Entity Details

Primary name STAT1
Entity type gene
Source Source Link

Details

PrimaryID6772
RefseqGeneNG_008294
SymbolSTAT1
Namesignal transducer and activator of transcription 1
Chromosome2
Location2q32.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-24
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsSTAT1_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002230 positive regulation of defense response to virus by host
GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006952 defense response
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0008015 blood circulation
GO:0010742 macrophage derived foam cell differentiation
GO:0016032 viral process
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0019899 enzyme binding
GO:0030424 axon
GO:0030425 dendrite
GO:0032727 positive regulation of interferon-alpha production
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034097 response to cytokine
GO:0035035 histone acetyltransferase binding
GO:0035456 response to interferon-beta
GO:0035458 cellular response to interferon-beta
GO:0038113 interleukin-9-mediated signaling pathway
GO:0038114 interleukin-21-mediated signaling pathway
GO:0042127 regulation of cell population proliferation
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043434 response to peptide hormone
GO:0044389 ubiquitin-like protein ligase binding
GO:0045296 cadherin binding
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046725 negative regulation by virus of viral protein levels in host cell
GO:0048471 perinuclear region of cytoplasm
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051591 response to cAMP
GO:0051607 defense response to virus
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0061326 renal tubule development
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070106 interleukin-27-mediated signaling pathway
GO:0070757 interleukin-35-mediated signaling pathway
GO:0071346 cellular response to interferon-gamma
GO:0072136 metanephric mesenchymal cell proliferation involved in metanephros development
GO:0072162 metanephric mesenchymal cell differentiation
GO:0072308 negative regulation of metanephric nephron tubule epithelial cell differentiation
GO:1990841 promoter-specific chromatin binding

