Entity Details

Primary name HME1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ05925
EntryNameHME1_HUMAN
FullNameHomeobox protein engrailed-1
TaxID9606
Evidenceinferred from homology
Length392
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesEN1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001501 skeletal system development
GO:0005634 nucleus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008344 adult locomotory behavior
GO:0009653 anatomical structure morphogenesis
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0016020 membrane
GO:0021549 cerebellum development
GO:0030182 neuron differentiation
GO:0030901 midbrain development
GO:0030917 midbrain-hindbrain boundary development
GO:0035115 embryonic forelimb morphogenesis
GO:0035176 social behavior
GO:0035264 multicellular organism growth
GO:0042220 response to cocaine
GO:0042756 drinking behavior
GO:0043473 pigmentation
GO:0043524 negative regulation of neuron apoptotic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048666 neuron development
GO:0061743 motor learning
GO:0071542 dopaminergic neuron differentiation
GO:1990403 embryonic brain development
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000747 Homeobox domain engrailedDomainDomain
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site
IPR019549 Homeobox engrailed, C-terminalDomainDomain
IPR019737 Homeobox engrailed-type, conserved siteSiteConserved site
IPR020479 Homeobox domain, metazoaDomainDomain

Diseases

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Interactions

3 interactions