Entity Details

Primary name CCL5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13501
EntryNameCCL5_HUMAN
FullNameC-C motif chemokine 5
TaxID9606
Evidenceevidence at protein level
Length91
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesCCL5

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0002407 dendritic cell chemotaxis
GO:0002548 monocyte chemotaxis
GO:0002676 regulation of chronic inflammatory response
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004672 protein kinase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006887 exocytosis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007159 leukocyte cell-cell adhesion
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008009 chemokine activity
GO:0009615 response to virus
GO:0009636 response to toxic substance
GO:0010536 positive regulation of activation of Janus kinase activity
GO:0010759 positive regulation of macrophage chemotaxis
GO:0010820 positive regulation of T cell chemotaxis
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016004 phospholipase activator activity
GO:0019221 cytokine-mediated signaling pathway
GO:0030298 receptor signaling protein tyrosine kinase activator activity
GO:0030335 positive regulation of cell migration
GO:0030593 neutrophil chemotaxis
GO:0031328 positive regulation of cellular biosynthetic process
GO:0031584 activation of phospholipase D activity
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0031726 CCR1 chemokine receptor binding
GO:0031729 CCR4 chemokine receptor binding
GO:0031730 CCR5 chemokine receptor binding
GO:0033634 positive regulation of cell-cell adhesion mediated by integrin
GO:0034112 positive regulation of homotypic cell-cell adhesion
GO:0042056 chemoattractant activity
GO:0042102 positive regulation of T cell proliferation
GO:0042119 neutrophil activation
GO:0042327 positive regulation of phosphorylation
GO:0042379 chemokine receptor binding
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043491 protein kinase B signaling
GO:0043547 positive regulation of GTPase activity
GO:0043621 protein self-association
GO:0043922 negative regulation by host of viral transcription
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045070 positive regulation of viral genome replication
GO:0045071 negative regulation of viral genome replication
GO:0045089 positive regulation of innate immune response
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway
GO:0045785 positive regulation of cell adhesion
GO:0045948 positive regulation of translational initiation
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0046817 chemokine receptor antagonist activity
GO:0048020 CCR chemokine receptor binding
GO:0048245 eosinophil chemotaxis
GO:0048246 macrophage chemotaxis
GO:0048247 lymphocyte chemotaxis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050796 regulation of insulin secretion
GO:0050863 regulation of T cell activation
GO:0051928 positive regulation of calcium ion transport
GO:0070098 chemokine-mediated signaling pathway
GO:0070233 negative regulation of T cell apoptotic process
GO:0070234 positive regulation of T cell apoptotic process
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071407 cellular response to organic cyclic compound
GO:0090026 positive regulation of monocyte chemotaxis
GO:0098586 cellular response to virus
GO:1901214 regulation of neuron death
GO:2000406 positive regulation of T cell migration
GO:2000503 positive regulation of natural killer cell chemotaxis

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000827 CC chemokine, conserved siteSiteConserved site
IPR001811 Chemokine interleukin-8-like domainDomainDomain
IPR036048 Chemokine interleukin-8-like superfamilyFamilyHomologous superfamily
IPR039809 Chemokine beta/gamma/deltaFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB02322 Heparin Disaccharide I-SDrugbanksmall molecule
DB02353 Heparin Disaccharide Iii-SDrugbanksmall molecule

Interactions

58 interactions

InteractorPartnerSourcesPublicationsLink
CCL5_HUMANDPP4_HUMANHPRD, MINT11390394 21314817 9516414 details
CCL5_HUMANTF65_HUMANBioGRID, IntAct21988832 details
CCL5_HUMANGTR5_HUMANBioGRID, IntAct21988832 details
CCL5_HUMANRAGP1_HUMANBioGRID, IntAct21988832 details
CCL5_HUMANTRIP6_HUMANBioGRID, IntAct21988832 details
CCL5_HUMANEDC4_HUMANBioGRID, IntAct21988832 details
CCL5_HUMANCCR5_HUMANbhf-ucl, BioGRID, HPRD, MINT10477718 11116158 11449371 14637022 23480650 28381538 8663314 9289016 details
CCL5_HUMANCCL5_HUMANbhf-ucl, DIP, HPRD, MINT15530372 21827949 23480650 28381538 7542919 8576227 9889151 details
CCL5_HUMANAPC_HUMANBioGRID, MINT25640309 details
CCL5_HUMANBAG4_HUMANBioGRID, MINT25640309 details
CCL5_HUMANBCAR3_HUMANBioGRID, MINT25640309 details
CCL5_HUMANCADH1_HUMANMINT25640309 details
CCL5_HUMANCHK2_HUMANBioGRID, MINT25640309 details
CCL5_HUMANRASK_HUMANBioGRID, MINT25640309 details
CCL5_HUMANPALB2_HUMANBioGRID, MINT25640309 details
CCL5_HUMANPHB_HUMANBioGRID, MINT25640309 details
CCL5_HUMANPTN1_HUMANBioGRID, MINT25640309 details
CCL5_HUMANTGFB1_HUMANBioGRID, MINT25640309 details
CCL5_HUMANWT1_HUMANBioGRID, MINT25640309 details
CCL5_HUMANTSG6_HUMANIntAct24501198 details
CCL5_HUMANCCL17_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANPLF4_HUMANbhf-ucl, BioGRID, HPRD15459010 28381538 details
CCL5_HUMANSDF1_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCXL11_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCCL2_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCXCL9_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCXCL7_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCXCL6_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCXCL2_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANXCL2_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANXCL1_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCCL28_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCCL26_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCCL25_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCCL24_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCCL21_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCCL20_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCCL16_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCCL13_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCCL11_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCXL10_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCXL17_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCXL14_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCCL27_HUMANbhf-ucl, BioGRID28381538 details
CCL5_HUMANCCR1_HUMANbhf-ucl, BioGRID, HPRD11116158 11449371 12270118 14637022 28381538 7545673 9289016 details
CCL5_HUMANIL8_HUMANBioGRID11509627 details
CCL5_HUMANACKR2_HUMANBioGRID, HPRD9405404 details
CCL5_HUMANCCR3_HUMANBioGRID, HPRD11449371 8642344 9289016 details
CCL5_HUMANCCR4_HUMANBioGRID, HPRD12270118 8573157 details
CCL5_HUMANCSPG2_HUMANBioGRID, HPRD11083865 details
CCL5_HUMANFZR1_HUMANBioGRID25640309 details
CCL5_HUMANSDC1_HUMANBioGRID, HPRD14637022 details
CCL5_HUMANSDC4_HUMANBioGRID, HPRD14637022 details
CCL5_HUMANPIGR_HUMANHPRD11509627 details
CCL5_HUMANIBP7_HUMANHPRD12847218 details
CCL5_HUMANACKR4_HUMANHPRD9469451 details
CCL5_HUMANGRB2_HUMANHPRD9009162 details
CCL5_HUMANACKR1_HUMANHPRD12081195 17416748 details