Entity Details

Primary name TIAM1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13009
EntryNameTIAM1_HUMAN
FullNameRho guanine nucleotide exchange factor TIAM1
TaxID9606
Evidenceevidence at protein level
Length1591
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesTIAM1

GO terms

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GOName
GO:0003300 cardiac muscle hypertrophy
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006915 apoptotic process
GO:0007160 cell-matrix adhesion
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0008017 microtubule binding
GO:0008284 positive regulation of cell population proliferation
GO:0008289 lipid binding
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0016020 membrane
GO:0016477 cell migration
GO:0016601 Rac protein signal transduction
GO:0019900 kinase binding
GO:0030335 positive regulation of cell migration
GO:0030971 receptor tyrosine kinase binding
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0032092 positive regulation of protein binding
GO:0032587 ruffle membrane
GO:0034622 cellular protein-containing complex assembly
GO:0042220 response to cocaine
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043197 dendritic spine
GO:0043507 positive regulation of JUN kinase activity
GO:0044291 cell-cell contact zone
GO:0044295 axonal growth cone
GO:0044304 main axon
GO:0045202 synapse
GO:0048013 ephrin receptor signaling pathway
GO:0050772 positive regulation of axonogenesis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0072657 protein localization to membrane
GO:0090630 activation of GTPase activity
GO:0098978 glutamatergic synapse
GO:0098989 NMDA selective glutamate receptor signaling pathway
GO:0099147 extrinsic component of postsynaptic density membrane
GO:1904268 positive regulation of Schwann cell chemotaxis
GO:1904338 regulation of dopaminergic neuron differentiation
GO:1905274 regulation of modification of postsynaptic actin cytoskeleton
GO:1990138 neuron projection extension
GO:2000050 regulation of non-canonical Wnt signaling pathway

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved siteSiteConserved site
IPR001478 PDZ domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR003116 Raf-like Ras-bindingDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR033360 T-lymphoma invasion and metastasis-inducing protein 1FamilyFamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR040655 TIAM1, CC-Ex domainDomainDomain
IPR043537 Tiam1/Tiam2/Protein still lifeFamilyFamily

Diseases

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Interactions

93 interactions

InteractorPartnerSourcesPublicationsLink
TIAM1_HUMANCNTP4_HUMANDIP23395182 details
TIAM1_HUMANSDC1_HUMANDIP23395182 details
TIAM1_HUMANSDC3_HUMANDIP23395182 details
TIAM1_HUMANSDC4_HUMANDIP23395182 details
TIAM1_HUMANSDC2_HUMANDIP23395182 details
TIAM1_HUMANNEB2_HUMANBioGRID, HPRD12531897 details
TIAM1_HUMANRAC1_HUMANBioGRID, HPRD11130063 11595749 32203420 details
TIAM1_HUMANMYC_HUMANBioGRID, HPRD12446731 details
TIAM1_HUMANCD44_HUMANBioGRID, HPRD10636882 details
TIAM1_HUMANKPCA_HUMANBioGRID, HPRD10212259 details
TIAM1_HUMANKPCB_HUMANBioGRID10212259 details
TIAM1_HUMANKPCG_HUMANBioGRID, HPRD10212259 details
TIAM1_HUMANKPCE_HUMANBioGRID, HPRD10212259 details
TIAM1_HUMANKPCD_HUMANBioGRID, HPRD10212259 details
TIAM1_HUMANKPCZ_HUMANBioGRID10212259 details
TIAM1_HUMANANK1_HUMANBioGRID, HPRD10893266 details
TIAM1_HUMANUBC_HUMANBioGRID23314748 details
TIAM1_HUMANFBW1A_HUMANBioGRID25124033 details
TIAM1_HUMANKC1A_HUMANBioGRID25124033 details
TIAM1_HUMANPSA7_HUMANBioGRID28292943 details
TIAM1_HUMANOSBL1_HUMANBioGRID29739365 details
TIAM1_HUMANZKSC4_HUMANBioGRID29739365 details
TIAM1_HUMANFND3B_HUMANBioGRID29739365 details
TIAM1_HUMANSRSF5_HUMANBioGRID29739365 details
TIAM1_HUMANSYCP1_HUMANBioGRID29739365 details
TIAM1_HUMANSETB1_HUMANBioGRID29739365 details
TIAM1_HUMANPP2AA_HUMANBioGRID14744259 details
TIAM1_HUMANCDC42_HUMANBioGRID32203420 details
TIAM1_HUMANRHOA_HUMANBioGRID32203420 details
TIAM1_HUMANCBP_HUMANBioGRID32238831 details
TIAM1_HUMAN1433G_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 28514442 details
TIAM1_HUMANPARD3_HUMANDIP, HPRD, MINT15723052 17053785 23263278 details
TIAM1_HUMANCSKP_HUMANIntAct21763699 details
TIAM1_HUMANDCLK1_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANSI1L1_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANKIF1C_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANMAST3_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANSRGP2_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANGGYF1_HUMANIntActunassigned1312 details
TIAM1_HUMANNADK_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANNF1_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANHDAC4_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANPPM1H_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANINP5E_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANRTKN_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANSIN1_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANDEN1A_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANKSR1_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANPHLB2_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANDEN4C_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANSPD2A_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANM3K21_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANZN638_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANCAMP2_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANCDK16_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANMPIP3_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANMPIP2_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANIF4E2_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANAN34A_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANPKHA7_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANGGYF2_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANSYDE1_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANF110B_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANSRS12_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANMAGI1_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANTESK2_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANF110A_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANKI13B_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANFA53C_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANLRFN1_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANCING_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANLIMA1_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANNGAP_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANUBP21_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANZBT21_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANAGAP1_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANCBY1_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANKCTD3_HUMANBioGRID, IntAct27173435 unassigned1312 details
TIAM1_HUMANJIP2_HUMANBioGRID, HPRD12024021 details
TIAM1_HUMANJIP1_HUMANBioGRID, HPRD12024021 details
TIAM1_HUMANRASH_HUMANBioGRID, HPRD12134164 details
TIAM1_HUMANANK3_HUMANBioGRID10893266 details
TIAM1_HUMANNDKA_HUMANBioGRID, HPRD11274357 details
TIAM1_HUMANNSD2_HUMANBioGRID22028615 details
TIAM1_HUMAN1433E_HUMANBioGRID17979178 details
TIAM1_HUMANKC1E_HUMANBioGRID25124033 details
TIAM1_HUMANKBTB6_HUMANBioGRID25684205 details
TIAM1_HUMANKBTB7_HUMANBioGRID25684205 details
TIAM1_HUMANEPHA2_HUMANHPRD14988728 details
TIAM1_HUMANSRC_HUMANHPRD12810717 details
TIAM1_HUMANEFNB1_HUMANHPRD14988728 details
TIAM1_HUMANTIAM1_HUMANHPRD12376551 14988728 details
TIAM1_HUMANABCA1_HUMANHPRD16192287 details