Entity Details

Primary name SMURF2
Entity type gene
Source Source Link

Details

PrimaryID64750
RefseqGene
SymbolSMURF2
NameSMAD specific E3 ubiquitin protein ligase 2
Chromosome17
Location17q23.3-q24.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-01-12
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSMUF2_HUMAN

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000151 ubiquitin ligase complex
GO:0000209 protein polyubiquitination
GO:0004842 ubiquitin-protein transferase activity
GO:0005160 transforming growth factor beta receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0016579 protein deubiquitination
GO:0016607 nuclear speck
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0030579 ubiquitin-dependent SMAD protein catabolic process
GO:0042802 identical protein binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045121 membrane raft
GO:0045732 positive regulation of protein catabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046332 SMAD binding
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061630 ubiquitin protein ligase activity
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901165 positive regulation of trophoblast cell migration

Diseases

Show/Hide Table

Interactions

182 interactions

InteractorPartnerSourcesPublicationsLink
SMURF2RNF11BioGRID, HPRD, I2D, IntAct, MINT14562029 14755250 15231748 20676133 28292929 31985874 details
SMURF2UBBIntAct14755250 17719543 details
SMURF2SMAD2BioGRID, DIP, HPRD, IntAct, MINT11016919 11158580 11389444 15221015 15231748 18729074 19122240 19620243 20937913 22045334 28468752 28881580 details
SMURF2TRAF4BioGRID, HPRD, MINT15231748 23973329 details
SMURF2DAZAP2BioGRID, HPRD, MINT15231748 22070932 details
SMURF2FLNBBioGRID, HPRD, MINT15231748 details
SMURF2TNPO3BioGRID, HPRD, MINT15231748 details
SMURF2SMURF2BioGRID, HPRD, IntAct, MINT15231748 16061177 17719543 17996703 20858899 23973329 25438670 26949039 27086113 28292929 28611047 29463679 29964046 30021006 30587574 31628949 details
SMURF2SMAD7BioGRID, DIP, HPRD, MINT11163210 14722617 15221015 15231748 16061177 16641086 17719543 18448069 20937913 22624557 22773947 22921829 23973329 26435193 26679521 27292644 28292929 29235476 32283253 details
SMURF2SMAD5BioGRID, HPRD, IntAct, MINT15221015 15231748 20484049 28514442 details
SMURF2SPARTBioGRID, HPRD, MINT15231748 19307600 details
SMURF2TFPI2BioGRID, HPRD, MINT15231748 details
SMURF2CANXBioGRID, HPRD, MINT15231748 details
SMURF2CUEDC1BioGRID, HPRD, MINT15231748 details
SMURF2ARHGAP5BioGRID, HPRD, IntAct, MINT15231748 28514442 details
SMURF2TXNIPBioGRID, HPRD, MINT15231748 details
SMURF2DAB2BioGRID, HPRD, MINT15231748 details
SMURF2SMAD6BioGRID, HPRD, MINT15221015 15231748 15761153 24850914 details
SMURF2DGCR2BioGRID, HPRD, MINT15231748 details
SMURF2ABRAXAS2BioGRID, HPRD, MINT15231748 details
SMURF2ACBD3BioGRID, HPRD, MINT15231748 details
SMURF2SF3A2BioGRID, HPRD, MINT15231748 details
SMURF2ACOX3BioGRID, HPRD, MINT15231748 details
SMURF2RNF111BioGRID, HPRD, MINT15231748 details
SMURF2TMEM139BioGRID, HPRD, MINT15231748 details
