Entity Details

Primary name HES1
Entity type gene
Source Source Link

Details

PrimaryID3280
RefseqGene
SymbolHES1
Namehes family bHLH transcription factor 1
Chromosome3
Location3q29
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1994-04-20
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsHES1_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001889 liver development
GO:0003143 embryonic heart tube morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003266 regulation of secondary heart field cardioblast proliferation
GO:0003281 ventricular septum development
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007155 cell adhesion
GO:0007219 Notch signaling pathway
GO:0007224 smoothened signaling pathway
GO:0007399 nervous system development
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0009952 anterior/posterior pattern specification
GO:0016477 cell migration
GO:0021537 telencephalon development
GO:0021555 midbrain-hindbrain boundary morphogenesis
GO:0021557 oculomotor nerve development
GO:0021558 trochlear nerve development
GO:0021575 hindbrain morphogenesis
GO:0021861 forebrain radial glial cell differentiation
GO:0021984 adenohypophysis development
GO:0030324 lung development
GO:0030513 positive regulation of BMP signaling pathway
GO:0030901 midbrain development
GO:0031016 pancreas development
GO:0032991 protein-containing complex
GO:0035019 somatic stem cell population maintenance
GO:0035910 ascending aorta morphogenesis
GO:0042102 positive regulation of T cell proliferation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043388 positive regulation of DNA binding
GO:0043398 HLH domain binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0045598 regulation of fat cell differentiation
GO:0045608 negative regulation of inner ear auditory receptor cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045977 positive regulation of mitotic cell cycle, embryonic
GO:0046331 lateral inhibition
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0048469 cell maturation
GO:0048538 thymus development
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048711 positive regulation of astrocyte differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0048844 artery morphogenesis
GO:0050678 regulation of epithelial cell proliferation
GO:0050767 regulation of neurogenesis
GO:0051087 chaperone binding
GO:0060122 inner ear receptor cell stereocilium organization
GO:0060164 regulation of timing of neuron differentiation
GO:0060253 negative regulation of glial cell proliferation
GO:0060412 ventricular septum morphogenesis
GO:0060675 ureteric bud morphogenesis
GO:0060716 labyrinthine layer blood vessel development
GO:0061009 common bile duct development
GO:0061106 negative regulation of stomach neuroendocrine cell differentiation
GO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061626 pharyngeal arch artery morphogenesis
GO:0065003 protein-containing complex assembly
GO:0070888 E-box binding
GO:0071820 N-box binding
GO:0072012 glomerulus vasculature development
GO:0072049 comma-shaped body morphogenesis
GO:0072050 S-shaped body morphogenesis
GO:0072141 renal interstitial fibroblast development
GO:0072282 metanephric nephron tubule morphogenesis
GO:0090102 cochlea development
GO:0090162 establishment of epithelial cell polarity
GO:0097084 vascular associated smooth muscle cell development
GO:0097150 neuronal stem cell population maintenance
GO:1905934 negative regulation of cell fate determination
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000227 negative regulation of pancreatic A cell differentiation
GO:2000737 negative regulation of stem cell differentiation
GO:2000974 negative regulation of pro-B cell differentiation
GO:2000978 negative regulation of forebrain neuron differentiation

Diseases

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Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
HES1ASGR2BioGRID, IntAct21988832 details
HES1LTBRBioGRID, IntAct21988832 details
HES1APH1ABioGRID, IntAct21988832 details
HES1SIRT1BioGRID, HPRD, UniProt12535671 details
HES1APCSBioGRID, MINT21900206 details
HES1TPTEP2-CSNK1EMINT21900206 details
HES1CSNK1EBioGRID, MINT21900206 details
HES1FHL1BioGRID, MINT21900206 details
HES1GAPDHBioGRID, MINT21900206 details
HES1HDAC6BioGRID, MINT21900206 details
HES1HMGCLBioGRID, MINT21900206 details
HES1NR4A1BioGRID, MINT21900206 details
HES1NUDT3BioGRID, MINT21900206 details
HES1PTK2BioGRID, MINT21900206 details
HES1YWHABBioGRID, MINT21900206 details
HES1HEY2BioGRID, HPRD11486045 details
HES1TLE2BioGRID9874198 details
HES1FANCFBioGRID, HPRD18550849 19321451 details
HES1FANCGBioGRID, HPRD18550849 19321451 details
HES1FANCLBioGRID, HPRD18550849 details
HES1FANCABioGRID, HPRD18550849 19321451 details
HES1FANCEBioGRID, HPRD18550849 19321451 26277624 details
HES1TLE1BioGRID, HPRD18611861 19321451 8687460 details
HES1STAT3BioGRID, HPRD15156153 details
HES1HEY1BioGRID19802006 26068074 27129302 details
HES1NHLH2BioGRID21573214 details
HES1UBQLN1HPRD15492808 details
HES1ID3HPRD11756408 details
HES1ID2HPRD11756408 details
HES1ID1HPRD11756408 details
HES1ID4HPRD11756408 details
HES1RUNX2BioGRID16195230 details
HES1HDAC1BioGRID16195230 details
HES1FANCCBioGRID18550849 details
HES1HSPA4BioGRID18550849 details
HES1HSP90AA1BioGRID18550849 details
HES1SPTAN1BioGRID18550849 details
HES1PARP1BioGRID21224467 details
HES1JAK2BioGRID, HPRD15156153 details
HES1HES1BioGRID19321451 details
HES1LMO3BioGRID21573214 details
HES1CUL1BioGRID29070679 details
HES1SKP1BioGRID29070679 details
HES1FBXL14BioGRID29070679 details
HES1UBCBioGRID29463306 details
HES1HMGB1HPRD11748221 details
HES1FOXG1HPRD11238932 details
HES1PRKCAHPRD9389649 details
HES1HES6HPRD10851137 details
HES1HEXIM1BioGRID29845934 details
HES1LMNABioGRID30419336 details
HES1NOTCH1IntAct19151708 details
HES1MYCIntAct24951594 details
HES1SIN3BIntAct24951594 details
HES1RBPJIntAct24244701 details
HES1ELAVL1BioGRID19322201 details
HES1TNIP2BioGRID27609421 details