Entity Details

Primary name DHC24_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15392
EntryNameDHC24_HUMAN
FullNameDelta(24)-sterol reductase
TaxID9606
Evidenceevidence at protein level
Length516
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesDHCR24

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000246 delta24(24-1) sterol reductase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006695 cholesterol biosynthetic process
GO:0006915 apoptotic process
GO:0006979 response to oxidative stress
GO:0008202 steroid metabolic process
GO:0009888 tissue development
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0019899 enzyme binding
GO:0033489 cholesterol biosynthetic process via desmosterol
GO:0033490 cholesterol biosynthetic process via lathosterol
GO:0042605 peptide antigen binding
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043588 skin development
GO:0050614 delta24-sterol reductase activity
GO:0071949 FAD binding
GO:1901214 regulation of neuron death

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR006094 FAD linked oxidase, N-terminalDomainDomain
IPR016166 FAD-binding domain, PCMH-typeDomainDomain
IPR016169 FAD-binding, type PCMH, subdomain 2FamilyHomologous superfamily
IPR036318 FAD-binding, type PCMH-like superfamilyFamilyHomologous superfamily
IPR040165 Delta(24)-sterol reductaseFamilyFamily

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
DHC24_HUMANCCR4_HUMANBioGRID, MINT28298427 details
DHC24_HUMANDISC1_HUMANIntAct31413325 details
DHC24_HUMANP53_HUMANBioGRID, HPRD15577914 32807901 details