Entity Details

Primary name AK1C3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42330
EntryNameAK1C3_HUMAN
FullNameAldo-keto reductase family 1 member C3
TaxID9606
Evidenceevidence at protein level
Length323
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesAKR1C3

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0001758 retinal dehydrogenase activity
GO:0004032 alditol:NADP+ 1-oxidoreductase activity
GO:0004033 aldo-keto reductase (NADP) activity
GO:0004745 NAD-retinol dehydrogenase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006693 prostaglandin metabolic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007584 response to nutrient
GO:0008202 steroid metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0008584 male gonad development
GO:0009267 cellular response to starvation
GO:0010942 positive regulation of cell death
GO:0016229 steroid dehydrogenase activity
GO:0016488 farnesol catabolic process
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0018636 phenanthrene 9,10-monooxygenase activity
GO:0019371 cyclooxygenase pathway
GO:0030216 keratinocyte differentiation
GO:0032052 bile acid binding
GO:0034614 cellular response to reactive oxygen species
GO:0035410 dihydrotestosterone 17-beta-dehydrogenase activity
GO:0036130 prostaglandin H2 endoperoxidase reductase activity
GO:0036131 prostaglandin D2 11-ketoreductase activity
GO:0042448 progesterone metabolic process
GO:0042574 retinal metabolic process
GO:0043170 macromolecule metabolic process
GO:0044594 17-beta-hydroxysteroid dehydrogenase (NAD+) activity
GO:0044597 daunorubicin metabolic process
GO:0044598 doxorubicin metabolic process
GO:0045550 geranylgeranyl reductase activity
GO:0045703 ketoreductase activity
GO:0047017 prostaglandin-F synthase activity
GO:0047020 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
GO:0047023 androsterone dehydrogenase activity
GO:0047024 5alpha-androstane-3beta,17beta-diol dehydrogenase activity
GO:0047035 testosterone dehydrogenase (NAD+) activity
GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase activity
GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity
GO:0047086 ketosteroid monooxygenase activity
GO:0047787 delta4-3-oxosteroid 5beta-reductase activity
GO:0047834 D-threo-aldose 1-dehydrogenase activity
GO:0048385 regulation of retinoic acid receptor signaling pathway
GO:0051897 positive regulation of protein kinase B signaling
GO:0061370 testosterone biosynthetic process
GO:0070062 extracellular exosome
GO:0070293 renal absorption
GO:0071276 cellular response to cadmium ion
GO:0071277 cellular response to calcium ion
GO:0071379 cellular response to prostaglandin stimulus
GO:0071384 cellular response to corticosteroid stimulus
GO:0071395 cellular response to jasmonic acid stimulus
GO:0071799 cellular response to prostaglandin D stimulus
GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO:1900053 negative regulation of retinoic acid biosynthetic process
GO:2000224 regulation of testosterone biosynthetic process
GO:2000353 positive regulation of endothelial cell apoptotic process
GO:2000379 positive regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR018170 Aldo/keto reductase, conserved siteSiteConserved site
IPR020471 Aldo-keto reductaseFamilyFamily
IPR023210 NADP-dependent oxidoreductase domainDomainDomain
IPR036812 NADP-dependent oxidoreductase domain superfamilyFamilyHomologous superfamily
IPR044482 Aldo-keto reductase family 1 member CFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00328 IndomethacinDrugbanksmall molecule
DB00776 OxcarbazepineDrugbanksmall molecule
DB00959 MethylprednisoloneDrugbanksmall molecule
DB00997 DoxorubicinDrugbanksmall molecule
DB01039 FenofibrateDrugbanksmall molecule
DB01536 AndrostenedioneDrugbanksmall molecule
DB01698 RutinDrugbanksmall molecule
DB02056 Prostaglandin D2Drugbanksmall molecule
DB02266 Flufenamic acidDrugbanksmall molecule
DB03461 Nicotinamide adenine dinucleotide phosphateDrugbanksmall molecule
DB06077 LumateperoneDrugbanksmall molecule
DB07700 3-carboxamido-1,3,5(10)-estratrien-17(R)-spiro-2'(5',5'-dimethyl-6'oxo)tetrahydropyranDrugbanksmall molecule
DB13751 Glycyrrhizic acidDrugbanksmall molecule