Entity Details

Primary name BCL2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10415
EntryNameBCL2_HUMAN
FullNameApoptosis regulator Bcl-2
TaxID9606
Evidenceevidence at protein level
Length239
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesBCL2

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0001503 ossification
GO:0001541 ovarian follicle development
GO:0001656 metanephros development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001662 behavioral fear response
GO:0001782 B cell homeostasis
GO:0001836 release of cytochrome c from mitochondria
GO:0001952 regulation of cell-matrix adhesion
GO:0002020 protease binding
GO:0002320 lymphoid progenitor cell differentiation
GO:0002326 B cell lineage commitment
GO:0002931 response to ischemia
GO:0003014 renal system process
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006470 protein dephosphorylation
GO:0006582 melanin metabolic process
GO:0006808 regulation of nitrogen utilization
GO:0006915 apoptotic process
GO:0006959 humoral immune response
GO:0006974 cellular response to DNA damage stimulus
GO:0007015 actin filament organization
GO:0007409 axonogenesis
GO:0007565 female pregnancy
GO:0007569 cell aging
GO:0008284 positive regulation of cell population proliferation
GO:0008584 male gonad development
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009314 response to radiation
GO:0009636 response to toxic substance
GO:0009791 post-embryonic development
GO:0010039 response to iron ion
GO:0010224 response to UV-B
GO:0010332 response to gamma radiation
GO:0010468 regulation of gene expression
GO:0010507 negative regulation of autophagy
GO:0010523 negative regulation of calcium ion transport into cytosol
GO:0010559 regulation of glycoprotein biosynthetic process
GO:0014031 mesenchymal cell development
GO:0014042 positive regulation of neuron maturation
GO:0014911 positive regulation of smooth muscle cell migration
GO:0015267 channel activity
GO:0016020 membrane
GO:0016248 channel inhibitor activity
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0021747 cochlear nucleus development
GO:0022612 gland morphogenesis
GO:0022898 regulation of transmembrane transporter activity
GO:0030279 negative regulation of ossification
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0030318 melanocyte differentiation
GO:0030336 negative regulation of cell migration
GO:0030890 positive regulation of B cell proliferation
GO:0031069 hair follicle morphogenesis
GO:0031103 axon regeneration
GO:0031625 ubiquitin protein ligase binding
GO:0031647 regulation of protein stability
GO:0031965 nuclear membrane
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032835 glomerulus development
GO:0032848 negative regulation of cellular pH reduction
GO:0032991 protein-containing complex
GO:0033033 negative regulation of myeloid cell apoptotic process
GO:0033077 T cell differentiation in thymus
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033689 negative regulation of osteoblast proliferation
GO:0034097 response to cytokine
GO:0035094 response to nicotine
GO:0035265 organ growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042100 B cell proliferation
GO:0042149 cellular response to glucose starvation
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043029 T cell homeostasis
GO:0043066 negative regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043209 myelin sheath
GO:0043375 CD8-positive, alpha-beta T cell lineage commitment
GO:0043524 negative regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0043583 ear development
GO:0045069 regulation of viral genome replication
GO:0045636 positive regulation of melanocyte differentiation
GO:0046671 negative regulation of retinal cell programmed cell death
GO:0046902 regulation of mitochondrial membrane permeability
GO:0046930 pore complex
GO:0046982 protein heterodimerization activity
GO:0048041 focal adhesion assembly
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048546 digestive tract morphogenesis
GO:0048599 oocyte development
GO:0048743 positive regulation of skeletal muscle fiber development
GO:0048753 pigment granule organization
GO:0048873 homeostasis of number of cells within a tissue
GO:0050853 B cell receptor signaling pathway
GO:0051384 response to glucocorticoid
GO:0051402 neuron apoptotic process
GO:0051434 BH3 domain binding
GO:0051607 defense response to virus
GO:0051721 protein phosphatase 2A binding
GO:0051881 regulation of mitochondrial membrane potential
GO:0051902 negative regulation of mitochondrial depolarization
GO:0051924 regulation of calcium ion transport
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071456 cellular response to hypoxia
GO:0072593 reactive oxygen species metabolic process
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0098609 cell-cell adhesion
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000811 negative regulation of anoikis
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Mitochondrion outer membrane
Nucleus membrane