SMURF2LAPTM5BioGRID, HPRD, MINT15231748 details
SMURF2SNRNP70BioGRID, HPRD, MINT15231748 details
SMURF2SMAD1BioGRID, DIP, HPRD, IntAct, MINT11016919 11158580 14701756 15221015 15231748 20937913 28468752 28514442 32296183 details
SMURF2RHOABioGRID, IntAct17719543 20026602 21402695 details
SMURF2NEBLMINT18157088 details
SMURF2TNNI3MINT18157088 details
SMURF2DESMINT18157088 details
SMURF2TTNMINT18157088 details
SMURF2CCAR1MINT18157088 details
SMURF2FLNCMINT18157088 details
SMURF2FHL2MINT18157088 details
SMURF2GMEB1MINT18157088 details
SMURF2EEF1GMINT18157088 details
SMURF2ECHS1MINT18157088 details
SMURF2GFM1MINT18157088 details
SMURF2UXTMINT18157088 details
SMURF2EIF3EMINT18157088 details
SMURF2DCAF6MINT18157088 details
SMURF2MRPL2MINT18157088 details
SMURF2SQSTM1MINT18157088 details
SMURF2NOMO1MINT18157088 details
SMURF2ATP5F1BMINT18157088 details
SMURF2MYBPC3MINT18157088 details
SMURF2MRPL19MINT18157088 details
SMURF2NDUFA1MINT18157088 details
SMURF2TCAPMINT18157088 details
SMURF2ACTA1MINT18157088 details
SMURF2TNNT1MINT18157088 details
SMURF2NEBMINT18157088 details
SMURF2TNNI2MINT18157088 details
SMURF2MYOZ1MINT18157088 details
SMURF2LMCD1MINT18157088 details
SMURF2MRPL41MINT18157088 details
SMURF2UBCBioGRID, MINT19343052 23644597 23973329 25438670 25723849 28881580 29964046 31628949 details
SMURF2SMAD3BioGRID, HPRD, IntAct, MINT11016919 11158580 11389444 15221015 18729074 19122240 22045334 23973329 28839186 28881580 32296183 details
SMURF2FBXL15BioGRID, MINT21572392 details
SMURF2RTN4IP1BioGRID, IntAct32296183 details
SMURF2NEDD4BioGRID, DIP, IntAct15496141 25438670 28514442 details
SMURF2TTC3BioGRID, UniProt30696809 details
SMURF2AIMP1BioGRID18448069 details
SMURF2UBE2L3BioGRID16061177 17719543 17996703 20858899 25723849 26949039 27182664 29263404 29964046 30587574 31628949 details
SMURF2ID1BioGRID21933340 details
SMURF2ID3BioGRID21933340 details
SMURF2KLF5BioGRID21953463 details
SMURF2EGFRBioGRID21750651 32669362 details
SMURF2RNF20BioGRID22231558 details
SMURF2AXIN1BioGRID20858899 details
SMURF2RUNX2BioGRID21402695 details
SMURF2RLIMBioGRID21945933 details
SMURF2USP15BioGRID22344298 26435193 details
SMURF2UBE2D1BioGRID20858899 24709419 25723849 32669362 details
SMURF2UBE2D3BioGRID20484049 20858899 21402695 23644597 25438670 25723849 28611047 30021006 details
SMURF2MAVSBioGRID24729608 details
SMURF2BTRCBioGRID24709419 details
SMURF2YY1BioGRID24803334 details
SMURF2LATS1BioGRID24107629 details
SMURF2UBE2D2BioGRID25723849 27182664 details
SMURF2PRMT1BioGRID26126536 details
SMURF2AIMP2BioGRID27197155 details
SMURF2FUBP1BioGRID27197155 details
SMURF2XPO1BioGRID27197155 details
SMURF2NEDD8BioGRID28169289 details
SMURF2ITGB1BP1BioGRID28049720 details
SMURF2TOP2ABioGRID28611047 details
SMURF2PDE4BBioGRID29100790 details
SMURF2LMNABioGRID29405587 details
SMURF2CNKSR2BioGRID29534682 details
SMURF2SNCABioGRID30021006 details
SMURF2SIRT1BioGRID32361710 details
SMURF2ZBTB44HPRD15231748 details
SMURF2PARD6AIntAct19379695 details
SMURF2SMURF1BioGRID, IntAct18927080 21897371 27086113 28514442 details