Diseases

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Interactions

288 interactions

InteractorPartnerSourcesPublicationsLink
STAT1LMO2BioGRID, HPRD, IntAct16189514 25416956 details
STAT1EIF1ADBioGRID, HPRD, IntAct16189514 25416956 details
STAT1ERBB2BioGRID, IntAct, MINT16273093 25241761 details
STAT1NMIBioGRID, HPRD, IntAct9989503 details
STAT1STAT2BioGRID, HPIDb, HPRD, IntAct, MINT10446176 10490982 12048190 15825084 17923090 24065129 26966684 28514442 31836668 8605877 8621447 9724754 details
STAT1IRF9BioGRID, HPRD, IntAct, MINT17923090 24065129 8943351 details
STAT1E2F1BioGRID, IntAct20195357 details
STAT1IFNGR1BioGRID, HPRD, MINT10848598 15494521 15780933 21689637 7514165 8156998 8662591 details
STAT1EGFRBioGRID, HPRD, IntAct, MINT10358079 10918587 11294897 11839738 12070153 12637327 12817007 15284024 15322115 23956138 24658140 24797263 25402006 31980649 7543024 7657660 7690989 details
STAT1IFNAR2BioGRID, HPRD, MINT11301323 29997210 32123171 9121453 details
STAT1STAT1BioGRID, DIP, HPRD, MINT12873986 14704793 15284440 15780933 16007122 18591661 21914072 32814877 8605877 8621447 9630226 details
STAT1IL6STMINT8662591 details
STAT1STAT3BioGRID, DIP, HPRD, IntAct, MINT11594781 11722592 12070153 16007122 25241761 25609649 26966684 28514442 31462771 8662591 details
STAT1ACTN4BioGRID, IntAct20936779 details
STAT1DCTN1BioGRID, IntAct20936779 details
STAT1GFAPBioGRID, IntAct20936779 details
STAT1HSP90AB1BioGRID, IntAct20936779 details
STAT1SHANK1BioGRID, IntAct20936779 details
STAT1SPTAN1BioGRID, IntAct, MINT20936779 26966684 details
STAT1SPTBN1BioGRID, IntAct20936779 details
STAT1DDB1BioGRID, IntAct21988832 details
STAT1HADHBioGRID, IntAct21988832 details
STAT1HLA-BBioGRID, IntAct21988832 details
STAT1ND4LBioGRID, IntAct21988832 details
STAT1PORBioGRID, IntAct21988832 details
STAT1RXRABioGRID, IntAct21988832 details
STAT1NOMO1BioGRID, IntAct21988832 details
STAT1NOMO2BioGRID, IntAct21988832 details
STAT1MAVSBioGRID, IntAct21903422 details
STAT1KITBioGRID, HPRD, IntAct25241761 9355737 details
STAT1PTK2BioGRID, IntAct11278462 20576130 25241761 details
STAT1PIAS1BioGRID, HPRD, IntAct10805787 11257227 12171910 12855578 17371985 18566411 25241761 9724754 details
STAT1JAK2BioGRID, HPRD, MINT10918587 11152457 11294897 11839738 12637327 12817007 14978237 15284024 15322115 19834108 20353823 24255956 7543024 7657660 7690989 details
STAT1SPTBBioGRID, IntAct25814554 details
STAT1IRF1BioGRID, HPRD, IntAct, NTNU10764778 16512786 17525742 19124747 8810328 details
STAT1OTUD4BioGRID, IntAct25416956 details
STAT1KPNA1BioGRID, HPRD, MINT10964507 12048190 17596301 26966684 details
STAT1JAK1BioGRID, HPRD, IntAct10918587 10982844 11294897 11722592 11839738 12637327 12817007 14978237 15284024 15322115 32123171 32814877 32953130 7543024 7657660 7690989 details
STAT1LZTR1BioGRID, IntAct20211142 details
STAT1FANCCBioGRID, HPRD10848598 11520787 14499622 details
STAT1RACK1BioGRID, HPRD11301323 12960323 details
STAT1TYK2BioGRID, HPRD10918587 11294897 11839738 12637327 12817007 12960323 15322115 7543024 7657660 7690989 details
STAT1IL27RABioGRID, HPRD12734330 details
STAT1CREBBPBioGRID, HPRD10848577 15695802 15894584 16481475 19915063 25451029 25733689 8986769 9037008 details
STAT1EIF2AK2BioGRID, HPRD11278865 9135145 details
STAT1IL2RBBioGRID, HPRD10602027 details
STAT1MCM5BioGRID, HPRD11248027 9843502 details
STAT1VDRBioGRID, HPRD11909970 details
STAT1TRADDBioGRID, HPRD10848577 details
STAT1PRKCDBioGRID, HPRD11839738 11972023 12637327 12807916 12817007 14963018 15322115 19553685 7543024 7690989 9355737 details
STAT1ELP2BioGRID, HPRD10954736 details
STAT1GTF2IBioGRID, HPRD9584171 details
STAT1BRCA1BioGRID, HPRD10792030 details
STAT1ATF3BioGRID19647793 details
STAT1DOT1LBioGRID22002246 details
STAT1UBE2IBioGRID, HPRD12356736 14517261 details
STAT1PRMT1BioGRID, HPRD11257227 12171910 details
STAT1PRMT3BioGRID11257227 details
STAT1PIK3CABioGRID11438544 details
STAT1XPO1BioGRID, HPRD22833565 26673895 9205132 details
STAT1CASP3BioGRID18723680 details
STAT1CASP7BioGRID18723680 details
STAT1STAT4BioGRID21826217 details
