Entity Details

Primary name FOXP3
Entity type gene
Source Source Link

Details

PrimaryID50943
RefseqGeneNG_007392
SymbolFOXP3
Nameforkhead box P3
ChromosomeX
LocationXp11.23
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-05-08
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsFOXP3_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001782 B cell homeostasis
GO:0001818 negative regulation of cytokine production
GO:0002262 myeloid cell homeostasis
GO:0002362 CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
GO:0002456 T cell mediated immunity
GO:0002513 tolerance induction to self antigen
GO:0002667 regulation of T cell anergy
GO:0002669 positive regulation of T cell anergy
GO:0002677 negative regulation of chronic inflammatory response
GO:0002725 negative regulation of T cell cytokine production
GO:0002851 positive regulation of peripheral T cell tolerance induction
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006338 chromatin remodeling
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008285 negative regulation of cell population proliferation
GO:0009314 response to radiation
GO:0009615 response to virus
GO:0010467 gene expression
GO:0014045 establishment of endothelial blood-brain barrier
GO:0030111 regulation of Wnt signaling pathway
GO:0031064 negative regulation of histone deacetylation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032496 response to lipopolysaccharide
GO:0032689 negative regulation of interferon-gamma production
GO:0032693 negative regulation of interleukin-10 production
GO:0032700 negative regulation of interleukin-17 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032713 negative regulation of interleukin-4 production
GO:0032714 negative regulation of interleukin-5 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032753 positive regulation of interleukin-4 production
GO:0032792 negative regulation of CREB transcription factor activity
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0032914 positive regulation of transforming growth factor beta1 production
GO:0032991 protein-containing complex
GO:0033092 positive regulation of immature T cell proliferation in thymus
GO:0035035 histone acetyltransferase binding
GO:0035066 positive regulation of histone acetylation
GO:0035067 negative regulation of histone acetylation
GO:0042110 T cell activation
GO:0042130 negative regulation of T cell proliferation
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043029 T cell homeostasis
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0045589 regulation of regulatory T cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046007 negative regulation of activated T cell proliferation
GO:0046872 metal ion binding
GO:0048294 negative regulation of isotype switching to IgE isotypes
GO:0048302 regulation of isotype switching to IgG isotypes
GO:0050687 negative regulation of defense response to virus
GO:0050777 negative regulation of immune response
GO:0050852 T cell receptor signaling pathway
GO:0051059 NF-kappaB binding
GO:0051525 NFAT protein binding
GO:1901355 response to rapamycin
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000320 negative regulation of T-helper 17 cell differentiation

