Entity Details

Primary name ITA3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP26006
EntryNameITA3_HUMAN
FullNameIntegrin alpha-3
TaxID9606
Evidenceevidence at protein level
Length1051
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesITGA3

GO terms

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GOName
GO:0001764 neuron migration
GO:0001968 fibronectin binding
GO:0002020 protease binding
GO:0005178 integrin binding
GO:0005518 collagen binding
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007507 heart development
GO:0007613 memory
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0010811 positive regulation of cell-substrate adhesion
GO:0010976 positive regulation of neuron projection development
GO:0016323 basolateral plasma membrane
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0019904 protein domain specific binding
GO:0030111 regulation of Wnt signaling pathway
GO:0030198 extracellular matrix organization
GO:0030324 lung development
GO:0030510 regulation of BMP signaling pathway
GO:0031345 negative regulation of cell projection organization
GO:0031527 filopodium membrane
GO:0034667 integrin alpha3-beta1 complex
GO:0034698 response to gonadotropin
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035640 exploration behavior
GO:0042493 response to drug
GO:0043235 receptor complex
GO:0043236 laminin binding
GO:0043588 skin development
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0048333 mesodermal cell differentiation
GO:0048471 perinuclear region of cytoplasm
GO:0050900 leukocyte migration
GO:0060076 excitatory synapse
GO:0060135 maternal process involved in female pregnancy
GO:0070062 extracellular exosome
GO:0071944 cell periphery
GO:0072006 nephron development
GO:0097060 synaptic membrane
GO:0097062 dendritic spine maintenance
GO:0097205 renal filtration
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1990812 growth cone filopodium

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR000413 Integrin alpha chainFamilyFamily
IPR013517 FG-GAP repeatRepeatRepeat
IPR013519 Integrin alpha beta-propellorRepeatRepeat
IPR013649 Integrin alpha-2DomainDomain
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved siteSiteConserved site
IPR028994 Integrin alpha, N-terminalFamilyHomologous superfamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614748 OMIMInterstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital (ILNEB)A multiorgan disorder characterized by congenital nephrotic syndrome, interstitial lung disease, and epidermolysis bullosa. The respiratory and renal features predominate, and lung involvement accounts for the lethal course of the disease. The disease is caused by variants affecting the gene represented in this entry.