Entity Details

Primary name CCR5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51681
EntryNameCCR5_HUMAN
FullNameC-C chemokine receptor type 5
TaxID9606
Evidenceevidence at protein level
Length352
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesCCR5

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001618 virus receptor activity
GO:0002407 dendritic cell chemotaxis
GO:0003779 actin binding
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004950 chemokine receptor activity
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006816 calcium ion transport
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006968 cellular defense response
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0015026 coreceptor activity
GO:0016493 C-C chemokine receptor activity
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019722 calcium-mediated signaling
GO:0019957 C-C chemokine binding
GO:0023052 signaling
GO:0042802 identical protein binding
GO:0044409 entry into host
GO:0060326 cell chemotaxis
GO:0070723 response to cholesterol
GO:0071222 cellular response to lipopolysaccharide
GO:0071791 chemokine (C-C motif) ligand 5 binding

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000355 Chemokine receptor familyFamilyFamily
IPR002240 CC chemokine receptor 5FamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB04835 MaravirocDrugbanksmall molecule
DB05501 AMD-070Drugbanksmall molecule
DB05906 CCR5 mAbDrugbankbiotech
DB05941 LeronlimabDrugbankbiotech
DB06497 AplavirocDrugbanksmall molecule
DB06652 VicrivirocDrugbanksmall molecule
DB12698 IbalizumabDrugbankbiotech
DB12960 INCB-9471Drugbanksmall molecule

Interactions

50 interactions

InteractorPartnerSourcesPublicationsLink
CCR5_HUMANCXCR4_HUMANBioGRID, DIP, HPRD, IntAct12429730 15660419 18632580 details
CCR5_HUMANPRAF2_HUMANHPRD, MINT15757671 details
CCR5_HUMANCREB3_HUMANIntAct15001559 details
CCR5_HUMANCTBP2_HUMANBioGRID, IntAct21988832 details
CCR5_HUMANETV5_HUMANBioGRID, IntAct21988832 details
CCR5_HUMANIL24_HUMANBioGRID, IntAct21988832 details
CCR5_HUMANCST9L_HUMANBioGRID, IntAct21988832 details
CCR5_HUMANCCL5_HUMANbhf-ucl, BioGRID, HPRD, MINT10477718 11116158 11449371 14637022 23480650 28381538 8663314 9289016 details
CCR5_HUMANEMP1_HUMANBioGRID, IntAct32296183 details
CCR5_HUMANCCR5_HUMANDIP, HPRD, IntAct12065593 12176010 18230715 18632580 23121557 details
CCR5_HUMANS20A2_HUMANBioGRID, MINT28298427 details
CCR5_HUMANACKR1_HUMANIntAct18230715 details
CCR5_HUMANARRB1_HUMANBioGRID, HPRD12065593 details
CCR5_HUMANCCL3_HUMANBioGRID, HPRD10477718 11700073 details
CCR5_HUMANCL3L1_HUMANBioGRID, HPRD10364178 11449371 11734558 details
CCR5_HUMANPSA5_HUMANBioGRID, HPRD11877445 details
CCR5_HUMANCD4_HUMANBioGRID, DIP, HPRD, IntAct, UniProt10816381 15660419 30542158 details
CCR5_HUMANPRAF3_HUMANHPRD, MINT15757671 details
CCR5_HUMANMYH9_HUMANIntAct12421915 details
CCR5_HUMANCCL17_HUMANbhf-ucl28381538 details
CCR5_HUMANFAK1_HUMANBioGRID10384144 details
CCR5_HUMANFETA_HUMANBioGRID, HPRD12176010 details
CCR5_HUMANJAK2_HUMANBioGRID, HPRD11278738 11591716 details
CCR5_HUMANSTAT3_HUMANBioGRID, HPRD11350939 14674010 details
CCR5_HUMANSTA5B_HUMANBioGRID11350939 details
CCR5_HUMANP85B_HUMANBioGRID11350939 details
CCR5_HUMANCCL4_HUMANHPRD12427015 8663314 details
CCR5_HUMANTXK_HUMANHPRD11859127 details
CCR5_HUMANARBK2_HUMANHPRD10085131 details
CCR5_HUMANCCL11_HUMANHPRD10477718 11264152 details
CCR5_HUMANFAK2_HUMANHPRD9446638 details
CCR5_HUMANCCR2_HUMANHPRD11350939 details
CCR5_HUMANCCL13_HUMANHPRD10477718 details
CCR5_HUMANCCL14_HUMANHPRD11085751 details
CCR5_HUMANCCL16_HUMANHPRD11470772 details
CCR5_HUMANCCL8_HUMANHPRD10477718 9468473 details
CCR5_HUMANDYN2_HUMANHPRD10477567 details
CCR5_HUMANGNAI1_HUMANHPRD15251452 details
CCR5_HUMANGNAO_HUMANHPRD15251452 details
CCR5_HUMANGNAI2_HUMANHPRD15251452 details
CCR5_HUMANGNAI3_HUMANHPRD15251452 details
CCR5_HUMANJAK1_HUMANHPRD10037796 details
CCR5_HUMANSTAT1_HUMANHPRD14674010 details
CCR5_HUMANGNAQ_HUMANHPRD15251452 details
CCR5_HUMANARBK1_HUMANHPRD10085131 details
CCR5_HUMANSTA5A_HUMANHPRD10037796 details
CCR5_HUMANA1AG1_HUMANHPRD11336643 details
CCR5_HUMANLCK_HUMANHPRD11591716 details
CCR5_HUMANCCL2_HUMANHPRD10477718 details
CCR5_HUMANCCL7_HUMANHPRD10477718 details