Entity Details

Primary name HMGB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP26583
EntryNameHMGB2_HUMAN
FullNameHigh mobility group protein B2
TaxID9606
Evidenceevidence at protein level
Length209
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesHMGB2

GO terms

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GOName
GO:0000400 four-way junction DNA binding
GO:0000785 chromatin
GO:0000793 condensed chromosome
GO:0000976 transcription cis-regulatory region binding
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002437 inflammatory response to antigenic stimulus
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0006265 DNA topological change
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006309 apoptotic DNA fragmentation
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007289 spermatid nucleus differentiation
GO:0008134 transcription factor binding
GO:0008301 DNA binding, bending
GO:0008584 male gonad development
GO:0010629 negative regulation of gene expression
GO:0019904 protein domain specific binding
GO:0032075 positive regulation of nuclease activity
GO:0032392 DNA geometric change
GO:0032496 response to lipopolysaccharide
GO:0032728 positive regulation of interferon-beta production
GO:0032991 protein-containing complex
GO:0033151 V(D)J recombination
GO:0042056 chemoattractant activity
GO:0043388 positive regulation of DNA binding
GO:0044378 non-sequence-specific DNA binding, bending
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045654 positive regulation of megakaryocyte differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048471 perinuclear region of cytoplasm
GO:0048545 response to steroid hormone
GO:0050767 regulation of neurogenesis
GO:0050786 RAGE receptor binding
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0060326 cell chemotaxis
GO:0071222 cellular response to lipopolysaccharide
GO:0072091 regulation of stem cell proliferation
GO:0097100 supercoiled DNA binding
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR009071 High mobility group box domainDomainDomain
IPR017967 HMG box A DNA-binding domain, conserved siteSiteConserved site
IPR036910 High mobility group box domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
HMGB2_HUMANHMGA1_HUMANBioGRID, IntAct18850631 details
HMGB2_HUMANFLNA_HUMANBioGRID, IntAct, UniProt26496610 31694235 details
HMGB2_HUMANTSNAX_HUMANBioGRID, IntAct32296183 details
HMGB2_HUMANPKNX1_HUMANBioGRID, IntAct25416956 31515488 32296183 details
HMGB2_HUMANCATIN_HUMANBioGRID, UniProt29721183 details
HMGB2_HUMANEIF1_HUMANBioGRID, UniProt29721183 details
HMGB2_HUMANH33_HUMANBioGRID, UniProt29721183 details
HMGB2_HUMANMIEN1_HUMANBioGRID, UniProt29721183 31694235 32867128 details
HMGB2_HUMANNP1L1_HUMANBioGRID, UniProt29721183 details
HMGB2_HUMANZN428_HUMANBioGRID, UniProt29721183 31694235 32867128 details
HMGB2_HUMANZN622_HUMANBioGRID, UniProt29721183 details
HMGB2_HUMANZN668_HUMANBioGRID, UniProt29721183 32867128 details
HMGB2_HUMANCOPD_HUMANBioGRID, UniProt29721183 details
HMGB2_HUMANHACD3_HUMANBioGRID, UniProt29721183 details
HMGB2_HUMANVIGLN_HUMANBioGRID, UniProt29721183 details
HMGB2_HUMANLZTS1_HUMANBioGRID, UniProt29721183 details
HMGB2_HUMANNCBP3_HUMANBioGRID, UniProt29721183 details
HMGB2_HUMANNEXN_HUMANBioGRID, UniProt29721183 details
HMGB2_HUMANSAM50_HUMANBioGRID, UniProt29721183 details
HMGB2_HUMANC1QBP_HUMANBioGRID, UniProt29721183 31694235 details
HMGB2_HUMANSNAPN_HUMANUniProt31694235 details
HMGB2_HUMANU2AF1_HUMANUniProt31694235 32867128 details
HMGB2_HUMANUHRF2_HUMANUniProt31694235 details
HMGB2_HUMANCOMD1_HUMANUniProt31694235 32867128 details
HMGB2_HUMANMYL6_HUMANUniProt31694235 details
HMGB2_HUMANNOP53_HUMANUniProt31694235 32867128 details
HMGB2_HUMANRS28_HUMANUniProt31694235 details
HMGB2_HUMANBCCIP_HUMANUniProt32867128 details
HMGB2_HUMANROCK1_HUMANUniProt32867128 details
HMGB2_HUMANPCBP1_HUMANUniProt32867128 details
HMGB2_HUMANTBC25_HUMANUniProt32867128 details
HMGB2_HUMANZFR_HUMANUniProt32867128 details
HMGB2_HUMANPO2F2_HUMANBioGRID, HPRD7720710 details
HMGB2_HUMANRAG1_HUMANBioGRID, HPRD10490593 details
HMGB2_HUMANPRGR_HUMANBioGRID, HPRD9671457 details
HMGB2_HUMANGCR_HUMANBioGRID9671457 details
HMGB2_HUMANANDR_HUMANBioGRID9671457 details
HMGB2_HUMANSET_HUMANBioGRID, HPRD11909973 details
HMGB2_HUMANGRAA_HUMANBioGRID, HPRD11909973 17008916 details
HMGB2_HUMANCBP_HUMANBioGRID15005629 details
HMGB2_HUMANCAF1A_HUMANBioGRID21209461 details
HMGB2_HUMANA4_HUMANBioGRID21832049 details
HMGB2_HUMANGRAK_HUMANBioGRID17008916 details
HMGB2_HUMANFBX7_HUMANBioGRID27503909 details
HMGB2_HUMANKC1A_HUMANBioGRID, HPRD, MINT12062430 details
HMGB2_HUMANEIF1B_HUMANIntAct17353931 details
HMGB2_HUMANTRAF6_HUMANIntAct17353931 details
HMGB2_HUMANNFKB1_HUMANIntAct20195357 details
HMGB2_HUMANPO5F1_HUMANBioGRID, HPRD11099378 details
HMGB2_HUMANHMGB1_HUMANBioGRID12517784 24981860 26344197 details
HMGB2_HUMANU2AF2_HUMANBioGRID26641092 details
HMGB2_HUMANPSD12_HUMANBioGRID27226596 details
HMGB2_HUMANAPEX1_HUMANHPRD12524539 details
HMGB2_HUMANPO2F1_HUMANHPRD7720710 details
HMGB2_HUMANP53_HUMANHPRD11748232 details
HMGB2_HUMANPRKDC_HUMANHPRD9722660 details
HMGB2_HUMANPO3F1_HUMANHPRD7720710 details