Entity Details

Primary name BMPR2
Entity type gene
Source Source Link

Details

PrimaryID659
RefseqGeneNG_009363
SymbolBMPR2
Namebone morphogenetic protein receptor type 2
Chromosome2
Location2q33.1-q33.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-12
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsBMPR2_HUMAN

GO terms

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GOName
GO:0001568 blood vessel development
GO:0001649 osteoblast differentiation
GO:0001707 mesoderm formation
GO:0001893 maternal placenta development
GO:0001935 endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001946 lymphangiogenesis
GO:0001974 blood vessel remodeling
GO:0002063 chondrocyte development
GO:0003085 negative regulation of systemic arterial blood pressure
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003176 aortic valve development
GO:0003177 pulmonary valve development
GO:0003183 mitral valve morphogenesis
GO:0003186 tricuspid valve morphogenesis
GO:0003197 endocardial cushion development
GO:0003252 negative regulation of cell proliferation involved in heart valve morphogenesis
GO:0004674 protein serine/threonine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0005905 clathrin-coated pit
GO:0005912 adherens junction
GO:0006468 protein phosphorylation
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007420 brain development
GO:0009267 cellular response to starvation
GO:0009925 basal plasma membrane
GO:0009952 anterior/posterior pattern specification
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014069 postsynaptic density
GO:0014916 regulation of lung blood pressure
GO:0016324 apical plasma membrane
GO:0019838 growth factor binding
GO:0030166 proteoglycan biosynthetic process
GO:0030308 negative regulation of cell growth
GO:0030425 dendrite
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0036122 BMP binding
GO:0042127 regulation of cell population proliferation
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0044214 spanning component of plasma membrane
GO:0045296 cadherin binding
GO:0045669 positive regulation of osteoblast differentiation
GO:0045778 positive regulation of ossification
GO:0045906 negative regulation of vasoconstriction
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048286 lung alveolus development
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0051148 negative regulation of muscle cell differentiation
GO:0060173 limb development
GO:0060350 endochondral bone morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060413 atrial septum morphogenesis
GO:0060836 lymphatic endothelial cell differentiation
GO:0060840 artery development
GO:0060841 venous blood vessel development
GO:0061036 positive regulation of cartilage development
GO:0061298 retina vasculature development in camera-type eye
GO:0061626 pharyngeal arch artery morphogenesis
GO:0071363 cellular response to growth factor stimulus
GO:0071773 cellular response to BMP stimulus
GO:0072577 endothelial cell apoptotic process
GO:0098821 BMP receptor activity
GO:1902731 negative regulation of chondrocyte proliferation
GO:1905314 semi-lunar valve development
GO:1990782 protein tyrosine kinase binding
GO:2000279 negative regulation of DNA biosynthetic process

Diseases

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Interactions

80 interactions

InteractorPartnerSourcesPublicationsLink
BMPR2GDF5BioGRID, HPRD, MINT19229295 9525338 details
BMPR2MAPK8BioGRID, MINT21900206 details
BMPR2HSCBDIP24606901 details
BMPR2ACVR1BioGRID, IntAct28514442 7791754 7890683 details
BMPR2BMP2BioGRID, DIP, HPRD10712517 10880444 25938661 7791754 details
BMPR2LIMK1BioGRID, HPRD12963706 details
BMPR2TGFBR1BioGRID7791754 7890683 details
BMPR2ACVR1BBioGRID7791754 details
BMPR2TSR1BioGRID7791754 details
BMPR2BMP7BioGRID, HPRD7644468 7791754 details
BMPR2GDF6BioGRID, HPRD9525338 details
BMPR2BMP4BioGRID, HPRD12045205 28126904 7644468 8702914 details
BMPR2GDF9BioGRID, HPRD12135884 details
BMPR2FHL2BioGRID19265191 details
BMPR2TRIB3BioGRID17576816 details
BMPR2PPP1CCBioGRID23080069 details
BMPR2GDF2BioGRID17311849 22718755 details
BMPR2BMP10BioGRID22718755 details
BMPR2TDGF1BioGRID28126904 details
BMPR2INHBBBioGRID28126904 details
BMPR2KITBioGRID16155937 details
BMPR2SMURF1BioGRID31578224 details
BMPR2DYNLT1BioGRID, HPRD14583445 31578224 details
BMPR2PRKG1MINT19424179 details
BMPR2BMPR1ABioGRID, HPRD10712517 7791754 details
BMPR2BMPR1BBioGRID, HPRD10712517 7791754 details
BMPR2BMP6BioGRID, HPRD10504300 11401330 details
BMPR2BMPR2BioGRID, HPRD10712517 details
BMPR2XIAPBioGRID19782107 details
BMPR2FSTBioGRID16198295 details
BMPR2SMAD6BioGRID20663871 details
BMPR2SMAD7BioGRID20663871 details
BMPR2CAV1BioGRID15657086 details
BMPR2ENGBioGRID23967299 details
BMPR2ACVR2ABioGRID23967299 details
BMPR2CDH5BioGRID26598555 details
BMPR2PRKCBHPRD15188402 details
BMPR2MOSHPRD15188402 details
BMPR2TUBB2AHPRD15188402 details
BMPR2MAP3K8HPRD15188402 details
BMPR2LMX1AHPRD15188402 details
BMPR2RABGGTAHPRD15188402 details
BMPR2CTBP1HPRD15188402 details
BMPR2TUBB4AHPRD15188402 details
BMPR2MERTKHPRD15188402 details
BMPR2NBEAHPRD15188402 details
BMPR2HNRNPRHPRD15188402 details
BMPR2FOXL1HPRD15188402 details
BMPR2PMPCAHPRD15188402 details
BMPR2OC90HPRD15188402 details
BMPR2CCDC89HPRD15188402 details
BMPR2SULT1E1HPRD15188402 details
BMPR2ARSAHPRD15188402 details
BMPR2ACTR8HPRD15188402 details
BMPR2NOP56HPRD15188402 details
BMPR2TWF1HPRD15188402 details
BMPR2TRPC1HPRD15188402 details
BMPR2LSM10HPRD15188402 details
BMPR2PDZRN3HPRD15188402 details
BMPR2TOPBP1HPRD15188402 details
BMPR2CES1HPRD15188402 details
BMPR2C4BPAHPRD15188402 details
BMPR2LSP1HPRD15188402 details
BMPR2PYCARDBioGRID, HPIDb24407287 details
BMPR2RUSF1BioGRID, IntAct28514442 details
BMPR2MRAP2BioGRID, IntAct28514442 details
BMPR2RNF11BioGRID, IntAct28514442 details
BMPR2LRRIQ1BioGRID, IntAct28514442 details
BMPR2CD83BioGRID, IntAct28514442 details
BMPR2ARMH4BioGRID, IntAct28514442 details
BMPR2CES3BioGRID15188402 details
BMPR2GCGRBioGRID15188402 details
BMPR2CRYABBioGRID, HPRD15188402 details
BMPR2FRS3BioGRID, HPRD15188402 details
BMPR2CDH1BioGRID25468996 details
BMPR2HRASBioGRID30194290 details
BMPR2NRASBioGRID30194290 details
BMPR2KRASBioGRID30194290 details
BMPR2HNRNPLBioGRID28611215 details
BMPR2VIRMABioGRID29507755 details