Entity Details

Primary name BLK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51451
EntryNameBLK_HUMAN
FullNameTyrosine-protein kinase Blk
TaxID9606
Evidenceevidence at protein level
Length505
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesBLK

GO terms

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GOName
GO:0002431 Fc receptor mediated stimulatory signaling pathway
GO:0002513 tolerance induction to self antigen
GO:0002576 platelet degranulation
GO:0002902 regulation of B cell apoptotic process
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006974 cellular response to DNA damage stimulus
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030154 cell differentiation
GO:0030889 negative regulation of B cell proliferation
GO:0031175 neuron projection development
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0032024 positive regulation of insulin secretion
GO:0035556 intracellular signal transduction
GO:0043304 regulation of mast cell degranulation
GO:0045087 innate immune response
GO:0050853 B cell receptor signaling pathway
GO:0050855 regulation of B cell receptor signaling pathway
GO:0070667 negative regulation of mast cell proliferation
GO:0090330 regulation of platelet aggregation
GO:0097028 dendritic cell differentiation
GO:2000670 positive regulation of dendritic cell apoptotic process

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035853 Tyrosine-protein kinase Blk, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule

Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
BLK_HUMANERBB2_HUMANBioGRID, MINT16273093 22973453 details
BLK_HUMANEGFR_HUMANBioGRID, IntAct, MINT16273093 22973453 24658140 25402006 31980649 details
BLK_HUMANANDR_HUMANBioGRID, IntAct24728074 details
BLK_HUMANGAB1_HUMANBioGRID, IntAct24728074 details
BLK_HUMANKIT_HUMANBioGRID, IntAct24728074 details
BLK_HUMANMET_HUMANBioGRID, IntAct24728074 details
BLK_HUMANEFS_HUMANBioGRID, IntAct25416956 29892012 31515488 32296183 details
BLK_HUMANSTAT3_HUMANBioGRID, IntAct25416956 29892012 31515488 32296183 details
BLK_HUMANP85A_HUMANBioGRID, IntAct32296183 details
BLK_HUMANTRIM1_HUMANBioGRID, IntAct32296183 details
BLK_HUMANPAXI_HUMANBioGRID, IntAct32296183 details
BLK_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
BLK_HUMANTYDP2_HUMANBioGRID, IntAct32296183 details
BLK_HUMANIKZF3_HUMANBioGRID, IntAct32296183 details
BLK_HUMANZBT8A_HUMANBioGRID, IntAct32296183 details
BLK_HUMANSLAP1_HUMANBioGRID, IntAct32296183 details
BLK_HUMANSTAP2_HUMANBioGRID, IntAct32296183 details
BLK_HUMANFXR1_HUMANBioGRID, IntAct32296183 details
BLK_HUMANFXR2_HUMANBioGRID, IntAct32296183 details
BLK_HUMANP55G_HUMANBioGRID, IntAct32296183 details
BLK_HUMANSOCS3_HUMANBioGRID, IntAct32296183 details
BLK_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
BLK_HUMANSSBP3_HUMANBioGRID, IntAct32296183 details
BLK_HUMANFACC1_HUMANBioGRID, IntAct32296183 details
BLK_HUMANBIRC2_HUMANBioGRID, IntAct32296183 details
BLK_HUMANZBT42_HUMANBioGRID, IntAct32296183 details
BLK_HUMANJKIP1_HUMANBioGRID, IntAct32296183 details
BLK_HUMANGRB10_HUMANBioGRID, IntAct32296183 details
BLK_HUMANCRKL_HUMANBioGRID, IntAct32296183 details
BLK_HUMANSH21B_HUMANBioGRID, IntAct32296183 details
BLK_HUMANZN774_HUMANBioGRID, IntAct32296183 details
BLK_HUMANFLT3_HUMANMINT28086240 details
BLK_HUMANCCD33_HUMANBioGRID, IntAct25416956 31515488 32296183 details
BLK_HUMANUBE3A_HUMANBioGRID, HPRD10449731 details
BLK_HUMANBCL2_HUMANBioGRID, HPRD9525867 details
BLK_HUMANB2CL1_HUMANBioGRID9525867 details
BLK_HUMANPLCG2_HUMANBioGRID, HPRD8395016 details
BLK_HUMANFBX7_HUMANBioGRID27503909 details
BLK_HUMANSKAP2_HUMANBioGRID29568343 details
BLK_HUMANZBT32_HUMANBioGRID32296183 details
BLK_HUMANZMAT1_HUMANBioGRID32296183 details
BLK_HUMANERBB3_HUMANBioGRID22973453 details
BLK_HUMANERBB4_HUMANBioGRID22973453 details
BLK_HUMANSOCS1_HUMANBioGRID31101761 details
BLK_HUMANSPF27_HUMANHPRD12406557 details
BLK_HUMANCBL_HUMANBioGRID, HPRD, MINT8083187 8621719 details
BLK_HUMANHS90B_HUMANBioGRID, IntAct22939624 31980649 details
BLK_HUMANVIME_HUMANBioGRID, IntAct31980649 details
BLK_HUMANBANK1_HUMANUniProt21978998 details
BLK_HUMANCD79A_HUMANBioGRID, HPRD7592958 details
BLK_HUMANCD79B_HUMANBioGRID, HPRD7592958 details
BLK_HUMANTRAF3_HUMANBioGRID32779804 details
BLK_HUMANTULP3_HUMANBioGRID33187986 details
BLK_HUMANCTR9_HUMANHPRD8636124 details
BLK_HUMANFCG2B_HUMANHPRD8756631 details
BLK_HUMANFCG2A_HUMANHPRD8756631 details
BLK_HUMANBCR_HUMANHPRD8756631 details