STAT1PTPN11BioGRID, HPRD12270932 27229929 details
STAT1HSPA8BioGRID19299420 27684187 details
STAT1DUSP2BioGRID12270932 details
STAT1SIRPABioGRID19299420 details
STAT1FTH1BioGRID19299420 details
STAT1DDX6BioGRID19299420 details
STAT1CDC42BioGRID31478661 details
STAT1PTP4A3IntAct17353931 details
STAT1UBE2FIntAct17353931 details
STAT1GSTK1IntAct17353931 details
STAT1IFNAR1MINT9121453 details
STAT1DNAJA3IntAct21106534 details
STAT1PDGFRABioGRID, HPRD, IntAct25241761 9484840 details
STAT1MTORBioGRID, IntAct12807916 19553685 25241761 details
STAT1FOSBioGRID, HPRD, IntAct12788789 25241761 details
STAT1RELABioGRID, HPRD, IntAct16481475 25241761 details
STAT1STAT5ABioGRID, HPRD, IntAct10358045 25241761 details
STAT1CNOT7MINT23386060 details
STAT1PDGFRBHPRD, IntAct23397142 8549654 9484840 details
STAT1DDX58IntAct24360797 details
STAT1PRKCEBioGRID, IntAct20353823 24825907 details
STAT1KDM3ADIP25535969 details
STAT1KPNA6HPRD, MINT16298512 26966684 details
STAT1EP300BioGRID, HPRD10464260 11134049 11923478 12403783 15824515 18566411 19915063 26479788 26504087 8986769 9843502 details
STAT1SRCBioGRID, HPRD10358079 14978237 9344858 details
STAT1HSF1BioGRID, HPRD9880553 details
STAT1TNFRSF1ABioGRID, HPRD10848577 details
STAT1JUNBioGRID, HPRD10490649 details
STAT1RNF11BioGRID19131965 details
STAT1PTPN2BioGRID, HPRD12138178 12171910 14600148 19171783 details
STAT1MBD1BioGRID19074829 details
STAT1BCL3BioGRID16306601 details
STAT1SMARCA4BioGRID16195385 20353823 21079652 details
STAT1TRIM28BioGRID18037959 18381204 details
STAT1CTNNBL1BioGRID21385873 details
STAT1SMARCA2BioGRID21079652 details
STAT1SMURF1BioGRID22474288 details
STAT1PSMC3BioGRID19853614 details
STAT1H3C14BioGRID21689637 details
STAT1HDAC4BioGRID21571862 details
STAT1ISG15BioGRID16009940 33024031 details
STAT1IRAK1BioGRID12856330 details
STAT1NFKBIABioGRID16481475 details
STAT1HDAC1BioGRID16481475 details
STAT1HDAC3BioGRID16481475 details
STAT1IGBP1BioGRID19553685 details
STAT1MLST8BioGRID19553685 details
STAT1PTPABioGRID19553685 details
STAT1RPS6KB1BioGRID19553685 details
STAT1USP13BioGRID23940278 details
STAT1DTX3LBioGRID24886089 26479788 details
STAT1GNB2BioGRID23326349 details
STAT1PMLBioGRID25733689 25812002 details
STAT1PARP9BioGRID23487038 26479788 details
STAT1H2BC11BioGRID26479788 details
STAT1PPARABioGRID26504087 details
STAT1PPARDBioGRID26504087 details
STAT1PPARGBioGRID26504087 details
STAT1FANCEBioGRID26277624 details
STAT1U2AF2BioGRID26641092 details
STAT1ITGAVBioGRID23640055 details
STAT1HSP90B1BioGRID18662321 details
STAT1TNK2BioGRID28739485 details
STAT1USP2BioGRID27434509 details
STAT1NR1H3BioGRID27485016 details
STAT1NR1H2BioGRID27485016 details
STAT1MAGEA3BioGRID30588194 details
STAT1RNF31BioGRID32123171 details
STAT1OTULINBioGRID32123171 details
STAT1RNF220BioGRID32814877 details
STAT1ATG5BioGRID33024031 details
STAT1TNFRSF1BHPRD10848577 details
STAT1BMXHPRD9373245 details
STAT1IL2RGHPRD11418623 details
STAT1CSE1LHPRD11927559 details
STAT1RPS6KA5HPRD14963018 details
STAT1ZNF467HPRD12426389 details
STAT1MAPK14HPRD11226159 details
STAT1DUSP3HPRD11238845 details
STAT1CSF2RBHPRD8631962 details
STAT1MCM3HPRD9843502 details
STAT1CAMK2DHPRD11972023 details
STAT1RAC1HPRD15494521 details
STAT1CXCR4HPRD10506573 details
STAT1KDRHPRD10961983 details
STAT1FLT1HPRD15703780 details
STAT1CCR1HPRD14674010 details
STAT1CCR5HPRD14674010 details
STAT1FYNHPRD9804857 details
STAT1IRF2HPRD15778351 details
STAT1AKT1HPRD15284024 details
STAT1FADDHPRD10848577 details
STAT1STAT5BHPRD10358045 details
STAT1SYKHPRD15467722 details
STAT1SUMO4HPRD16236267 details
STAT1FGFR3HPRD10918587 11294897 11839738 12637327 12817007 15322115 7543024 7657660 7690989 details
STAT1FGFR4HPRD10918587 11294897 11839738 12637327 12817007 15322115 7543024 7657660 7690989 details
STAT1ADRA1BHPRD10652206 details
STAT1LCKHPRD10918587 11294897 11839738 12637327 12817007 15322115 7543024 7657660 7690989 details
STAT1MDKHPRD9452495 details
STAT1BPIFB3BioGRID, IntAct17353931 details
STAT1ARRB2BioGRID, IntAct17620599 details
STAT1STK4IntAct23386615 details
STAT1RARAIntAct25303530 details
