Entity Details

Primary name P73_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15350
EntryNameP73_HUMAN
FullNameTumor protein p73
TaxID9606
Evidenceevidence at protein level
Length636
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesTP73

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001822 kidney development
GO:0002039 p53 binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006298 mismatch repair
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006974 cellular response to DNA damage stimulus
GO:0007346 regulation of mitotic cell cycle
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell population proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010243 response to organonitrogen compound
GO:0010468 regulation of gene expression
GO:0016032 viral process
GO:0019901 protein kinase binding
GO:0030054 cell junction
GO:0042493 response to drug
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0045665 negative regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0051262 protein tetramerization
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0097371 MDM2/MDM4 family protein binding
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1902036 regulation of hematopoietic stem cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001660 Sterile alpha motif domainDomainDomain
IPR002117 p53 tumour suppressor familyFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR010991 p53, tetramerisation domainDomainDomain
IPR011615 p53, DNA-binding domainDomainDomain
IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR032646 Tumour protein p73FamilyFamily
IPR036674 p53-like tetramerisation domain superfamilyFamilyHomologous superfamily
IPR037612 Tumour protein p73, SAM domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

107 interactions

InteractorPartnerSourcesPublicationsLink
P73_HUMANEP300_HUMANBioGRID, DIP, HPRD, MINT10648616 11804596 15175157 15454570 15893728 18663001 19218448 25675294 details
P73_HUMANASPP1_HUMANHPRD, MINT14729977 details
P73_HUMANCEBPZ_HUMANBioGRID, HPRD, MINT12534345 details
P73_HUMANHMGB1_HUMANBioGRID, HPRD, IntAct11748232 details
P73_HUMANWWOX_HUMANBioGRID, HPRD, MINT15070730 24550385 details
P73_HUMANITCH_HUMANBioGRID, DIP, HPRD, MINT15678106 17110958 17592138 30603043 32513985 details
P73_HUMANYAP1_HUMANBioGRID, HPRD, MINT11278685 15893728 17110958 18280240 18640976 19111660 25283809 27292796 31496812 details
P73_HUMANABL1_HUMANBioGRID, HPRD, MINT10391250 10391251 11278685 19442657 25893286 details
P73_HUMANSIR1_HUMANBioGRID, UniProt16998810 details
P73_HUMANAURKA_HUMANBioGRID, IntAct22340593 details
P73_HUMANP73_HUMANBioGRID, DIP, HPRD, IntAct10373484 10961991 11389695 19815500 22340593 22474346 9802988 details
P73_HUMANMDM4_HUMANBioGRID, HPRD, IntAct11223036 21088494 28514442 29523541 30603043 details
P73_HUMANP63_HUMANBioGRID, DIP, HPRD, IntAct10373484 11238924 17446929 19815500 22252508 28514442 details
P73_HUMANASPP2_HUMANDIP18275817 details
P73_HUMANIASPP_HUMANDIP18275817 details
P73_HUMANMDM2_HUMANBioGRID, DIP, HPRD10207051 10321734 10435614 10469568 11223036 18499675 19218448 20588255 21088494 21261729 25301064 25417702 26025930 30603043 details
P73_HUMANRACK1_HUMANBioGRID, HPRD12761493 details
P73_HUMANSUMO1_HUMANBioGRID, HPRD10961991 details
P73_HUMANUBC9_HUMANBioGRID10961991 details
P73_HUMANCHD3_HUMANBioGRID, HPRD10961991 details
P73_HUMANHIPK3_HUMANBioGRID10961991 details
P73_HUMANTDG_HUMANBioGRID10961991 18951877 details
P73_HUMANHIPK2_HUMANBioGRID, HPRD11925430 details
P73_HUMANMYC_HUMANBioGRID, HPRD11844794 12080043 details
P73_HUMANIKKA_HUMANBioGRID17452332 21482671 details
P73_HUMANRANB9_HUMANBioGRID15558019 details
