Entity Details

Primary name FIBB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02675
EntryNameFIBB_HUMAN
FullNameFibrinogen beta chain
TaxID9606
Evidenceevidence at protein level
Length491
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesFGB

GO terms

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GOName
GO:0002224 toll-like receptor signaling pathway
GO:0002250 adaptive immune response
GO:0002576 platelet degranulation
GO:0005102 signaling receptor binding
GO:0005198 structural molecule activity
GO:0005201 extracellular matrix structural constituent
GO:0005576 extracellular region
GO:0005577 fibrinogen complex
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007596 blood coagulation
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0030198 extracellular matrix organization
GO:0031091 platelet alpha granule
GO:0031093 platelet alpha granule lumen
GO:0031639 plasminogen activation
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0034622 cellular protein-containing complex assembly
GO:0042730 fibrinolysis
GO:0043152 induction of bacterial agglutination
GO:0044320 cellular response to leptin stimulus
GO:0045087 innate immune response
GO:0045202 synapse
GO:0045907 positive regulation of vasoconstriction
GO:0045921 positive regulation of exocytosis
GO:0050714 positive regulation of protein secretion
GO:0051087 chaperone binding
GO:0051258 protein polymerization
GO:0051592 response to calcium ion
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0071347 cellular response to interleukin-1
GO:0072378 blood coagulation, fibrin clot formation
GO:0072562 blood microparticle
GO:0090277 positive regulation of peptide hormone secretion
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903561 extracellular vesicle
GO:2000352 negative regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domainDomainDomain
IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domainDomainDomain
IPR020837 Fibrinogen, conserved siteSiteConserved site
IPR036056 Fibrinogen-like, C-terminalFamilyHomologous superfamily
IPR037580 Fibrinogen beta chainFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00364 SucralfateDrugbanksmall molecule
DB04919 AlfimepraseDrugbankbiotech
DB11300 ThrombinDrugbankbiotech
DB11311 ProthrombinDrugbankbiotech
DB11571 Human thrombinDrugbankbiotech
DB11572 Thrombin alfaDrugbankbiotech
DB13151 Anti-inhibitor coagulant complexDrugbankbiotech