Diseases

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Interactions

116 interactions

InteractorPartnerSourcesPublicationsLink
FOXP3PRR20ABioGRID, IntAct25416956 25910212 29892012 31515488 32296183 details
FOXP3PRR20BBioGRID, IntAct25416956 25910212 29892012 31515488 32296183 details
FOXP3PRR20CBioGRID, IntAct25416956 25910212 29892012 31515488 32296183 details
FOXP3PRR20DBioGRID, IntAct25416956 25910212 29892012 31515488 32296183 details
FOXP3PRR20EBioGRID, IntAct25416956 25910212 29892012 31515488 32296183 details
FOXP3RBPMSBioGRID, IntAct25416956 25910212 29892012 31515488 details
FOXP3PIM1IntAct25096571 details
FOXP3STUB1BioGRID, IntAct23973223 33209884 details
FOXP3RUNX1BioGRID, DIP, HPRD17377532 details
FOXP3RORAIntAct18354202 details
FOXP3FOSBBioGRID, IntAct32296183 details
FOXP3KRTAP8-1BioGRID, IntAct32296183 details
FOXP3KRTAP3-3BioGRID, IntAct32296183 details
FOXP3KRTAP6-2BioGRID, IntAct32296183 details
FOXP3IKZF4BioGRID19696312 details
FOXP3KAT8BioGRID22152480 details
FOXP3SIVA1BioGRID21955384 details
FOXP3EP300BioGRID16652169 19996091 details
FOXP3NLKBioGRID30917315 details
FOXP3MDM2BioGRID32636834 details
FOXP3IKZF3BioGRID, InnateDB20676092 details
FOXP3HDAC2BioGRID, MINT19276356 25609649 details
FOXP3PPP1CAIntAct23396208 details
FOXP3RELBioGRID, IntAct20064449 21490927 details
FOXP3HDAC1BioGRID, IntAct21974802 24944246 details
FOXP3NFATC2BioGRID, HPRD, IntAct15790681 16517728 19564342 details
FOXP3RORCDIP18368049 details
FOXP3RELABioGRID, IntAct15790681 25712342 details
FOXP3ZFP90IntAct23543754 details
FOXP3KAT5BioGRID, DIP17360565 19996091 details
FOXP3HDAC7BioGRID, DIP17360565 details
FOXP3HDAC9BioGRID, DIP17360565 details
FOXP3USP44BioGRID, MINT32644293 details
FOXP3HDAC4BioGRID19276356 details
FOXP3NFATC1BioGRID15790681 21490927 details
FOXP3H1-5BioGRID21654845 details
FOXP3GATA3BioGRID23395819 details
FOXP3SIRT1BioGRID19996091 details
FOXP3USP7BioGRID30917315 details
FOXP3NFAT5HPRD15790681 details
FOXP3NACC1BioGRID, MINT25609649 details
FOXP3NOVA2BioGRID, MINT25609649 details
FOXP3ZBTB34BioGRID, MINT25609649 details
FOXP3SATB2BioGRID, MINT25609649 details
FOXP3NACC2BioGRID, MINT25609649 details
FOXP3BEND3BioGRID, MINT25609649 details
FOXP3HOXC13BioGRID, MINT25609649 details
FOXP3FUBP3BioGRID, MINT25609649 details
FOXP3SMC2BioGRID, MINT25609649 details
FOXP3FOXP3MINT25609649 details
FOXP3NOVA1BioGRID, MINT25609649 details
FOXP3ESRP2BioGRID, MINT25609649 details
FOXP3ZBTB37BioGRID, MINT25609649 details
FOXP3TFCP2BioGRID, MINT25609649 details
FOXP3NUP107BioGRID, MINT25609649 details
FOXP3HIPK1BioGRID, MINT25609649 details
FOXP3SATB1BioGRID, MINT25609649 details
FOXP3FEN1BioGRID, MINT25609649 details
FOXP3UBP1BioGRID, MINT25609649 details
FOXP3ZFRBioGRID, MINT25609649 details
FOXP3WRNIP1BioGRID, MINT25609649 details
FOXP3NUP133BioGRID, MINT25609649 details
FOXP3SMC3BioGRID, MINT25609649 details
FOXP3AKAP8BioGRID, MINT25609649 details
FOXP3CDC27BioGRID, MINT25609649 details
FOXP3FOXP4BioGRID, IntAct, MINT25609649 28514442 details
FOXP3ELP3BioGRID, MINT25609649 details
FOXP3P4HA1BioGRID, MINT25609649 details
FOXP3RALYBioGRID, MINT25609649 details
FOXP3ZBTB33BioGRID, MINT25609649 details
FOXP3FOXP2BioGRID, IntAct, MINT25609649 28514442 details
FOXP3ZNF326BioGRID, MINT25609649 details
FOXP3NRF1BioGRID, MINT25609649 details
FOXP3ADARBioGRID, MINT25609649 details
FOXP3NUP160BioGRID, MINT25609649 details
FOXP3CENPBBioGRID, MINT25609649 details
FOXP3CCAR2BioGRID, MINT25609649 details
FOXP3FOXR1BioGRID, MINT25609649 details
FOXP3FOXA3BioGRID, MINT25609649 details
FOXP3PSMB4BioGRID, MINT25609649 details
FOXP3FOXP1BioGRID, IntAct, MINT25609649 28514442 details
FOXP3ALBBioGRID, MINT25609649 details
FOXP3PSMA5BioGRID, MINT25609649 details
FOXP3USP11BioGRID, MINT25609649 details
FOXP3HSPA8IntAct23973223 details
FOXP3TNFIntAct25712342 details
FOXP3TRIM28IntAct23543754 details
FOXP3CDC23BioGRID, IntAct28514442 details
FOXP3SMYD2BioGRID, IntAct28514442 details
FOXP3HOXD13BioGRID25609649 details
FOXP3SUGP2BioGRID25609649 details
FOXP3STAT1IntAct19124747 details
FOXP3STAT3IntAct19124747 details
FOXP3H4-16IntAct16517728 19124747 22896699 24944246 details
FOXP3H4C15IntAct16517728 19124747 22896699 24944246 details
FOXP3H4C9IntAct16517728 19124747 22896699 24944246 details
FOXP3H4C1IntAct16517728 19124747 22896699 24944246 details
FOXP3H4C4IntAct16517728 19124747 22896699 24944246 details
FOXP3H4C6IntAct16517728 19124747 22896699 24944246 details
FOXP3H4C12IntAct16517728 19124747 22896699 24944246 details
FOXP3H4C11IntAct16517728 19124747 22896699 24944246 details
FOXP3H4C3IntAct16517728 19124747 22896699 24944246 details
FOXP3H4C8IntAct16517728 19124747 22896699 24944246 details
FOXP3H4C2IntAct16517728 19124747 22896699 24944246 details
FOXP3H4C5IntAct16517728 19124747 22896699 24944246 details
FOXP3H4C13IntAct16517728 19124747 22896699 24944246 details
FOXP3H4C14IntAct16517728 19124747 22896699 24944246 details
FOXP3IL2IntAct23396208 23543754 25096571 details
FOXP3KAT2BIntAct22896699 details
FOXP3KLF10IntAct22896699 24944246 details
FOXP3IRF1IntAct18641303 details
FOXP3SIN3AIntAct24944246 details
FOXP3HSPA1ABioGRID, IntAct23973223 details
FOXP3HSPA1BIntAct23973223 details
FOXP3IFNGIntAct23543754 details
FOXP3ZEB2IntAct29963231 details