Entity Details

Primary name DCE1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99259
EntryNameDCE1_HUMAN
FullNameGlutamate decarboxylase 1
TaxID9606
Evidenceevidence at protein level
Length594
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesGAD1

GO terms

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GOName
GO:0004351 glutamate decarboxylase activity
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0006538 glutamate catabolic process
GO:0006540 glutamate decarboxylation to succinate
GO:0007268 chemical synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0009449 gamma-aminobutyric acid biosynthetic process
GO:0012506 vesicle membrane
GO:0016595 glutamate binding
GO:0018352 protein-pyridoxal-5-phosphate linkage
GO:0030170 pyridoxal phosphate binding
GO:0035176 social behavior
GO:0035641 locomotory exploration behavior
GO:0042136 neurotransmitter biosynthetic process
GO:0042493 response to drug
GO:0043679 axon terminus
GO:0044877 protein-containing complex binding
GO:0047485 protein N-terminus binding
GO:0048786 presynaptic active zone
GO:0060077 inhibitory synapse
GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane

Subcellular Location

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Domains

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DomainNameCategoryType
IPR002129 Pyridoxal phosphate-dependent decarboxylaseFamilyFamily
IPR015421 Pyridoxal phosphate-dependent transferase, major domainFamilyHomologous superfamily
IPR015424 Pyridoxal phosphate-dependent transferaseFamilyHomologous superfamily
IPR021115 Pyridoxal-phosphate binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB00114 Pyridoxal phosphateDrugbanksmall molecule
DB00142 Glutamic acidDrugbanksmall molecule