Domains

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DomainNameCategoryType
IPR002475 Bcl2-likeFamilyFamily
IPR003093 Apoptosis regulator, Bcl-2 protein, BH4DomainDomain
IPR004725 Apoptosis regulator, Bcl-2/ BclXFamilyFamily
IPR013278 Apoptosis regulator, Bcl-2FamilyFamily
IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved siteSiteConserved site
IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved siteSiteConserved site
IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved siteSiteConserved site
IPR020731 Apoptosis regulator, Bcl-2, BH4 motif, conserved siteSiteConserved site
IPR026298 Bcl-2 familyFamilyFamily
IPR036834 Bcl-2-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01050 IbuprofenDrugbanksmall molecule
DB01229 PaclitaxelDrugbanksmall molecule
DB01248 DocetaxelDrugbanksmall molecule
DB01367 RasagilineDrugbanksmall molecule
DB05297 Paclitaxel docosahexaenoic acidDrugbanksmall molecule
DB06307 ApoptoneDrugbanksmall molecule
DB06756 Glycine betaineDrugbanksmall molecule
DB08871 EribulinDrugbanksmall molecule
DB09213 DexibuprofenDrugbanksmall molecule
DB09401 IsosorbideDrugbanksmall molecule
DB11581 VenetoclaxDrugbanksmall molecule
DB12191 ObatoclaxDrugbanksmall molecule
DB12340 NavitoclaxDrugbanksmall molecule