P73_HUMANHECW2_HUMANBioGRID, HPRD12890487 details
P73_HUMANHDAC1_HUMANBioGRID15454570 17353261 details
P73_HUMANFBSP1_HUMANBioGRID19581926 details
P73_HUMANCBP_HUMANBioGRID, HPRD10648616 11279015 details
P73_HUMANAMPH_HUMANBioGRID11709703 details
P73_HUMANIKKB_HUMANBioGRID21482671 details
P73_HUMANDAXX_HUMANBioGRID12954772 15339933 details
P73_HUMANBUB1B_HUMANBioGRID19139399 details
P73_HUMANPIN1_HUMANBioGRID15175157 details
P73_HUMANKAT2B_HUMANBioGRID, HPRD14614455 18663001 details
P73_HUMANZN363_HUMANBioGRID21994467 details
P73_HUMANDDB1_HUMANBioGRID23085759 details
P73_HUMANCDK2_HUMANBioGRID, HPRD12676926 details
P73_HUMANCCNA2_HUMANBioGRID12676926 details
P73_HUMANCCNE1_HUMANBioGRID12676926 details
P73_HUMANCCNB1_HUMANBioGRID12676926 details
P73_HUMANCCND1_HUMANBioGRID12676926 details
P73_HUMANXPO1_HUMANBioGRID22833565 details
P73_HUMANPFD5_HUMANBioGRID, HPRD11844794 details
P73_HUMANPLAL1_HUMANBioGRID18663001 details
P73_HUMANP53_HUMANBioGRID, HPRD11238924 21508668 25417702 9802988 9891077 details
P73_HUMANRL11_HUMANBioGRID25301064 details
P73_HUMANRL5_HUMANBioGRID25301064 details
P73_HUMANMUL1_HUMANBioGRID26435500 details
P73_HUMANWWP2_HUMANBioGRID25071155 31048545 details
P73_HUMANCSK21_HUMANBioGRID25379016 details
P73_HUMANTIF1B_HUMANBioGRID25893286 details
P73_HUMANKPCD_HUMANBioGRID12097319 15723830 details
P73_HUMANATF3_HUMANBioGRID18644986 details
P73_HUMANSP1_HUMANBioGRID15790310 details
P73_HUMANSP3_HUMANBioGRID15790310 details
P73_HUMANHCK_HUMANBioGRID17535448 details
P73_HUMANKAPCB_HUMANBioGRID15723830 details
P73_HUMANCDK1_HUMANBioGRID, HPRD12676926 12920125 details
P73_HUMANFLNA_HUMANBioGRID17825253 details
P73_HUMANPIAS1_HUMANBioGRID, HPRD15572666 details
P73_HUMANPLK1_HUMANBioGRID18174154 details
P73_HUMANCHIP_HUMANBioGRID30714204 details
P73_HUMANBIN1_HUMANHPRD11709703 details
P73_HUMANRASH_HUMANHPRD16436381 details
P73_HUMANCCNT1_HUMANBioGRID, MINT16135803 details
P73_HUMANNEDD4_HUMANBioGRID, HPRD, MINT15678106 details
P73_HUMANUBC_HUMANMINT15678106 details
P73_HUMANRB_HUMANBioGRID, IntAct12761493 19249677 details
P73_HUMANGRP75_HUMANBioGRID, IntAct22340593 details
P73_HUMANMD2L1_HUMANBioGRID, IntAct22340593 details
P73_HUMANC8AP2_HUMANI2D21725362 details
P73_HUMANRUNX2_HUMANMINT25331851 details
P73_HUMANMAGA2_HUMANDIP16847267 details
P73_HUMANPMS2_HUMANDIP18768816 details
P73_HUMANR144B_HUMANDIP20615966 details
P73_HUMANSIAH1_HUMANDIP25774835 details
P73_HUMANNFYB_HUMANBioGRID, HPRD12167641 15454570 details
P73_HUMANNFYC_HUMANBioGRID12167641 15454570 details
P73_HUMANUBE4B_HUMANBioGRID16170377 details
P73_HUMANKDM1A_HUMANBioGRID18573881 details
P73_HUMANCCNG1_HUMANBioGRID12642871 details
P73_HUMANHDAC2_HUMANBioGRID17353261 details
P73_HUMANCUL1_HUMANBioGRID19581926 details
P73_HUMANKAT5_HUMANBioGRID18499675 details
P73_HUMANBRCA1_HUMANBioGRID20807817 details
P73_HUMANACK1_HUMANBioGRID15175157 details
P73_HUMANKAPCA_HUMANBioGRID22340593 details
P73_HUMANTRI32_HUMANBioGRID23828567 details
P73_HUMANOAZ1_HUMANBioGRID20185758 details
P73_HUMANRS14_HUMANBioGRID25301064 details
P73_HUMANMED15_HUMANBioGRID25893286 details
P73_HUMANHIF1A_HUMANBioGRID25535359 details
P73_HUMANJUN_HUMANBioGRID26018080 details
P73_HUMANDAPK2_HUMANBioGRID28978663 details
P73_HUMANCDN1A_HUMANBioGRID15572666 details
P73_HUMANHSP74_HUMANBioGRID11238924 details
P73_HUMANNQO1_HUMANBioGRID28291250 details
P73_HUMANGLSL_HUMANBioGRID24121663 details
P73_HUMANSOCS1_HUMANBioGRID31101761 details
P73_HUMANWT1_HUMANHPRD10744705 details
P73_HUMANCABL1_HUMANHPRD11706030 details
P73_HUMANPML_HUMANHPRD11832207 details
P73_HUMANSMAD2_HUMANHPRD12732139 details
P73_HUMANSMAD3_HUMANHPRD12732139 details
P73_HUMANMK08_HUMANHPRD15483136 details