Entity Details

Primary name GATA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23769
EntryNameGATA2_HUMAN
FullNameEndothelial transcription factor GATA-2
TaxID9606
Evidenceevidence at protein level
Length480
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesGATA2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001655 urogenital system development
GO:0001709 cell fate determination
GO:0001764 neuron migration
GO:0001892 embryonic placenta development
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006909 phagocytosis
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007596 blood coagulation
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010725 regulation of primitive erythrocyte differentiation
GO:0021514 ventral spinal cord interneuron differentiation
GO:0021533 cell differentiation in hindbrain
GO:0021902 commitment of neuronal cell to specific neuron type in forebrain
GO:0021954 central nervous system neuron development
GO:0021983 pituitary gland development
GO:0033993 response to lipid
GO:0035019 somatic stem cell population maintenance
GO:0035065 regulation of histone acetylation
GO:0035854 eosinophil fate commitment
GO:0042472 inner ear morphogenesis
GO:0043306 positive regulation of mast cell degranulation
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045165 cell fate commitment
GO:0045599 negative regulation of fat cell differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045650 negative regulation of macrophage differentiation
GO:0045654 positive regulation of megakaryocyte differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048469 cell maturation
GO:0048873 homeostasis of number of cells within a tissue
GO:0050766 positive regulation of phagocytosis
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0060216 definitive hemopoiesis
GO:0060872 semicircular canal development
GO:0061042 vascular wound healing
GO:0070345 negative regulation of fat cell proliferation
GO:0070742 C2H2 zinc finger domain binding
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090102 cochlea development
GO:0097154 GABAergic neuron differentiation
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000178 negative regulation of neural precursor cell proliferation
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2000977 regulation of forebrain neuron differentiation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000679 Zinc finger, GATA-typeDomainDomain
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR016374 Transcription factor, GATA-2/3FamilyFamily
IPR029522 Transcription factor GATA-2FamilyFamily
IPR039355 Transcription factor GATAFamilyFamily

Diseases

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Interactions

65 interactions

InteractorPartnerSourcesPublicationsLink
GATA2_HUMANTAL1_HUMANBioGRID, IntAct7568177 details
GATA2_HUMANSMAD4_HUMANBioGRID, IntAct20211142 21988832 details
GATA2_HUMANPSA3_HUMANBioGRID, IntAct25416956 31515488 details
GATA2_HUMANTRI23_HUMANBioGRID, IntAct25416956 31515488 details
GATA2_HUMANKR109_HUMANBioGRID, IntAct25416956 details
GATA2_HUMANPR20C_HUMANBioGRID, IntAct25416956 details
GATA2_HUMANGOGA2_HUMANBioGRID, IntAct25416956 31515488 details
GATA2_HUMANTRAF1_HUMANBioGRID, IntAct25416956 details
GATA2_HUMANFHL3_HUMANBioGRID, IntAct25416956 31515488 details
GATA2_HUMANK1C40_HUMANBioGRID, IntAct25416956 details
GATA2_HUMANATL4_HUMANBioGRID, IntAct25416956 details
GATA2_HUMANNT2NA_HUMANBioGRID, IntAct25416956 31515488 details
GATA2_HUMANMDFI_HUMANBioGRID, IntAct25416956 31515488 details
GATA2_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
GATA2_HUMANRBPMS_HUMANBioGRID, IntAct32296183 details
GATA2_HUMANKRA71_HUMANBioGRID, IntAct32296183 details
GATA2_HUMANKR133_HUMANBioGRID, IntAct32296183 details
GATA2_HUMANMSX2_HUMANBioGRID, IntAct32296183 details
GATA2_HUMANKRA31_HUMANBioGRID, IntAct32296183 details
GATA2_HUMANKRA81_HUMANBioGRID, IntAct32296183 details
GATA2_HUMANKR111_HUMANBioGRID, IntAct32296183 details
GATA2_HUMANKR212_HUMANBioGRID, IntAct32296183 details
GATA2_HUMANHDAC1_HUMANDIP18250304 details
GATA2_HUMANCBP_HUMANDIP18250304 details
GATA2_HUMANSPI1_HUMANBioGRID, DIP, HPRD10364157 10411939 18250304 details
GATA2_HUMANCLAT_HUMANIntAct32814053 details
GATA2_HUMANFGFR3_HUMANIntAct32814053 details
GATA2_HUMANGRN_HUMANIntAct32814053 details
GATA2_HUMANWFS1_HUMANIntAct32814053 details
GATA2_HUMANRNF11_HUMANIntAct32814053 details
GATA2_HUMANZBT32_HUMANBioGRID, HPRD, IntAct11964310 20211142 details
GATA2_HUMANOBF1_HUMANBioGRID, IntAct20211142 details
GATA2_HUMANPML_HUMANBioGRID, HPRD10938104 details
GATA2_HUMANHDAC3_HUMANBioGRID, HPRD11567998 details
GATA2_HUMANPIT1_HUMANBioGRID, HPRD10367888 16396960 details
GATA2_HUMANZBT16_HUMANBioGRID, HPRD11964310 details
GATA2_HUMANRBTN2_HUMANBioGRID7568177 details
GATA2_HUMANJUN_HUMANBioGRID, HPRD11278891 details
GATA2_HUMANMED1_HUMANBioGRID16396960 details
GATA2_HUMANEP300_HUMANBioGRID15001660 details
GATA2_HUMANKAT2A_HUMANBioGRID15001660 details
GATA2_HUMANAKT1_HUMANBioGRID, HPRD15837948 details
GATA2_HUMANPR20E_HUMANBioGRID25416956 details
GATA2_HUMANPR20D_HUMANBioGRID25416956 details
GATA2_HUMANPR20B_HUMANBioGRID25416956 details
GATA2_HUMANPR20A_HUMANBioGRID25416956 details
GATA2_HUMANKR103_HUMANBioGRID25416956 details
GATA2_HUMANNT2NC_HUMANBioGRID25416956 details
GATA2_HUMANFBXW7_HUMANBioGRID25670854 details
GATA2_HUMANCDK1_HUMANBioGRID25670854 details
GATA2_HUMANRARA_HUMANHPRD15254248 details
GATA2_HUMANFOG1_HUMANBioGRID, HPRD, IntAct12483298 28514442 details
GATA2_HUMANCOT2_HUMANDIP18250317 details
GATA2_HUMANHDAC5_HUMANBioGRID, HPRD11567998 details
GATA2_HUMANSKP1_HUMANBioGRID25670854 details
GATA2_HUMANCUL1_HUMANBioGRID25670854 details
GATA2_HUMANRBX1_HUMANBioGRID25670854 details
GATA2_HUMANCCNA2_HUMANBioGRID17255359 details
GATA2_HUMANCDK2_HUMANBioGRID17255359 details
GATA2_HUMANCDK4_HUMANBioGRID17255359 details
GATA2_HUMANCEBPA_HUMANHPRD1563207 details
GATA2_HUMANSTAT3_HUMANHPRD15673499 details
GATA2_HUMANMK01_HUMANHPRD7876160 details
GATA2_HUMANHHEX_HUMANHPRD15016828 details
GATA2_HUMANRXRA_HUMANHPRD15254248 details