromycin

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR004859 Putative 5-3 exonucleaseDomainDomain
IPR016494 5'-3' exoribonuclease 1FamilyFamily
IPR027073 5'-3' exoribonucleaseFamilyFamily
IPR040992 Xrn1, D1 domainDomainDomain
IPR041106 Exoribonuclease Xrn1, D2/D3 domainDomainDomain
IPR041385 5'-3' exoribonuclease 1, SH3-like domainDomainDomain
IPR041412 Xrn1, helical domainDomainDomain

Diseases

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Interactions

105 interactions

InteractorPartnerSourcesPublicationsLink
XRN1_HUMANBAG6_HUMANBioGRID, HPRD, IntAct15231747 26496610 details
XRN1_HUMANLDHA_HUMANBioGRID, HPRD, IntAct15231747 details
XRN1_HUMANPABP4_HUMANBioGRID, HPRD, IntAct15231747 details
XRN1_HUMANVW5B2_HUMANBioGRID, IntAct15231747 details
XRN1_HUMANALDOA_HUMANBioGRID, HPRD, IntAct15231747 details
XRN1_HUMANAP1G2_HUMANBioGRID, IntAct15231747 details
XRN1_HUMANSTAM2_HUMANBioGRID, HPRD, IntAct15231747 details
XRN1_HUMANCHD4_HUMANBioGRID, HPRD, IntAct15231747 details
XRN1_HUMANSMRD2_HUMANBioGRID, HPRD, IntAct15231747 details
XRN1_HUMANTCPE_HUMANBioGRID, HPRD, IntAct15231747 details
XRN1_HUMANNDUAD_HUMANBioGRID, HPRD, IntAct15231747 details
XRN1_HUMANHEAT1_HUMANBioGRID, IntAct15231747 details
XRN1_HUMANSPT20_HUMANBioGRID, HPRD, IntAct15231747 details
XRN1_HUMANROA1_HUMANBioGRID, HPRD, IntAct15231747 details
XRN1_HUMANWAPL_HUMANBioGRID, HPRD, IntAct15231747 details
XRN1_HUMANDPP2_HUMANBioGRID, HPRD, IntAct15231747 details
XRN1_HUMANDCP1A_HUMANBioGRID, IntAct15231747 16364915 27315556 29395067 details
XRN1_HUMANLSM4_HUMANBioGRID, HPRD15231747 details
XRN1_HUMANSKIV2_HUMANBioGRID, HPRD15231747 details
XRN1_HUMANNDUBA_HUMANBioGRID15231747 details
XRN1_HUMANNDUB9_HUMANBioGRID15231747 details
XRN1_HUMANPP2AA_HUMANBioGRID15231747 details
XRN1_HUMANPSB5_HUMANBioGRID15231747 details
XRN1_HUMANKTNB1_HUMANBioGRID15231747 details
XRN1_HUMANDPOD2_HUMANBioGRID15231747 details
XRN1_HUMANMA2C1_HUMANBioGRID15231747 details
XRN1_HUMANFADS1_HUMANBioGRID15231747 details
XRN1_HUMANTM50A_HUMANBioGRID15231747 details
XRN1_HUMANMTCH2_HUMANBioGRID15231747 details
XRN1_HUMANSRRM2_HUMANBioGRID15231747 details
XRN1_HUMANC1GLT_HUMANBioGRID15231747 details
XRN1_HUMANANGL6_HUMANBioGRID15231747 details
XRN1_HUMANPADC1_HUMANBioGRID15231747 details
XRN1_HUMANMFSD5_HUMANBioGRID15231747 details
XRN1_HUMANAGRE5_HUMANBioGRID15231747 details
XRN1_HUMANB3GT6_HUMANBioGRID15231747 details
XRN1_HUMANGLMP_HUMANBioGRID15231747 details
XRN1_HUMANCBX5_HUMANBioGRID15231747 details
XRN1_HUMANPKHG2_HUMANBioGRID15231747 details
XRN1_HUMANRBMX_HUMANBioGRID15231747 details
XRN1_HUMANRN187_HUMANBioGRID15231747 details
XRN1_HUMANLEPR_HUMANBioGRID15231747 details
XRN1_HUMANCATH_HUMANBioGRID15231747 details
XRN1_HUMANAT5G2_HUMANBioGRID15231747 details
XRN1_HUMANDNS2A_HUMANBioGRID15231747 details