STAT1GATA3IntAct25303530 details
STAT1ESR1BioGRID, IntAct25303530 31527615 details
STAT1FOXA3BioGRID, MINT25609649 details
STAT1HSCBBioGRID, IntAct28380382 details
STAT1DOCK4BioGRID, IntAct28514442 details
STAT1INAMINT26966684 details
STAT1PLECMINT26966684 details
STAT1DESMINT26966684 details
STAT1PTBP2MINT26966684 details
STAT1CAPRIN1MINT26966684 details
STAT1PABPC3MINT26966684 details
STAT1STMN1MINT26966684 details
STAT1LDHBMINT26966684 details
STAT1TBCAMINT26966684 details
STAT1ACTG1MINT26966684 details
STAT1FARSBMINT26966684 details
STAT1HSD17B4MINT26966684 details
STAT1GLO1MINT26966684 details
STAT1UQCRC1MINT26966684 details
STAT1PYGLMINT26966684 details
STAT1CANXMINT26966684 details
STAT1ERP44MINT26966684 details
STAT1PGDMINT26966684 details
STAT1PFKLMINT26966684 details
STAT1UCHL1MINT26966684 details
STAT1UBE2MMINT26966684 details
STAT1NDUFS3MINT26966684 details
STAT1ETFBMINT26966684 details
STAT1CHCHD3MINT26966684 details
STAT1RRP1BIntAct20926688 details
STAT1DDR1MINT22057045 details
STAT1NUDCD1MINT29021621 details
STAT1TNFAIP3BioGRID, IntAct30561431 details
STAT1LRRK2IntAct31046837 details
STAT1GRNUniProt26370502 details
STAT1PRKCBBioGRID, IntAct31980649 details
STAT1TEX101BioGRID, UniProt30097533 details
STAT1ZDHHC5UniProt31402609 details
STAT1NMD3BioGRID22939629 details
STAT1NSFBioGRID22939629 details
STAT1PHGDHBioGRID22939629 details
STAT1VCPBioGRID23383273 details
STAT1APEHBioGRID22863883 details
STAT1CAND1BioGRID22863883 details
STAT1CTTNBioGRID22863883 details
STAT1GSPT2BioGRID22863883 details
STAT1HIRIP3BioGRID22863883 details
STAT1HSPA4LBioGRID22863883 details
STAT1IDEBioGRID22863883 details
STAT1JMJD6BioGRID22863883 details
STAT1KARS1BioGRID22863883 details
STAT1NAA10BioGRID22863883 details
STAT1SARS1BioGRID22863883 details
STAT1SHMT2BioGRID22863883 details
STAT1SNX2BioGRID22863883 details
STAT1SNX6BioGRID22863883 details
STAT1ATG7BioGRID22863883 details
STAT1ATP6V1C1BioGRID22863883 details
STAT1NAA15BioGRID22863883 details
STAT1PAWRBioGRID22863883 details
STAT1RTF1BioGRID22863883 details
STAT1SHMT1BioGRID22863883 details
STAT1SNX1BioGRID22863883 details
STAT1TSNAXBioGRID22863883 details
STAT1VPS29BioGRID22863883 details
STAT1YAP1BioGRID22863883 27684187 details
STAT1TBCDBioGRID22863883 details
STAT1VPS26ABioGRID22863883 details
STAT1HUWE1BioGRID25147182 details
STAT1CCDC8BioGRID24711643 details
STAT1HLA-DRB5BioGRID26186194 details
STAT1SPACA1BioGRID26186194 details
STAT1TEX264BioGRID26186194 details
STAT1AARS1BioGRID26344197 details
STAT1AHSA1BioGRID26344197 details
STAT1CIAPIN1BioGRID26344197 details
STAT1PAK2BioGRID26344197 details
STAT1NTRK1BioGRID25921289 details
STAT1CDH1BioGRID25468996 details
STAT1G3BP1BioGRID26777405 details
STAT1TESBioGRID28378594 details
STAT1GSK3ABioGRID27684187 details
STAT1TGFB1BioGRID27684187 details
STAT1CSNK1A1BioGRID27684187 details
STAT1CTNNB1BioGRID27684187 details
STAT1YAF2BioGRID27684187 details
STAT1RNF4BioGRID29180619 details
STAT1ESR2BioGRID29509190 details
STAT1TRIM11BioGRID29581427 details
STAT1FBXW7BioGRID29346117 details
STAT1MYCBioGRID29467282 details
STAT1CDK9BioGRID26209609 details
STAT1DCAF13BioGRID29499938 details
STAT1ATG16L1BioGRID30196744 details
STAT1ACTC1BioGRID30890647 details
STAT1TGFBR2BioGRID28443643 details
STAT1NR2C2BioGRID30463901 details
STAT1CUL4BBioGRID30945288 details
STAT1STAU1BioGRID30948266 details
STAT1WWP2BioGRID31048545 details
STAT1PLEKHA4BioGRID31091453 details
STAT1BRD4BioGRID32416067 details
STAT1UNKBioGRID32123171 details
STAT1DNAJC6BioGRID32123171 details
STAT1SLITRK5BioGRID32123171 details
STAT1AGAP3BioGRID32123171 details
STAT1PRKD3BioGRID32123171 details
STAT1MAP7D1BioGRID32123171 details
STAT1PRMT9BioGRID32123171 details
STAT1COPS5BioGRID31950832 details
STAT1SMARCB1IntAct18267069 details
STAT1IL18BPIntAct19046253 details
STAT1EGLN3IntAct19574556 details
STAT1DUOX2IntAct21321110 details
STAT1MUC4IntAct17525742 details
STAT1TFF1IntAct25303530 details
STAT1GREB1IntAct25303530 details
STAT1CX3CL1IntAct25040843 details
STAT1NOX5IntAct22348975 details
STAT1FOXP3IntAct19124747 details
STAT1TNFSF13BIntAct23271704 details