Entity Details

Primary name NKX31_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99801
EntryNameNKX31_HUMAN
FullNameHomeobox protein Nkx-3.1
TaxID9606
Evidenceevidence at protein level
Length234
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesNKX3-1

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001656 metanephros development
GO:0001756 somitogenesis
GO:0001934 positive regulation of protein phosphorylation
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007275 multicellular organism development
GO:0007431 salivary gland development
GO:0007507 heart development
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008584 male gonad development
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010942 positive regulation of cell death
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030154 cell differentiation
GO:0030284 estrogen receptor activity
GO:0030331 estrogen receptor binding
GO:0030521 androgen receptor signaling pathway
GO:0032880 regulation of protein localization
GO:0033574 response to testosterone
GO:0035690 cellular response to drug
GO:0035907 dorsal aorta development
GO:0042826 histone deacetylase binding
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043491 protein kinase B signaling
GO:0043565 sequence-specific DNA binding
GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway
GO:0043621 protein self-association
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051781 positive regulation of cell division
GO:0060037 pharyngeal system development
GO:0060442 branching involved in prostate gland morphogenesis
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071383 cellular response to steroid hormone stimulus
GO:0071456 cellular response to hypoxia
GO:0071899 obsolete negative regulation of estrogen receptor binding
GO:0090734 site of DNA damage
GO:0097162 MADS box domain binding
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000836 positive regulation of androgen secretion
GO:2001022 positive regulation of response to DNA damage stimulus
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site
IPR020479 Homeobox domain, metazoaDomainDomain

Diseases

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Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
NKX31_HUMANTOP1_HUMANBioGRID, DIP, IntAct17234752 27339988 details
NKX31_HUMANZN417_HUMANBioGRID, IntAct32296183 details
NKX31_HUMANMO2R2_HUMANBioGRID, IntAct32296183 details
NKX31_HUMANRNF4_HUMANBioGRID, IntAct32296183 details
NKX31_HUMANS22AI_HUMANBioGRID, IntAct32296183 details
NKX31_HUMANRHXF2_HUMANBioGRID, IntAct32296183 details
NKX31_HUMANSPDEF_HUMANBioGRID, HPRD11809674 18816836 details
NKX31_HUMANSP1_HUMANBioGRID16201967 details
NKX31_HUMANSP2_HUMANBioGRID16201967 details
NKX31_HUMANSP3_HUMANBioGRID16201967 details
NKX31_HUMANSP4_HUMANBioGRID16201967 details
NKX31_HUMANSP5_HUMANBioGRID16201967 details
NKX31_HUMANTOPRS_HUMANBioGRID18077445 details
NKX31_HUMANMEP50_HUMANBioGRID12972618 details
NKX31_HUMANROA0_HUMANBioGRID18816836 details
NKX31_HUMANMAT1_HUMANBioGRID18816836 details
NKX31_HUMANAEN_HUMANBioGRID18816836 details
NKX31_HUMANLMCD1_HUMANBioGRID18816836 details
NKX31_HUMANTX264_HUMANBioGRID18816836 details
NKX31_HUMANTCPH_HUMANBioGRID18816836 details
NKX31_HUMANRL37A_HUMANBioGRID18816836 details
NKX31_HUMANFEM1B_HUMANBioGRID18816836 details
NKX31_HUMANCHSS2_HUMANBioGRID18816836 details
NKX31_HUMANCKAP4_HUMANBioGRID18816836 details
NKX31_HUMANRABL6_HUMANBioGRID18816836 details
NKX31_HUMANMA2B1_HUMANBioGRID18816836 details
NKX31_HUMANNU4M_HUMANBioGRID18816836 details
NKX31_HUMANHM20B_HUMANBioGRID18816836 details
NKX31_HUMANPEBP1_HUMANBioGRID18816836 details
NKX31_HUMANPTMS_HUMANBioGRID18816836 details
NKX31_HUMANCENPX_HUMANBioGRID18816836 details
NKX31_HUMANRARG_HUMANBioGRID18816836 details
NKX31_HUMANRSSA_HUMANBioGRID18816836 details
NKX31_HUMANSTMN3_HUMANBioGRID18816836 details
NKX31_HUMANENPL_HUMANBioGRID18816836 details
NKX31_HUMANTCTP_HUMANBioGRID18816836 details
NKX31_HUMANEHMT2_HUMANDIP27339988 details
NKX31_HUMANSRF_HUMANBioGRID, HPRD10993896 details
NKX31_HUMANHDAC1_HUMANBioGRID16697957 details
NKX31_HUMANKAT2B_HUMANBioGRID17602165 details
NKX31_HUMANHIPK2_HUMANHPRD10559189 details