Entity Details

Primary name SIRPA
Entity type gene
Source Source Link

Details

PrimaryID140885
RefseqGene
SymbolSIRPA
Namesignal regulatory protein alpha
Chromosome20
Location20p13
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2002-01-15
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSHPS1_HUMAN

GO terms

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GOName
GO:0001933 negative regulation of protein phosphorylation
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007155 cell adhesion
GO:0009986 cell surface
GO:0010468 regulation of gene expression
GO:0016020 membrane
GO:0016477 cell migration
GO:0017124 SH3 domain binding
GO:0019903 protein phosphatase binding
GO:0030695 GTPase regulator activity
GO:0032649 regulation of interferon-gamma production
GO:0032651 regulation of interleukin-1 beta production
GO:0032675 regulation of interleukin-6 production
GO:0032680 regulation of tumor necrosis factor production
GO:0032688 negative regulation of interferon-beta production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0035696 monocyte extravasation
GO:0043312 neutrophil degranulation
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045428 regulation of nitric oxide biosynthetic process
GO:0046329 negative regulation of JNK cascade
GO:0050728 negative regulation of inflammatory response
GO:0050765 negative regulation of phagocytosis
GO:0050766 positive regulation of phagocytosis
GO:0050870 positive regulation of T cell activation
GO:0050900 leukocyte migration
GO:0070062 extracellular exosome
GO:0070301 cellular response to hydrogen peroxide
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070821 tertiary granule membrane
GO:0071222 cellular response to lipopolysaccharide
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071349 cellular response to interleukin-12
GO:0071641 negative regulation of macrophage inflammatory protein 1 alpha production
GO:0071650 negative regulation of chemokine (C-C motif) ligand 5 production
GO:0086080 protein binding involved in heterotypic cell-cell adhesion
GO:0098632 cell-cell adhesion mediator activity
GO:0101003 ficolin-1-rich granule membrane
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:1903720 negative regulation of I-kappaB phosphorylation
GO:1990405 protein antigen binding
GO:1990782 protein tyrosine kinase binding

Diseases

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Interactions

80 interactions

InteractorPartnerSourcesPublicationsLink
SIRPANOL3BioGRID, HPRD, IntAct16189514 32296183 details
SIRPATRIM2BioGRID, HPRD, IntAct16189514 25416956 32296183 details
SIRPAPTPN6BioGRID, HPRD, UniProt10660565 10660620 14662855 8943344 9632768 details
SIRPAINPP5DUniProt24642916 details
SIRPACD47HPRD, IntAct16291597 17070842 9872987 details
SIRPAPTPN11BioGRID, HPRD, IntAct10962556 15888547 19299420 20473329 8943344 details
SIRPAKRT15BioGRID25416956 details
SIRPAKRT31BioGRID25416956 32296183 details
SIRPATRIM27BioGRID25416956 details
SIRPAKRT40BioGRID25416956 details
SIRPACCDC57BioGRID25416956 32296183 details
SIRPAMATKBioGRID17999719 19299420 21799000 details
SIRPAIGF1RBioGRID21799000 details
SIRPAHSPA8BioGRID19299420 details
SIRPAHSPA5BioGRID19299420 details
SIRPACCT6ABioGRID19299420 details
SIRPAHSP90AB1BioGRID19299420 details
SIRPACALRBioGRID19299420 details
SIRPAHSPA1ABioGRID19299420 details
SIRPAHSP90B1BioGRID19299420 details
SIRPAHSPA9BioGRID19299420 details
SIRPAEIF5BBioGRID19299420 details
SIRPARPS8BioGRID19299420 details
SIRPAELOABioGRID19299420 details
SIRPAFUBP1BioGRID19299420 details
SIRPASAFB2BioGRID19299420 details
SIRPASUPT6HBioGRID19299420 details
SIRPADDX10BioGRID19299420 details
SIRPADDX6BioGRID19299420 details
SIRPASTAT1BioGRID19299420 details
SIRPATBX3BioGRID19299420 details
SIRPAILKBioGRID19299420 details
SIRPANEK1BioGRID19299420 details
SIRPACDK16BioGRID19299420 details
SIRPAPTPN7BioGRID19299420 details
SIRPAPTPRABioGRID19299420 details
SIRPAPPM1BBioGRID19299420 details
SIRPAAKT1BioGRID19299420 details
SIRPAKTN1BioGRID19299420 details
SIRPAARF4BioGRID19299420 details
SIRPAGNL1BioGRID19299420 details
SIRPAMX1BioGRID19299420 details
SIRPAACTN1BioGRID19299420 details
SIRPAVIMBioGRID19299420 details
SIRPAFLNABioGRID19299420 details
SIRPAPFN1BioGRID19299420 details
SIRPAKRT2BioGRID19299420 details
SIRPAKRT10BioGRID19299420 details
SIRPACAPZBBioGRID19299420 details
SIRPANEXNBioGRID19299420 details
SIRPAND1BioGRID19299420 details
SIRPAPHYHBioGRID19299420 details
SIRPANOX4BioGRID19299420 details
SIRPATPT1BioGRID19299420 details
SIRPANUCB1BioGRID19299420 details
SIRPAFTH1BioGRID19299420 details
SIRPACOL6A2BioGRID19299420 details
SIRPACD81BioGRID19299420 details
SIRPAARHGEF6BioGRID19299420 details
SIRPAPSMA6BioGRID19299420 details
SIRPAPSMC5BioGRID19299420 details
SIRPASOS1BioGRID19299420 details
SIRPASMG7BioGRID19299420 details
SIRPAHSPA4BioGRID19299420 details
SIRPATRIM23BioGRID32296183 details
SIRPAKRT34BioGRID32296183 details
SIRPADYNLT1BioGRID32296183 details
SIRPAHSF2BPBioGRID32296183 details
SIRPAJAK2BioGRID, HPRD10842184 details
SIRPASHC1BioGRID15888547 details
SIRPAIL1RAPHPRD12483539 details
SIRPAGRB2BioGRID, IntAct21706016 details
SIRPAHTTIntAct17500595 details
SIRPASIRPGBioGRID, IntAct26186194 28514442 details
SIRPACDH1BioGRID25468996 details
SIRPARNF4BioGRID29180619 details
SIRPAKRASBioGRID30194290 30639242 34079125 details
SIRPAHRASBioGRID30194290 details
SIRPANRASBioGRID30194290 details
SIRPARHOBBioGRID34079125 details