Entity Details

Primary name ICAM1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05362
EntryNameICAM1_HUMAN
FullNameIntercellular adhesion molecule 1
TaxID9606
Evidenceevidence at protein level
Length532
SequenceStatuscomplete
DateCreated1988-11-01
DateModified2021-06-02

Ontological Relatives

GenesICAM1

GO terms

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GOName
GO:0001541 ovarian follicle development
GO:0001618 virus receptor activity
GO:0001772 immunological synapse
GO:0001910 regulation of leukocyte mediated cytotoxicity
GO:0001975 response to amphetamine
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0002438 acute inflammatory response to antigenic stimulus
GO:0002457 T cell antigen processing and presentation
GO:0002693 positive regulation of cellular extravasation
GO:0004888 transmembrane signaling receptor activity
GO:0005178 integrin binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 leukocyte cell-cell adhesion
GO:0007569 cell aging
GO:0007605 sensory perception of sound
GO:0008360 regulation of cell shape
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010212 response to ionizing radiation
GO:0010477 response to sulfur dioxide
GO:0016020 membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0022614 membrane to membrane docking
GO:0030198 extracellular matrix organization
GO:0030838 positive regulation of actin filament polymerization
GO:0031669 cellular response to nutrient levels
GO:0032868 response to insulin
GO:0033627 cell adhesion mediated by integrin
GO:0034698 response to gonadotropin
GO:0038023 signaling receptor activity
GO:0042493 response to drug
GO:0043200 response to amino acid
GO:0043547 positive regulation of GTPase activity
GO:0044406 adhesion of symbiont to host
GO:0045121 membrane raft
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045471 response to ethanol
GO:0045907 positive regulation of vasoconstriction
GO:0046688 response to copper ion
GO:0046813 receptor-mediated virion attachment to host cell
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776 regulation of immune response
GO:0050900 leukocyte migration
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051926 negative regulation of calcium ion transport
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0061028 establishment of endothelial barrier
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071222 cellular response to lipopolysaccharide
GO:0071312 cellular response to alkaloid
GO:0071333 cellular response to glucose stimulus
GO:0071347 cellular response to interleukin-1
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071456 cellular response to hypoxia
GO:0071549 cellular response to dexamethasone stimulus
GO:0072683 T cell extravasation
GO:0090557 establishment of endothelial intestinal barrier
GO:0097368 establishment of Sertoli cell barrier
GO:1900027 regulation of ruffle assembly
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1904646 cellular response to amyloid-beta
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell
GO:1990830 cellular response to leukemia inhibitory factor
GO:2000352 negative regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR003599 Immunoglobulin subtypeDomainDomain
IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminalDomainDomain
IPR003988 Intercellular adhesion moleculeDomainDomain
IPR013768 Intercellular adhesion molecule, N-terminalDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00108 NatalizumabDrugbankbiotech
DB08818 Hyaluronic acidDrugbanksmall molecule
DB12598 NafamostatDrugbanksmall molecule

Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
ICAM1_HUMANITAL_HUMANBioGRID, DIP, IntAct11279101 11786177 12526797 16595626 29997244 details
ICAM1_HUMAN3BHS7_HUMANBioGRID, IntAct21988832 details
ICAM1_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
ICAM1_HUMANKEAP1_HUMANBioGRID, IntAct32296183 details
ICAM1_HUMANUBQL2_HUMANBioGRID, IntAct32296183 details
ICAM1_HUMANKR108_HUMANBioGRID, IntAct32296183 details
ICAM1_HUMANPELO_HUMANIntAct32814053 details
ICAM1_HUMANCIB1_HUMANIntAct32814053 details
ICAM1_HUMANITB2_HUMANBioGRID, HPRD10352278 11279101 20187292 7642561 details
ICAM1_HUMANEZRI_HUMANBioGRID, HPRD9705328 details
ICAM1_HUMANITAM_HUMANBioGRID, HPRD11073102 12208882 9488691 details
ICAM1_HUMANUBC_HUMANMINT17174307 details
ICAM1_HUMANTF65_HUMANBioGRID, I2D, IntAct19351910 21706061 25879517 details
ICAM1_HUMANFIBG_HUMANBioGRID, HPRD, IntAct25241761 7822297 details
ICAM1_HUMANIL2RA_HUMANBioGRID, HPRD1976256 details
ICAM1_HUMANACTN1_HUMANBioGRID23463506 details
ICAM1_HUMANFLNA_HUMANBioGRID23463506 details
ICAM1_HUMANNUCL_HUMANBioGRID23463506 details
ICAM1_HUMANACTB_HUMANBioGRID23463506 31536960 details
ICAM1_HUMANMOES_HUMANBioGRID, HPRD12082081 23463506 details
ICAM1_HUMANSP1_HUMANBioGRID25879517 details
ICAM1_HUMANHIF1A_HUMANBioGRID25879517 details
ICAM1_HUMANEPAS1_HUMANBioGRID25879517 details
ICAM1_HUMANARNT_HUMANBioGRID25879517 details
ICAM1_HUMANMARH9_HUMANBioGRID30278450 details
ICAM1_HUMANICAM1_HUMANHPRD12526797 details
ICAM1_HUMANLEUK_HUMANHPRD1683685 details
ICAM1_HUMANIL2RG_HUMANHPRD1976256 details