Interactions

131 interactions

InteractorPartnerSourcesPublicationsLink
BCL2_HUMANBAP31_HUMANBioGRID, HPRD, IntAct31206022 9334338 details
BCL2_HUMANMK01_HUMANBioGRID, HPRD, MINT10567572 12039864 15225643 details
BCL2_HUMANPP2AA_HUMANBioGRID, HPRD, MINT15225643 9852076 details
BCL2_HUMANMK08_HUMANBioGRID, HPRD, MINT10567572 12039864 15225643 15733859 details
BCL2_HUMANFKBP8_HUMANBioGRID, HPRD, MINT12510191 15733859 15905180 15990872 17379601 17942410 details
BCL2_HUMANBID_HUMANBioGRID, DIP, HPRD, IntAct11583631 12624108 15520201 15694340 16697956 17289999 18835031 19074266 9463381 9727491 details
BCL2_HUMANBBC3B_HUMANBioGRID, HPRD, IntAct11463392 15694340 16697956 details
BCL2_HUMANBBC3_HUMANBioGRID, HPRD, IntAct11463392 15694340 16697956 17289999 26431330 details
BCL2_HUMANCANB1_HUMANMINT15757646 details
BCL2_HUMANBAX_HUMANBioGRID, DIP, HPRD, IntAct, MINT10620799 10716992 14980220 15231068 15899854 16642033 17097560 17289999 17525735 18981409 21199865 21458670 21671007 21778226 22262057 23479509 24141421 26004684 29749471 32064756 8358790 9111042 9388232 9463381 details
BCL2_HUMANBAK_HUMANBioGRID, HPRD, IntAct11206074 11728179 14980220 20836993 26004684 32064756 9463381 details
BCL2_HUMANBAD_HUMANBioGRID, HPRD, IntAct, MINT10611223 11483855 15694340 15849194 15990872 16697956 17446862 19168699 20603619 7834748 9305851 9388232 9463381 details
BCL2_HUMANBIK_HUMANBioGRID, HPRD, IntAct12853473 15694340 16697956 17289999 31387940 32296183 9463381 9488477 9525867 details
BCL2_HUMANBCL2_HUMANBioGRID, HPRD, IntAct15302859 18835031 9111042 9463381 details
BCL2_HUMANB2L11_HUMANBioGRID, HPRD, IntAct, MINT10198631 15694340 15899854 16697956 17074758 17097560 17289999 17692808 19805519 20836993 21199865 21671007 23845444 26004684 26186194 28514442 9430630 9463381 9731710 details
BCL2_HUMANBNIP2_HUMANBioGRID, HPRD, MINT10381623 12901880 7954800 details
BCL2_HUMANBNIP3_HUMANBioGRID, HPRD, MINT10381623 10625696 23504944 7954800 details
BCL2_HUMANBNI3L_HUMANBioGRID, HPRD, IntAct10467396 9973195 details
BCL2_HUMANPP1A_HUMANBioGRID, HPRD, IntAct11390485 17274640 details
BCL2_HUMANPP1G_HUMANBioGRID, IntAct17274640 details
BCL2_HUMANPP1B_HUMANBioGRID, IntAct17274640 details
BCL2_HUMANVRK2_HUMANIntAct16963744 details
BCL2_HUMANNLRP1_HUMANDIP, HPRD, IntAct17418785 19223583 details
BCL2_HUMANBECN1_HUMANBioGRID, DIP, HPRD, IntAct, matrixdb, MINT16179260 17446862 18641390 19050071 19180116 19347031 19959994 20010695 20577262 20622903 20711182 20889974 21139567 21358617 21543763 21971985 22082873 22241963 22498477 22622204 23168911 23316280 23479509 23504944 23541952 23564079 23822101 23954414 24034250 24141421 24472739 24599950 24879154 25891078 25984893 27304906 28128446 28431397 28682313 29079782 29849149 29955058 31410188 31696776 32097085 32820146 9765397 details
BCL2_HUMANCASP8_HUMANBioGRID, HPRD, IntAct11406564 16183855 details
BCL2_HUMANNR4A1_HUMANBioGRID, HPRD, IntAct14980220 16434970 18835031 details
BCL2_HUMANB2CL1_HUMANBioGRID, HPRD, IntAct11583631 12137781 14980220 18835031 26186194 28514442 details
BCL2_HUMANP53_HUMANBioGRID, HPRD, IntAct, MINT12667443 16443602 19521340 21597459 21624955 23316052 30683842 32064756 details
BCL2_HUMANCISD2_HUMANBioGRID, MINT20010695 details
BCL2_HUMANAMRA1_HUMANBioGRID, MINT21358617 details
BCL2_HUMANAPR_HUMANBioGRID, HPRD, IntAct10807576 15694340 21454712 details
BCL2_HUMANBMF_HUMANBioGRID, HPRD, IntAct11546872 16697956 17289999 details
BCL2_HUMANPPIF_HUMANUniProt19228691 details
BCL2_HUMANBCLF1_HUMANHPRD, IntAct10330179 23541952 details
BCL2_HUMANBRCA1_HUMANBioGRID, IntAct21444675 details
BCL2_HUMANLRRK2_HUMANIntAct25446991 details
BCL2_HUMANASPP2_HUMANBioGRID, DIP, HPRD18719108 8668206 details
BCL2_HUMANITPR1_HUMANBioGRID, DIP, HPRD15613488 19706527 details
BCL2_HUMANSODC_HUMANBioGRID, HPRD, IntAct15233914 32814053 details
BCL2_HUMANA4_HUMANIntAct32814053 details
BCL2_HUMANBNIPL_HUMANBioGRID, HPRD12901880 details
BCL2_HUMANSMN_HUMANBioGRID, HPRD9389483 details
BCL2_HUMANRTN4_HUMANBioGRID, HPRD11126360 17191123 details
BCL2_HUMANHRK_HUMANBioGRID, HPRD10075695 15694340 9130713 details
BCL2_HUMANCASP3_HUMANBioGRID, HPRD11752215 11948397 9395403 details
