Entity Details

Primary name DVL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14640
EntryNameDVL1_HUMAN
FullNameSegment polarity protein dishevelled homolog DVL-1
TaxID9606
Evidenceevidence at protein level
Length695
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesDVL1

GO terms

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GOName
GO:0001505 regulation of neurotransmitter levels
GO:0001934 positive regulation of protein phosphorylation
GO:0005109 frizzled binding
GO:0005829 cytosol
GO:0005874 microtubule
GO:0006355 regulation of transcription, DNA-templated
GO:0006469 negative regulation of protein kinase activity
GO:0007269 neurotransmitter secretion
GO:0007411 axon guidance
GO:0007528 neuromuscular junction development
GO:0008013 beta-catenin binding
GO:0010976 positive regulation of neuron projection development
GO:0014069 postsynaptic density
GO:0016328 lateral plasma membrane
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0021915 neural tube development
GO:0022007 convergent extension involved in neural plate elongation
GO:0030136 clathrin-coated vesicle
GO:0030426 growth cone
GO:0031122 cytoplasmic microtubule organization
GO:0031267 small GTPase binding
GO:0031410 cytoplasmic vesicle
GO:0032091 negative regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504 protein localization to nucleus
GO:0035176 social behavior
GO:0035372 protein localization to microtubule
GO:0035556 intracellular signal transduction
GO:0035567 non-canonical Wnt signaling pathway
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043113 receptor clustering
GO:0043197 dendritic spine
GO:0045202 synapse
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048668 collateral sprouting
GO:0048675 axon extension
GO:0048813 dendrite morphogenesis
GO:0050808 synapse organization
GO:0050821 protein stabilization
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060134 prepulse inhibition
GO:0060997 dendritic spine morphogenesis
GO:0071340 skeletal muscle acetylcholine-gated channel clustering
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090103 cochlea morphogenesis
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098793 presynapse
GO:0098978 glutamatergic synapse
GO:0099054 presynapse assembly
GO:0150012 positive regulation of neuron projection arborization
GO:1903827 regulation of cellular protein localization
GO:1904886 beta-catenin destruction complex disassembly
GO:1905386 positive regulation of protein localization to presynapse
GO:1990909 Wnt signalosome
GO:2000300 regulation of synaptic vesicle exocytosis
GO:2000463 positive regulation of excitatory postsynaptic potential

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Cytoplasmic vesicle

Domains

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DomainNameCategoryType
IPR000591 DEP domainDomainDomain
IPR001158 DIX domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR003351 Dishevelled protein domainDomainDomain
IPR008339 Dishevelled familyFamilyFamily
IPR008340 Dishevelled-1FamilyFamily
IPR015506 Dishevelled-related proteinFamilyFamily
IPR024580 Dishevelled C-terminalDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR038207 DIX domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
DVL1_HUMANUBP13_HUMANBioGRID, HPRD, IntAct16169070 details
DVL1_HUMANPSA3_HUMANBioGRID, IntAct21988832 details
DVL1_HUMANSIPA1_HUMANBioGRID, IntAct21988832 details
DVL1_HUMANANXA7_HUMANBioGRID, MINT21900206 details
DVL1_HUMANDAAM1_HUMANHPRD, MINT11779461 22705156 details
DVL1_HUMANLRRK2_HUMANBioGRID, IntAct19625296 details
DVL1_HUMANKC1E_HUMANBioGRID, HPRD, IntAct11425858 11487578 11818547 details
DVL1_HUMANDVL3_HUMANbhf-ucl, BioGRID, HPRD10330181 32296183 details
DVL1_HUMANBUB1_HUMANBioGRID, MINT24412244 details
DVL1_HUMANFBXW7_HUMANBioGRID, MINT24412244 details
DVL1_HUMANMLH3_HUMANBioGRID, MINT24412244 details
DVL1_HUMANMSH2_HUMANBioGRID, MINT24412244 details
DVL1_HUMANRB_HUMANBioGRID, MINT24412244 details
DVL1_HUMANSCYL2_HUMANbhf-ucl19643732 details
DVL1_HUMANEPS8_HUMANBioGRID, HPRD10581192 details
DVL1_HUMANHECW1_HUMANBioGRID, HPRD14684739 details
DVL1_HUMANDAB2_HUMANBioGRID12805222 details
DVL1_HUMANSMAD1_HUMANBioGRID12650946 details
DVL1_HUMANSMAD2_HUMANBioGRID, HPRD12650946 details
DVL1_HUMANSMAD3_HUMANBioGRID, HPRD12650946 details
DVL1_HUMANSMAD4_HUMANBioGRID, HPRD12650946 details
DVL1_HUMANSMAD7_HUMANBioGRID, HPRD12650946 details
DVL1_HUMANAXIN1_HUMANBioGRID, HPRD10330403 10428961 12556519 18632848 9482734 details
DVL1_HUMANATN1_HUMANBioGRID10332026 details
DVL1_HUMANKC1D_HUMANBioGRID, HPRD11818547 details
DVL1_HUMANNEDD4_HUMANBioGRID22467858 details
DVL1_HUMANNCK2_HUMANBioGRID25416956 details
DVL1_HUMANTRI69_HUMANBioGRID25416956 details
DVL1_HUMANSMYD1_HUMANBioGRID32296183 details
DVL1_HUMANKLH12_HUMANBioGRID32296183 32574548 details
DVL1_HUMANBAG3_HUMANBioGRID32296183 details
DVL1_HUMANBRD7_HUMANHPRD12941796 details
DVL1_HUMANVANG1_HUMANHPRD15456783 details
DVL1_HUMANPPM1A_HUMANHPRD10644691 details
DVL1_HUMANDYLT1_HUMANHPRD10644691 details
DVL1_HUMANHDHD2_HUMANHPRD16169070 details
DVL1_HUMANDAPLE_HUMANHPRD14750955 details
DVL1_HUMANARHGJ_HUMANMINT18256687 details
DVL1_HUMANAPC_HUMANIntAct, MINT11425858 20224554 details
DVL1_HUMANDVL2_HUMANBioGRID, MINT20224554 24643799 26186194 28514442 31340145 details
DVL1_HUMANTFDP1_HUMANMINT22773187 details
DVL1_HUMANCTNB1_HUMANBioGRID, HPRD, IntAct10806215 25241761 details
DVL1_HUMANCSK21_HUMANBioGRID, HPRD, IntAct10806215 25241761 details
DVL1_HUMANDVL1_HUMANbhf-ucl, BioGRID, HPRD10330181 details
DVL1_HUMANWWTR1_HUMANbhf-ucl, BioGRID20412773 details
DVL1_HUMANNKD2_HUMANbhf-ucl, BioGRID20177058 details
DVL1_HUMANSIR1_HUMANBioGRID, DIP20439735 details
DVL1_HUMANARRB1_HUMANBioGRID, HPRD11742073 details
DVL1_HUMANFRAT1_HUMANBioGRID, HPRD10428961 details
DVL1_HUMANCYLD_HUMANBioGRID20227366 details
DVL1_HUMANSDC4_HUMANBioGRID20639201 details
DVL1_HUMANITCH_HUMANBioGRID22826439 details
DVL1_HUMANHUWE1_HUMANBioGRID24643799 details
DVL1_HUMANNUMA1_HUMANBioGRID24469800 details
DVL1_HUMANSTAU1_HUMANBioGRID29395067 details
DVL1_HUMANVANG2_HUMANHPRD12490194 details
DVL1_HUMANRAC1_HUMANHPRD12533515 details