Entity Details

Primary name RN146_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NTX7
EntryNameRN146_HUMAN
FullNameE3 ubiquitin-protein ligase RNF146
TaxID9606
Evidenceevidence at protein level
Length359
SequenceStatuscomplete
DateCreated2005-03-01
DateModified2021-06-02

Ontological Relatives

GenesRNF146

GO terms

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GOName
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008270 zinc ion binding
GO:0016055 Wnt signaling pathway
GO:0051865 protein autoubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:0070936 protein K48-linked ubiquitination
GO:0072572 poly-ADP-D-ribose binding
GO:0090263 positive regulation of canonical Wnt signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR004170 WWE domainDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR018123 WWE domain, subgroupDomainDomain
IPR033509 E3 ubiquitin-protein ligase RNF146FamilyFamily
IPR037197 WWE domain superfamilyFamilyHomologous superfamily
IPR044110 RNF146, RING finger, HC subclassDomainDomain

Diseases

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Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
RN146_HUMANPROF2_HUMANBioGRID, HPRD, IntAct16169070 details
RN146_HUMANUB2G2_HUMANBioGRID, IntAct19690564 details
RN146_HUMANUBE2H_HUMANBioGRID, IntAct19549727 details
RN146_HUMANTRAF2_HUMANBioGRID, IntAct25416956 32296183 details
RN146_HUMANGCP4_HUMANBioGRID, IntAct25416956 details
RN146_HUMANKASH5_HUMANBioGRID, IntAct25416956 27107012 32296183 details
RN146_HUMANNDUF3_HUMANBioGRID, IntAct32296183 details
RN146_HUMANPARP1_HUMANBioGRID, IntAct, MINT21799911 21825151 26186194 28514442 details
RN146_HUMANTNKS1_HUMANBioGRID, DIP, MINT21799911 25327252 29604130 details
RN146_HUMANXRCC1_HUMANBioGRID, MINT21799911 21825151 details
RN146_HUMANRN146_HUMANBioGRID, MINT21799911 21825151 25327252 details
RN146_HUMANNDUV1_HUMANIntAct32814053 details
RN146_HUMANWFS1_HUMANIntAct32814053 details
RN146_HUMANXRCC6_HUMANBioGRID21825151 details
RN146_HUMANUB2D3_HUMANBioGRID21825151 25327252 details
RN146_HUMANUB2D1_HUMANBioGRID25327252 details
RN146_HUMANUB2D2_HUMANBioGRID25327252 details
RN146_HUMANPARP2_HUMANBioGRID, IntAct, MINT21799911 21825151 26186194 28514442 details
RN146_HUMANTNKS2_HUMANBioGRID, MINT21799911 27521426 details
RN146_HUMANHLTF_HUMANBioGRID, MINT21799911 21825151 26186194 details
RN146_HUMANHNRPU_HUMANBioGRID21825151 details
RN146_HUMANNUCL_HUMANBioGRID21825151 details
RN146_HUMANXRCC5_HUMANBioGRID21825151 details
RN146_HUMANBIP_HUMANBioGRID21825151 details
RN146_HUMANGRP75_HUMANBioGRID21825151 details
RN146_HUMANIPO5_HUMANBioGRID21825151 details
RN146_HUMANIPO7_HUMANBioGRID21825151 details
RN146_HUMANATPA_HUMANBioGRID21825151 details
RN146_HUMANTBB5_HUMANBioGRID21825151 details
RN146_HUMANH12_HUMANBioGRID21825151 details
RN146_HUMANGO45_HUMANBioGRID21478859 details
RN146_HUMANAPC_HUMANBioGRID23277359 details
RN146_HUMAN3BP2_HUMANBioGRID22153076 details
RN146_HUMANAXIN2_HUMANBioGRID21478859 27521426 details
RN146_HUMANPTEN_HUMANBioGRID25547115 details
RN146_HUMANXPO1_HUMANBioGRID26673895 30029878 details
RN146_HUMANKPCZ_HUMANBioGRID27521426 details
RN146_HUMANAJUBA_HUMANBioGRID27521426 details
RN146_HUMANL2GL1_HUMANBioGRID27521426 details
RN146_HUMANL2GL2_HUMANBioGRID27521426 details
RN146_HUMANSCRIB_HUMANBioGRID27521426 details
RN146_HUMANPAXI_HUMANBioGRID27521426 details
RN146_HUMANAFAD_HUMANBioGRID27521426 details
RN146_HUMANAMOL2_HUMANBioGRID27521426 details
RN146_HUMANAMOL1_HUMANBioGRID27521426 details
RN146_HUMANPAR6G_HUMANBioGRID27521426 details
RN146_HUMANPAR6A_HUMANBioGRID27521426 details
RN146_HUMANFRM4B_HUMANBioGRID27521426 details
RN146_HUMANAMOT_HUMANBioGRID27521426 details
RN146_HUMANBRD7_HUMANBioGRID30940648 details
RN146_HUMANSTK11_HUMANBioGRID31554794 details
RN146_HUMANTGFR1_HUMANHPRD15761153 details