Entity Details

Primary name CSPG2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13611
EntryNameCSPG2_HUMAN
FullNameVersican core protein
TaxID9606
Evidenceevidence at protein level
Length3396
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesVCAN

GO terms

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GOName
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0001750 photoreceptor outer segment
GO:0005509 calcium ion binding
GO:0005539 glycosaminoglycan binding
GO:0005540 hyaluronic acid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0007155 cell adhesion
GO:0007275 multicellular organism development
GO:0007417 central nervous system development
GO:0008037 cell recognition
GO:0008347 glial cell migration
GO:0016020 membrane
GO:0030021 extracellular matrix structural constituent conferring compression resistance
GO:0030198 extracellular matrix organization
GO:0030206 chondroitin sulfate biosynthetic process
GO:0030207 chondroitin sulfate catabolic process
GO:0030208 dermatan sulfate biosynthetic process
GO:0030246 carbohydrate binding
GO:0031012 extracellular matrix
GO:0033165 interphotoreceptor matrix
GO:0043202 lysosomal lumen
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0062023 collagen-containing extracellular matrix

Subcellular Location

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Subcellular Location
Cell projection
Secreted

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000436 Sushi/SCR/CCP domainDomainDomain
IPR000538 Link domainDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001304 C-type lectin-likeDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016186 C-type lectin-like/link domain superfamilyFamilyHomologous superfamily
IPR016187 C-type lectin foldFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR018378 C-type lectin, conserved siteSiteConserved site
IPR033987 Aggrecan/versican, C-type lectin-like domainDomainDomain
IPR035976 Sushi/SCR/CCP superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
143200 OMIMWagner vitreoretinopathy (WGVRP)A rare vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. The disease is caused by variants affecting the gene represented in this entry. The pathological mechanism involves a quantitative imbalance of the normally occurring splice variants (PubMed:22739342).

Drugs

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DrugNameSourceType
DB08818 Hyaluronic acidDrugbanksmall molecule