Entity Details

Primary name MK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21741
EntryNameMK_HUMAN
FullNameMidkine
TaxID9606
Evidenceevidence at protein level
Length143
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesMDK

GO terms

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GOName
GO:0002232 leukocyte chemotaxis involved in inflammatory response
GO:0002286 T cell activation involved in immune response
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0005576 extracellular region
GO:0007010 cytoskeleton organization
GO:0007162 negative regulation of cell adhesion
GO:0007165 signal transduction
GO:0007219 Notch signaling pathway
GO:0007399 nervous system development
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0009611 response to wounding
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010759 positive regulation of macrophage chemotaxis
GO:0010838 positive regulation of keratinocyte proliferation
GO:0010976 positive regulation of neuron projection development
GO:0010996 response to auditory stimulus
GO:0030154 cell differentiation
GO:0030279 negative regulation of ossification
GO:0030325 adrenal gland development
GO:0030335 positive regulation of cell migration
GO:0032330 regulation of chondrocyte differentiation
GO:0032735 positive regulation of interleukin-12 production
GO:0035374 chondroitin sulfate binding
GO:0042246 tissue regeneration
GO:0043524 negative regulation of neuron apoptotic process
GO:0044849 estrous cycle
GO:0045582 positive regulation of T cell differentiation
GO:0045590 negative regulation of regulatory T cell differentiation
GO:0045785 positive regulation of cell adhesion
GO:0046850 regulation of bone remodeling
GO:0048477 oogenesis
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0050729 positive regulation of inflammatory response
GO:0051781 positive regulation of cell division
GO:0061036 positive regulation of cartilage development
GO:0071673 positive regulation of smooth muscle cell chemotaxis
GO:0090023 positive regulation of neutrophil chemotaxis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0106015 negative regulation of inflammatory response to wounding
GO:0106016 positive regulation of inflammatory response to wounding
GO:0106091 glial cell projection elongation
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:1904036 negative regulation of epithelial cell apoptotic process
GO:1904399 heparan sulfate binding
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell
GO:1905555 positive regulation of blood vessel branching
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:1905653 positive regulation of artery morphogenesis
GO:2000179 positive regulation of neural precursor cell proliferation
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2000347 positive regulation of hepatocyte proliferation
GO:2000391 positive regulation of neutrophil extravasation
GO:2001224 positive regulation of neuron migration

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000762 Midkine heparin-binding growth factorFamilyFamily
IPR020089 Pleiotrophin/Midkine, N-terminal domainDomainDomain
IPR020090 Pleiotrophin/Midkine, C-terminal domainDomainDomain
IPR020091 Pleiotrophin/Midkine disulphide-rich domain superfamilyFamilyHomologous superfamily
IPR020092 Pleiotrophin/Midkine heparin-binding growth factor, conserved siteSiteConserved site
IPR037122 Pleiotrophin/Midkine, N-terminal domain superfamilyFamilyHomologous superfamily
IPR038130 Pleiotrophin/Midkine, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
MK_HUMANRL18A_HUMANBioGRID, HPRD, IntAct16169070 details
MK_HUMANUBQL4_HUMANBioGRID, HPRD, IntAct16713569 details
MK_HUMANMK06_HUMANBioGRID, MINT21900206 details
MK_HUMANSRPK2_HUMANBioGRID, IntAct23602568 details
MK_HUMANUBQL1_HUMANBioGRID, IntAct32296183 details
MK_HUMANJOS2_HUMANBioGRID, IntAct32296183 details
MK_HUMANTCEA2_HUMANBioGRID, IntAct32296183 details
MK_HUMANRBFA_HUMANBioGRID, IntAct32296183 details
MK_HUMANTMED8_HUMANBioGRID, IntAct32296183 details
MK_HUMANNFU1_HUMANBioGRID, IntAct32296183 details
MK_HUMANUBQL2_HUMANBioGRID, IntAct32296183 details
MK_HUMANMID49_HUMANBioGRID, IntAct32296183 details
MK_HUMANAP1M1_HUMANBioGRID, IntAct32296183 details
MK_HUMANHCK_HUMANBioGRID, IntAct32296183 details
MK_HUMANNUCL_HUMANBioGRID, HPRD12147681 details
MK_HUMANPTPRZ_HUMANBioGRID, HPRD10212223 details
MK_HUMANFBX7_HUMANBioGRID27503909 details
MK_HUMANLRP6_HUMANBioGRID12573468 details
MK_HUMANLRP8_HUMANBioGRID12573468 details
MK_HUMANALK_HUMANBioGRID, HPRD12122009 details
MK_HUMANPBX3_HUMANBioGRID32296183 details
MK_HUMANCDC42_HUMANBioGRID31478661 details
MK_HUMANTSN1_HUMANHPRD18851943 details
MK_HUMANNCAM1_HUMANBioGRID10772929 details
MK_HUMANNID1_HUMANBioGRID10772929 details
MK_HUMANNID2_HUMANBioGRID10772929 details
MK_HUMANACTG_HUMANBioGRID10772929 details
MK_HUMANTBA1A_HUMANBioGRID10772929 details
MK_HUMANTBB2B_HUMANBioGRID10772929 details
MK_HUMANLRP1_HUMANBioGRID, HPRD10772929 details
MK_HUMANJAK1_HUMANHPRD9452495 details
MK_HUMANJAK2_HUMANHPRD9452495 details
MK_HUMANMK_HUMANHPRD8694802 details
MK_HUMANSDC1_HUMANHPRD9089390 details
MK_HUMANSDC3_HUMANHPRD9089390 details
MK_HUMANTGM1_HUMANHPRD9384573 details
MK_HUMANLRP2_HUMANHPRD10772929 details
MK_HUMANSTAT1_HUMANHPRD9452495 details
MK_HUMANSDC4_HUMANHPRD8621465 details