Entity Details

Primary name MPRD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20645
EntryNameMPRD_HUMAN
FullNameCation-dependent mannose-6-phosphate receptor
TaxID9606
Evidenceevidence at protein level
Length277
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesM6PR

GO terms

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GOName
GO:0004888 transmembrane signaling receptor activity
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005770 late endosome
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006622 protein targeting to lysosome
GO:0006898 receptor-mediated endocytosis
GO:0007041 lysosomal transport
GO:0008333 endosome to lysosome transport
GO:0016020 membrane
GO:0019904 protein domain specific binding
GO:0030133 transport vesicle
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0032588 trans-Golgi network membrane
GO:0033299 secretion of lysosomal enzymes
GO:0048471 perinuclear region of cytoplasm
GO:0061024 membrane organization
GO:1905394 retromer complex binding

Subcellular Location

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Subcellular Location
Lysosome membrane

Domains

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DomainNameCategoryType
IPR000296 Cation-dependent mannose-6-phosphate receptorFamilyFamily
IPR009011 Mannose-6-phosphate receptor binding domain superfamilyFamilyHomologous superfamily
IPR028927 Mannose-6-phosphate receptorFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00103 Agalsidase betaSwissprotbiotech
DB01272 Alglucosidase alfaDrugbankbiotech
DB02755 1-3 Sugar Ring of Pentamannosyl 6-PhosphateDrugbanksmall molecule
DB02900 alpha-D-mannose 6-phosphateDrugbanksmall molecule
DB15874 Agalsidase alfaSwissprotbiotech