SMURF2TGFBR1BioGRID, HPRD11163210 14722617 21791611 22624557 23973329 25149540 26679521 31746425 details
SMURF2TGFBR2BioGRID11163210 25149540 details
SMURF2SKILBioGRID, HPRD11389444 details
SMURF2TRAF2BioGRID, HPRD18671942 details
SMURF2TNFRSF1BBioGRID18671942 details
SMURF2RUNX3BioGRID, HPRD15138260 details
SMURF2GSK3BBioGRID19481076 details
SMURF2CCM2BioGRID19318350 details
SMURF2HSPB1BioGRID21967197 details
SMURF2EFNB1BioGRID23475958 details
SMURF2SMAD4BioGRID23973329 28468752 details
SMURF2PTCH1BioGRID25092867 details
SMURF2UBE2IBioGRID26679521 details
SMURF2PIAS3BioGRID26679521 details
SMURF2GLIS3BioGRID26147758 details
SMURF2NEDD9BioGRID20825672 details
SMURF2SETD7BioGRID27292644 details
SMURF2SKIBioGRID28468752 details
SMURF2QPRTBioGRID28724915 details
SMURF2UBE2MBioGRID27086113 details
SMURF2PKHD1BioGRID28798345 details
SMURF2FMN2BioGRID29659741 details
SMURF2DVL2BioGRID29659741 details
SMURF2EZH2BioGRID30649914 31948940 details
SMURF2SATB1BioGRID30742943 details
SMURF2BRAFBioGRID31015455 details
SMURF2H2AXBioGRID31533041 details
SMURF2MLXIPLBioGRID31409643 details
SMURF2PARP1BioGRID32167680 details
SMURF2RPS27AHPRD14755250 details
SMURF2ANAPC5HPRD15761153 details
SMURF2ASH2LHPRD15761153 details
SMURF2EPHA1HPRD15761153 details
SMURF2FKBP4HPRD15761153 details
SMURF2GNG2HPRD15761153 details
SMURF2HDGFL3HPRD15761153 details
SMURF2ING2HPRD15761153 details
SMURF2IRF3HPRD15761153 details
SMURF2IRF8HPRD15761153 details
SMURF2NEK6HPRD15761153 details
SMURF2NKIRAS1HPRD15761153 details
SMURF2NRASHPRD15761153 details
SMURF2PPIDHPRD15761153 details
SMURF2RAB13HPRD15761153 details
SMURF2RAB14HPRD15761153 details
SMURF2RAB17HPRD15761153 details
SMURF2RAB22AHPRD15761153 details
SMURF2RAB25HPRD15761153 details
SMURF2RANHPRD15761153 details
SMURF2RASD2HPRD15761153 details
SMURF2RASL12HPRD15761153 details
SMURF2RHODHPRD15761153 details
SMURF2RNF2HPRD15761153 details
SMURF2RRAS2HPRD15761153 details
SMURF2SRSF4HPRD15761153 details
SMURF2SMAP1HPRD15761153 details
SMURF2SOCS6HPRD15761153 details
SMURF2TSSK4HPRD15761153 details
SMURF2RAP1BHPRD17318188 details
SMURF2PRICKLE1HPRD19379695 details
SMURF2PRICKLE2HPRD19379695 details
SMURF2STAMBPBioGRID, IntAct14755250 details
SMURF2LDLRAD4BioGRID, IntAct26186194 28514442 details
SMURF2LINGO2BioGRID, IntAct28514442 details
SMURF2SEMG2BioGRID, IntAct28514442 details
SMURF2MARS2BioGRID, IntAct28514442 details
SMURF2MRPS22BioGRID23973329 details
SMURF2ILF2BioGRID23973329 details
SMURF2YBX1BioGRID23973329 details
SMURF2ACTA2BioGRID23973329 details
SMURF2SMARCA2BioGRID23973329 details
SMURF2ENAHBioGRID23973329 details
SMURF2MRPS23BioGRID23973329 details
SMURF2MRPS7BioGRID23973329 details
SMURF2MYLK2BioGRID23973329 details
SMURF2RBM14BioGRID23973329 details
SMURF2KCTD12BioGRID23973329 details
SMURF2MRPS31BioGRID23973329 details
SMURF2SLC25A5BioGRID23973329 details
SMURF2ESF1BioGRID23973329 details
SMURF2DNAJC10BioGRID23973329 details
SMURF2UBA52BioGRID23973329 details
SMURF2SLC25A6BioGRID23973329 details
SMURF2HNRNPLBioGRID28611215 details
SMURF2VIRMABioGRID29507755 details