XRN1_HUMANSDHB_HUMANBioGRID15231747 details
XRN1_HUMANLG3BP_HUMANBioGRID15231747 details
XRN1_HUMANCATB_HUMANBioGRID15231747 details
XRN1_HUMANEXOS8_HUMANBioGRID, HPRD15231747 details
XRN1_HUMANDXO_HUMANBioGRID, HPRD15231747 details
XRN1_HUMANEXOS6_HUMANBioGRID, HPRD15231747 details
XRN1_HUMANDCP1B_HUMANBioGRID, HPRD15231747 29395067 details
XRN1_HUMANEXOSX_HUMANBioGRID, HPRD15231747 details
XRN1_HUMANTTP_HUMANBioGRID, HPRD15231747 21964062 details
XRN1_HUMANMTREX_HUMANBioGRID, HPRD15231747 details
XRN1_HUMANEXOS1_HUMANBioGRID, HPRD15231747 details
XRN1_HUMANFBX7_HUMANBioGRID27503909 details
XRN1_HUMANCENP1_HUMANHPRD15231747 details
XRN1_HUMANRENT1_HUMANBioGRID, HPRD, IntAct14527413 18423202 21145460 29395067 details
XRN1_HUMANZCCHV_HUMANDIP21876179 details
XRN1_HUMANRENT2_HUMANBioGRID, HPRD14527413 details
XRN1_HUMANREN3A_HUMANBioGRID14527413 details
XRN1_HUMANMLH1_HUMANBioGRID17148452 details
XRN1_HUMANDYR1A_HUMANBioGRID29395067 30773093 details
XRN1_HUMANAGO1_HUMANBioGRID29395067 details
XRN1_HUMANAGO2_HUMANBioGRID29395067 details
XRN1_HUMANALG13_HUMANBioGRID29395067 details
XRN1_HUMANCP131_HUMANBioGRID29395067 details
XRN1_HUMANCE192_HUMANBioGRID29395067 details
XRN1_HUMANCNOT1_HUMANBioGRID29395067 details
XRN1_HUMANEDC3_HUMANBioGRID29395067 details
XRN1_HUMANEDC4_HUMANBioGRID29395067 details
XRN1_HUMAN4ET_HUMANBioGRID29395067 details
XRN1_HUMANFUBP3_HUMANBioGRID29395067 details
XRN1_HUMANGTPB1_HUMANBioGRID29395067 details
XRN1_HUMANHELZ_HUMANBioGRID29395067 details
XRN1_HUMANIF2B2_HUMANBioGRID29395067 details
XRN1_HUMANMARF1_HUMANBioGRID29395067 details
XRN1_HUMANTGO1_HUMANBioGRID29395067 details
XRN1_HUMANOFD1_HUMANBioGRID29395067 details
XRN1_HUMANOTUD4_HUMANBioGRID29395067 details
XRN1_HUMANPATL1_HUMANBioGRID29395067 details
XRN1_HUMANPRC2A_HUMANBioGRID29395067 details
XRN1_HUMANPRC2B_HUMANBioGRID29395067 details
XRN1_HUMANR3HD1_HUMANBioGRID29395067 details
XRN1_HUMANRBMS1_HUMANBioGRID29395067 details
XRN1_HUMANRC3H1_HUMANBioGRID29395067 details
XRN1_HUMANSC16A_HUMANBioGRID29395067 details
XRN1_HUMANSMG7_HUMANBioGRID29395067 details
XRN1_HUMANTDRD3_HUMANBioGRID29395067 details
XRN1_HUMANTNR6B_HUMANBioGRID29395067 details
XRN1_HUMANTOP3B_HUMANBioGRID29395067 details
XRN1_HUMANYTDC2_HUMANBioGRID29395067 details
XRN1_HUMANYTHD2_HUMANBioGRID29395067 details
XRN1_HUMANATX2_HUMANBioGRID29395067 details
XRN1_HUMANCPEB4_HUMANBioGRID29395067 details
XRN1_HUMANLS14A_HUMANBioGRID29395067 details
XRN1_HUMANR3HD2_HUMANBioGRID29395067 details
XRN1_HUMANSMG5_HUMANBioGRID29395067 details
XRN1_HUMANTUT4_HUMANBioGRID29395067 details
XRN1_HUMANDI3L2_HUMANBioGRID29395067 details
XRN1_HUMANPUM2_HUMANBioGRID29395067 details
XRN1_HUMANSEBP2_HUMANBioGRID29395067 details
XRN1_HUMANEST1A_HUMANBioGRID29395067 details
XRN1_HUMANREN3B_HUMANHPRD14527413 details