Entity Details

Primary name SPG7
Entity type gene
Source Source Link

Details

PrimaryID6687
RefseqGeneNG_008082
SymbolSPG7
NameSPG7 matrix AAA peptidase subunit, paraplegin
Chromosome16
Location16q24.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-06-25
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsSPG7_HUMAN

GO terms

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GOName
GO:0004176 ATP-dependent peptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005757 mitochondrial permeability transition pore complex
GO:0006508 proteolysis
GO:0006851 mitochondrial calcium ion transmembrane transport
GO:0007399 nervous system development
GO:0008053 mitochondrial fusion
GO:0008233 peptidase activity
GO:0008270 zinc ion binding
GO:0034982 mitochondrial protein processing
GO:0042407 cristae formation
GO:0046902 regulation of mitochondrial membrane permeability
GO:0051082 unfolded protein binding
GO:0065003 protein-containing complex assembly
GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death

Diseases

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Interactions

65 interactions

InteractorPartnerSourcesPublicationsLink
SPG7TRIM28BioGRID, HPRD, IntAct16169070 details
SPG7RALYBioGRID, HPRD, IntAct16169070 details
SPG7PLSCR1BioGRID, HPRD, IntAct16189514 details
SPG7KRTAP4-12BioGRID, HPRD, IntAct16189514 details
SPG7MDFIBioGRID, HPRD, IntAct16189514 25416956 32296183 details
SPG7MTUS2BioGRID, IntAct, MINT21516116 25416956 details
SPG7KRTAP5-9BioGRID, MINT21516116 details
SPG7PNMA1BioGRID, IntAct, MINT21516116 25416956 32296183 details
SPG7STAMBPBioGRID, IntAct21988832 details
SPG7SPATS1BioGRID, IntAct21988832 details
SPG7MAPK6BioGRID, MINT21900206 details
SPG7PSTPIP1BioGRID, IntAct25416956 details
SPG7CCNDBP1BioGRID, IntAct25416956 details
SPG7KRTAP10-7BioGRID, IntAct25416956 details
SPG7KRTAP10-9BioGRID, IntAct25416956 details
SPG7KRTAP10-11IntAct25416956 details
SPG7PSME3BioGRID, IntAct25416956 details
SPG7HNRNPKBioGRID, IntAct25416956 32296183 details
SPG7KHDRBS2BioGRID, IntAct25416956 details
SPG7KRT40BioGRID, IntAct25416956 details
SPG7NOTCH2NLABioGRID, IntAct25416956 32296183 details
SPG7RBPMSBioGRID, IntAct25416956 details
SPG7LZTS2BioGRID, IntAct25416956 details
SPG7CYSRT1BioGRID, IntAct32296183 details
SPG7HSF2BPBioGRID, IntAct32296183 details
SPG7BDKRB2BioGRID, MINT28298427 details
SPG7LRIF1BioGRID, HPRD16169070 details
SPG7KRTAP10-3BioGRID25416956 details
SPG7SASH1BioGRID30480076 details
SPG7RIF1IntAct16169070 details
SPG7ELF3IntAct17353931 details
SPG7HTR7bhf-ucl19486527 details
SPG7EMC2BioGRID, IntAct26496610 details
SPG7CERKBioGRID, IntAct26496610 details
SPG7PDK1BioGRID, IntAct26496610 details
SPG7FAM174ABioGRID, IntAct28514442 details
SPG7MAS1BioGRID, IntAct28514442 details
SPG7LPAR4BioGRID, IntAct28514442 details
SPG7CD79ABioGRID, IntAct28514442 details
SPG7APLNRBioGRID, IntAct28514442 details
SPG7SLC2A12BioGRID, IntAct28514442 details
SPG7ISLRBioGRID, IntAct26186194 28514442 details
SPG7CPA5BioGRID, IntAct28514442 details
SPG7AP3S1BioGRID, IntAct28514442 details
SPG7HDAC10BioGRID, IntAct28514442 details
SPG7ITM2ABioGRID, IntAct28514442 details
SPG7LPCAT4BioGRID, IntAct28514442 details
SPG7PHETA1BioGRID, IntAct28514442 details
SPG7NDUFB9BioGRID, IntAct26186194 28514442 details
SPG7MAIP1BioGRID, IntAct27499296 details
SPG7HNRNPRBioGRID22939629 details
SPG7SFXN2BioGRID22939629 details
SPG7SRSF3BioGRID22939629 details
SPG7SLC25A3BioGRID22939629 details
SPG7GPR55BioGRID26186194 details
SPG7SDF4BioGRID26186194 details
SPG7ART3BioGRID26186194 details
SPG7FAF2BioGRID26186194 details
SPG7HTR3CBioGRID26186194 details
SPG7ESR2BioGRID29509190 details
SPG7PLEKHA4BioGRID31091453 details
SPG7ZC3H18BioGRID29298432 details
SPG7KIF14BioGRID31586073 details
SPG7MKRN1BioGRID31640799 details
SPG7DDX58BioGRID32513696 details