BCL2_HUMANCAN2_HUMANBioGRID12000759 details
BCL2_HUMANRRAS_HUMANBioGRID, HPRD8232588 details
BCL2_HUMANRAF1_HUMANBioGRID, HPRD12488548 15849194 8910675 8929532 details
BCL2_HUMANTOM20_HUMANBioGRID, HPRD9119086 details
BCL2_HUMANBLK_HUMANBioGRID, HPRD9525867 details
BCL2_HUMANRAD9A_HUMANBioGRID, HPRD10620799 18794804 details
BCL2_HUMANPSN1_HUMANBioGRID, HPRD10521466 15905180 details
BCL2_HUMANCDK1_HUMANBioGRID11326318 11774038 9668078 details
BCL2_HUMANAVEN_HUMANBioGRID10949025 details
BCL2_HUMANSEC20_HUMANBioGRID, HPRD10217402 details
BCL2_HUMANPARP1_HUMANBioGRID, HPRD11790116 details
BCL2_HUMANBAG1_HUMANBioGRID, HPRD9305631 details
BCL2_HUMANPRKN_HUMANBioGRID20889974 32929329 details
BCL2_HUMANMEX3D_HUMANBioGRID14769789 details
BCL2_HUMANHNRPD_HUMANBioGRID14769789 details
BCL2_HUMANBFAR_HUMANBioGRID, HPRD10716992 details
BCL2_HUMANPP2BC_HUMANBioGRID15757646 details
BCL2_HUMANSQSTM_HUMANBioGRID23564079 25311206 details
BCL2_HUMANPPID_HUMANBioGRID19228691 details
BCL2_HUMANPPARA_HUMANBioGRID26556865 details
BCL2_HUMANSEPT4_HUMANBioGRID29020630 details
BCL2_HUMANXIAP_HUMANBioGRID29020630 details
BCL2_HUMANB2L12_HUMANBioGRID29749471 details
BCL2_HUMANRN183_HUMANBioGRID29507230 details
BCL2_HUMANSPHK2_HUMANBioGRID28682313 details
BCL2_HUMANCPT1A_HUMANHPRD9070836 details
BCL2_HUMANNMT2_HUMANBioGRID, HPRD, MINT16530191 details
BCL2_HUMANSPNS1_HUMANBioGRID, HPRD, UniProt12815463 details
BCL2_HUMANSIVA_HUMANUniProt14739602 details
BCL2_HUMANMDM4_HUMANBioGRID, MINT19521340 24445145 details
BCL2_HUMANBECN2_HUMANIntAct23954414 details
BCL2_HUMANBOP_HUMANIntAct23055042 details
BCL2_HUMANNR4A3_HUMANMINT30455429 details
BCL2_HUMANSPB8_HUMANBioGRID15231068 details
BCL2_HUMANMYC_HUMANBioGRID, HPRD15210690 details
BCL2_HUMANTPIP1_HUMANBioGRID, HPRD12019168 details
BCL2_HUMANB2L10_HUMANBioGRID, HPRD11278245 details
BCL2_HUMANIRS1_HUMANBioGRID10679027 details
BCL2_HUMANIRS2_HUMANBioGRID10679027 details
BCL2_HUMANITM2B_HUMANBioGRID, HPRD12082633 details
BCL2_HUMANHS71A_HUMANBioGRID, HPRD10354271 details
BCL2_HUMANHS71B_HUMANBioGRID, HPRD10354271 details
BCL2_HUMANPIN1_HUMANBioGRID, HPRD11326318 11988841 details
BCL2_HUMAN2A5A_HUMANBioGRID, HPRD11929874 details
BCL2_HUMANBI1_HUMANBioGRID, HPRD9660918 details
BCL2_HUMANMOAP1_HUMANBioGRID, HPRD11060313 details
BCL2_HUMANPP2BA_HUMANBioGRID, HPRD19706527 7593193 9109491 details
BCL2_HUMANDYL1_HUMANBioGRID10198631 details
BCL2_HUMANBLID_HUMANBioGRID20400521 details
BCL2_HUMANHS90A_HUMANBioGRID20668552 21543763 details
BCL2_HUMANATG12_HUMANBioGRID22152474 details
BCL2_HUMANPML_HUMANBioGRID, HPRD15231068 details
BCL2_HUMANCRYAB_HUMANBioGRID20841355 details
BCL2_HUMANIKKB_HUMANBioGRID22262057 details
BCL2_HUMANIKKA_HUMANBioGRID22262057 details
BCL2_HUMANHIF1A_HUMANBioGRID20668552 23836782 details
BCL2_HUMANNEMO_HUMANBioGRID17363905 details
BCL2_HUMANBAG3_HUMANBioGRID, HPRD11513873 23341456 details
BCL2_HUMANRASK_HUMANBioGRID, HPRD10490827 19433448 details
BCL2_HUMANAT2A3_HUMANBioGRID9788433 details
BCL2_HUMANVDAC1_HUMANBioGRID19706527 details
BCL2_HUMANGIMA5_HUMANBioGRID16509771 details
BCL2_HUMANMETK2_HUMANBioGRID26416353 details
BCL2_HUMANUBC9_HUMANBioGRID26416353 details
BCL2_HUMANBARD1_HUMANBioGRID26022179 details
BCL2_HUMANRTN3_HUMANBioGRID17191123 details
BCL2_HUMANKEAP1_HUMANBioGRID30126895 details
BCL2_HUMANPSN2_HUMANBioGRID15905180 details
BCL2_HUMANCDK2_HUMANBioGRID, HPRD15619620 details
BCL2_HUMANITPR3_HUMANBioGRID15613488 details
BCL2_HUMANLPPRC_HUMANBioGRID23822101 details
BCL2_HUMANLFG2_HUMANBioGRID26582200 details
BCL2_HUMANAT2A2_HUMANHPRD9788433 details
BCL2_HUMANKAPCA_HUMANHPRD11158204 7929424 9115213 details
BCL2_HUMANMK03_HUMANHPRD10677502 details
BCL2_HUMANMK14_HUMANHPRD11495898 details
BCL2_HUMANCYC_HUMANHPRD10622714 details
BCL2_HUMANPAXI_HUMANHPRD10417825 details
BCL2_HUMANRASN_HUMANHPRD10490827 details
BCL2_HUMANKPCA_HUMANHPRD9738012 details
BCL2_HUMANRASH_HUMANHPRD10490827 details
BCL2_HUMANSF01_HUMANHPRD8668206 details
BCL2_HUMANPMYT1_HUMANHPRD11326318 details
BCL2_HUMANMK11_HUMANHPRD11495898 details
BCL2_HUMANBAG4_HUMANHPRD11527400 details
BCL2_HUMANB2L14_HUMANHPRD11054413 details