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Entity Details
Primary name
UBP18_HUMAN
Entity type
UniProt
Source
Source Link
Details
Accession
Q9UMW8
EntryName
UBP18_HUMAN
FullName
Ubl carboxyl-terminal hydrolase 18
TaxID
9606
Evidence
evidence at protein level
Length
372
SequenceStatus
complete
DateCreated
2000-12-01
DateModified
2021-06-02
Ontological Relatives
Genes
USP18
GO terms
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GO
Name
GO:0004197
cysteine-type endopeptidase activity
GO:0004843
thiol-dependent deubiquitinase
GO:0005634
nucleus
GO:0005829
cytosol
GO:0006511
ubiquitin-dependent protein catabolic process
GO:0016579
protein deubiquitination
GO:0043231
intracellular membrane-bounded organelle
GO:0050727
regulation of inflammatory response
GO:0060338
regulation of type I interferon-mediated signaling pathway
GO:0060339
negative regulation of type I interferon-mediated signaling pathway
Subcellular Location
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Subcellular Location
Cytoplasm
Nucleus
Domains
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Domain
Name
Category
Type
IPR001394
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Domain
Domain
IPR018200
Ubiquitin specific protease, conserved site
Site
Conserved site
IPR028889
Ubiquitin specific protease domain
Domain
Domain
IPR038765
Papain-like cysteine peptidase superfamily
Family
Homologous superfamily
Diseases
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Drugs
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Interactions
38 interactions
Interactor
Partner
Sources
Publications
Link
UBP18_HUMAN
ISG15_HUMAN
BioGRID, DIP, HPRD, IntAct
16189514
25307056
25416956
30858391
31515488
32296183
details
UBP18_HUMAN
TM14A_HUMAN
BioGRID, MINT
21516116
details
UBP18_HUMAN
ZDH17_HUMAN
BioGRID, IntAct
24705354
details
UBP18_HUMAN
SKP2_HUMAN
BioGRID, DIP
15342634
25307056
30068654
30858391
details
UBP18_HUMAN
HD_HUMAN
IntAct
32814053
details
UBP18_HUMAN
TRI54_HUMAN
BioGRID
22626734
details
UBP18_HUMAN
STAT2_HUMAN
BioGRID
28165510
31836668
details
UBP18_HUMAN
TWST1_HUMAN
BioGRID
32368392
details
UBP18_HUMAN
NEMO_HUMAN
BioGRID, IntAct
14743216
26240016
details
UBP18_HUMAN
INAR2_HUMAN
BioGRID, HPRD, MINT
16710296
27716962
28165510
details
UBP18_HUMAN
UBP41_HUMAN
IntAct
19615732
28514442
details
UBP18_HUMAN
FKBP5_HUMAN
IntAct
25036637
details
UBP18_HUMAN
MLF1_HUMAN
IntAct
25036637
details
UBP18_HUMAN
NUDC3_HUMAN
IntAct
25036637
details
UBP18_HUMAN
SGTA_HUMAN
IntAct
25036637
details
UBP18_HUMAN
STIP1_HUMAN
IntAct
25036637
details
UBP18_HUMAN
FKBPL_HUMAN
IntAct
25036637
details
UBP18_HUMAN
CYBP_HUMAN
IntAct
25036637
details
UBP18_HUMAN
PTG3L_HUMAN
IntAct
25036637
details
UBP18_HUMAN
AASD1_HUMAN
IntAct
25036637
details
UBP18_HUMAN
TTC1_HUMAN
IntAct
25036637
details
UBP18_HUMAN
PCNA_HUMAN
BioGRID
24768535
details
UBP18_HUMAN
BECN1_HUMAN
BioGRID
25906440
details
UBP18_HUMAN
BAKOR_HUMAN
BioGRID
25906440
details
UBP18_HUMAN
PK3C3_HUMAN
BioGRID
25906440
details
UBP18_HUMAN
UVRAG_HUMAN
BioGRID
25906440
30686098
details
UBP18_HUMAN
TAB1_HUMAN
BioGRID
23825189
26240016
details
UBP18_HUMAN
M3K7_HUMAN
BioGRID
23825189
26240016
28718215
details
UBP18_HUMAN
IKKA_HUMAN
BioGRID
26240016
details
UBP18_HUMAN
IKKB_HUMAN
BioGRID
26240016
details
UBP18_HUMAN
CAR11_HUMAN
BioGRID
23825189
details
UBP18_HUMAN
TAB2_HUMAN
BioGRID
23825189
details
UBP18_HUMAN
STING_HUMAN
BioGRID
27801882
details
UBP18_HUMAN
B2CL1_HUMAN
BioGRID
28709980
details
UBP18_HUMAN
SAMH1_HUMAN
BioGRID
30068654
details
UBP18_HUMAN
IRS4_HUMAN
BioGRID
29285303
details
UBP18_HUMAN
CTNB1_HUMAN
BioGRID
30323974
details
UBP18_HUMAN
SNAI1_HUMAN
BioGRID
32742193
details
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