Entity Details

Primary name UFO_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP30530
EntryNameUFO_HUMAN
FullNameTyrosine-protein kinase receptor UFO
TaxID9606
Evidenceevidence at protein level
Length894
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesAXL

GO terms

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GOName
GO:0001618 virus receptor activity
GO:0001764 neuron migration
GO:0001779 natural killer cell differentiation
GO:0001786 phosphatidylserine binding
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0001974 blood vessel remodeling
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006909 phagocytosis
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0007399 nervous system development
GO:0009986 cell surface
GO:0015629 actin cytoskeleton
GO:0016477 cell migration
GO:0021885 forebrain cell migration
GO:0030168 platelet activation
GO:0031100 animal organ regeneration
GO:0031668 cellular response to extracellular stimulus
GO:0032036 myosin heavy chain binding
GO:0032689 negative regulation of interferon-gamma production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032825 positive regulation of natural killer cell differentiation
GO:0032940 secretion by cell
GO:0033674 positive regulation of kinase activity
GO:0034101 erythrocyte homeostasis
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035457 cellular response to interferon-alpha
GO:0042698 ovulation cycle
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043235 receptor complex
GO:0043491 protein kinase B signaling
GO:0043524 negative regulation of neuron apoptotic process
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0044228 host cell surface
GO:0045087 innate immune response
GO:0046718 viral entry into host cell
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048469 cell maturation
GO:0048549 positive regulation of pinocytosis
GO:0051250 negative regulation of lymphocyte activation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060068 vagina development
GO:0070062 extracellular exosome
GO:0070301 cellular response to hydrogen peroxide
GO:0071222 cellular response to lipopolysaccharide
GO:0097028 dendritic cell differentiation
GO:0097350 neutrophil clearance
GO:1903902 positive regulation of viral life cycle
GO:2000669 negative regulation of dendritic cell apoptotic process

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule
DB12141 GilteritinibDrugbanksmall molecule

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
UFO_HUMANGAS6_HUMANBioGRID, HPRD, MINT16362042 8621659 8939948 details
UFO_HUMANGRB2_HUMANBioGRID, HPRD, MINT18346204 9178760 details
UFO_HUMANPLCG1_HUMANHPRD, MINT9178760 details
UFO_HUMANP85A_HUMANBioGRID, HPRD, MINT18346204 9178760 details
UFO_HUMANSRC_HUMANBioGRID, HPRD, MINT22327215 9178760 details
UFO_HUMANEGFR_HUMANBioGRID, IntAct25873175 27775700 details
UFO_HUMANTNS2_HUMANBioGRID, HPRD12470648 details
UFO_HUMANLCK_HUMANBioGRID, HPRD9178760 details
UFO_HUMANP85B_HUMANBioGRID, HPRD9178760 details
UFO_HUMANFBX25_HUMANBioGRID23940030 details
UFO_HUMANRANB9_HUMANBioGRID, HPRD12470648 15964779 details
UFO_HUMANTYRO3_HUMANBioGRID15964779 details
UFO_HUMANUFO_HUMANBioGRID, HPRD27775700 31980649 9178760 details
UFO_HUMANSOCS1_HUMANBioGRID, HPRD12470648 29991678 details
UFO_HUMANP55G_HUMANHPRD12470648 details
UFO_HUMANNCK2_HUMANHPRD12470648 details
UFO_HUMANHS90B_HUMANBioGRID, IntAct22939624 31980649 details
UFO_HUMANHS90A_HUMANBioGRID, IntAct22939624 23629654 31980649 details
UFO_HUMANHS71A_HUMANBioGRID, IntAct23629654 31980649 details
UFO_HUMANCBL_HUMANBioGRID, HPRD15958209 details
UFO_HUMANACK1_HUMANBioGRID19815557 details
UFO_HUMANERRFI_HUMANBioGRID19815557 details
UFO_HUMANHS71B_HUMANBioGRID23629654 31980649 details
UFO_HUMANCHIP_HUMANBioGRID23629654 details
UFO_HUMANABL2_HUMANBioGRID18346204 details
UFO_HUMANARRD3_HUMANBioGRID29416926 details
UFO_HUMANSHC1_HUMANHPRD8610109 details
UFO_HUMANPTN11_HUMANHPRD15507525 details
UFO_HUMANIL2RG_HUMANHPRD16308569 details
UFO_HUMANI15RA_HUMANHPRD16308569 details
UFO_HUMANADA10_HUMANHPRD16227584 7822279 details
UFO_HUMANSHC3_HUMANHPRD8610109 details