Entity Details

Primary name ANPRB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20594
EntryNameANPRB_HUMAN
FullNameAtrial natriuretic peptide receptor 2
TaxID9606
Evidenceevidence at protein level
Length1047
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesNPR2

GO terms

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GOName
GO:0001503 ossification
GO:0001653 peptide receptor activity
GO:0004383 guanylate cyclase activity
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006182 cGMP biosynthetic process
GO:0007165 signal transduction
GO:0007168 receptor guanylyl cyclase signaling pathway
GO:0008217 regulation of blood pressure
GO:0010753 positive regulation of cGMP-mediated signaling
GO:0016941 natriuretic peptide receptor activity
GO:0017046 peptide hormone binding
GO:0019934 cGMP-mediated signaling
GO:0022414 reproductive process
GO:0042562 hormone binding
GO:0042802 identical protein binding
GO:0051447 negative regulation of meiotic cell cycle
GO:0060348 bone development
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:1900194 negative regulation of oocyte maturation
GO:1903779 regulation of cardiac conduction

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclaseDomainDomain
IPR001170 Adenylyl cyclase class-4/guanylyl cyclaseFamilyFamily
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001828 Receptor, ligand binding regionDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved siteSiteConserved site
IPR028082 Periplasmic binding protein-like IFamilyHomologous superfamily
IPR029787 Nucleotide cyclaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01613 Erythrityl tetranitrateDrugbanksmall molecule
DB04899 NesiritideDrugbankbiotech