Entity Details

Primary name HLAB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01889
EntryNameHLAB_HUMAN
FullNameHLA class I histocompatibility antigen, B alpha chain
TaxID9606
Evidenceevidence at protein level
Length362
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesHLA-B

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002250 adaptive immune response
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
GO:0002667 regulation of T cell anergy
GO:0005102 signaling receptor binding
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006952 defense response
GO:0006955 immune response
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0016032 viral process
GO:0016045 detection of bacterium
GO:0030667 secretory granule membrane
GO:0030670 phagocytic vesicle membrane
GO:0031901 early endosome membrane
GO:0032655 regulation of interleukin-12 production
GO:0032675 regulation of interleukin-6 production
GO:0042270 protection from natural killer cell mediated cytotoxicity
GO:0042605 peptide antigen binding
GO:0042612 MHC class I protein complex
GO:0043312 neutrophil degranulation
GO:0046977 TAP binding
GO:0050776 regulation of immune response
GO:0051087 chaperone binding
GO:0055038 recycling endosome membrane
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0070062 extracellular exosome
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:2001198 regulation of dendritic cell differentiation

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001039 MHC class I alpha chain, alpha1 alpha2 domainsDomainDomain
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR010579 MHC class I, alpha chain, C-terminalDomainDomain
IPR011161 MHC class I-like antigen recognition-likeDomainDomain
IPR011162 MHC classes I/II-like antigen recognition proteinFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR037055 MHC class I-like antigen recognition-like superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
106300 OMIMSpondyloarthropathy 1 (SPDA1)A chronic rheumatic disease with multifactorial inheritance. It includes a spectrum of related disorders comprising ankylosing spondylitis, a subset of psoriatic arthritis, reactive arthritis (e.g. Reiter syndrome), arthritis associated with inflammatory bowel disease and undifferentiated spondyloarthropathy. These disorders may occur simultaneously or sequentially in the same patient, probably representing various phenotypic expressions of the same disease. Ankylosing spondylitis is the form of rheumatoid arthritis affecting the spine and is considered the prototype of seronegative spondyloarthropathies. It produces pain and stiffness as a result of inflammation of the sacroiliac, intervertebral, and costovertebral joints. Disease susceptibility is associated with variants affecting the gene represented in this entry. A restricted number of HLA-B*27 subtypes can be associated with ankylosing spondylitis and other B*27-related diseases, and an elevated frequency of the B*27:02 allele in ankylosing spondylitis patients is identified. The allele B*27:07 seems to have a protective role in some populations because it was found only in the healthy controls.
608579 OMIMStevens-Johnson syndrome (SJS)A rare blistering mucocutaneous disease that share clinical and histopathologic features with toxic epidermal necrolysis. Both disorders are characterized by high fever, malaise, and a rapidly developing blistering exanthema of macules and target-like lesions accompanied by mucosal involvement. Stevens-Johnson syndrome is a milder disease characterized by destruction and detachment of the skin epithelium and mucous membranes involving less than 10% of the body surface area. Ocular symptoms include ulcerative conjunctivitis, keratitis, iritis, uveitis and sometimes blindness. It can be caused by a severe adverse reaction to particular types of medication, although Mycoplasma infections may induce some cases. Disease susceptibility is associated with variants affecting the gene represented in this entry. Increased susceptibility to Stevens-Johnson syndrome is conferred by allele B*15:02.

Drugs

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DrugNameSourceType
DB01048 AbacavirDrugbanksmall molecule
DB04464 N-FormylmethionineDrugbanksmall molecule
DB11294 Coccidioides immitis spheruleDrugbankbiotech

Interactions

278 interactions

InteractorPartnerSourcesPublicationsLink
HLAB_HUMANB2MG_HUMANBioGRID, HPRD, IntAct, MINT10975842 11738047 11823531 12244049 17057332 2450918 26186194 27649529 28514442 8624811 8624812 details
HLAB_HUMANMCAF1_HUMANHPRD, MINT15231748 details
HLAB_HUMANARHG4_HUMANBioGRID, IntAct20936779 details
HLAB_HUMANSTAT1_HUMANBioGRID, IntAct21988832 details
HLAB_HUMANKI2S4_HUMANIntAct19858347 details
HLAB_HUMANKI2L3_HUMANIntAct19858347 details
HLAB_HUMANKI3L2_HUMANIntAct24018270 details
HLAB_HUMANKI2L1_HUMANIntAct28546555 details
HLAB_HUMANNAL12_HUMANI2D32226298 details
HLAB_HUMANLIRB1_HUMANBioGRID, HPRD12853576 details
HLAB_HUMANCD8A_HUMANBioGRID, HPRD10809759 9331948 details
HLAB_HUMANTRIB3_HUMANBioGRID18276110 details
HLAB_HUMANHLAC_HUMANBioGRID, IntAct17353931 26186194 28514442 details
HLAB_HUMANPEBP1_HUMANIntAct17353931 details
HLAB_HUMANEIF3I_HUMANIntAct17353931 details
HLAB_HUMANRAGP1_HUMANIntAct17353931 details
HLAB_HUMANCH10_HUMANIntAct17353931 details
HLAB_HUMAN6PGD_HUMANIntAct17353931 details
HLAB_HUMANCYBP_HUMANIntAct17353931 details
HLAB_HUMANDLRB1_HUMANIntAct17353931 details
HLAB_HUMANTHIO_HUMANIntAct17353931 details
HLAB_HUMANQCR2_HUMANIntAct17353931 details
HLAB_HUMANCLPP_HUMANIntAct17353931 details
HLAB_HUMANSTRAP_HUMANIntAct17353931 details
HLAB_HUMANMTPN_HUMANIntAct17353931 details
HLAB_HUMANTPP2_HUMANIntAct17353931 details
HLAB_HUMANPPIB_HUMANIntAct17353931 details
HLAB_HUMANARF6_HUMANIntAct17353931 details
HLAB_HUMANDCTP1_HUMANIntAct17353931 details
HLAB_HUMANOAT_HUMANIntAct17353931 details
HLAB_HUMANACTZ_HUMANIntAct17353931 details
HLAB_HUMANMCM3_HUMANIntAct17353931 details
HLAB_HUMANHLAA_HUMANBioGRID, IntAct17353931 26186194 28514442 details
HLAB_HUMANPSB3_HUMANIntAct17353931 details
HLAB_HUMANGANAB_HUMANIntAct17353931 details
HLAB_HUMANVATA_HUMANIntAct17353931 details
HLAB_HUMANZNRD2_HUMANIntAct17353931 details
HLAB_HUMANCDN2A_HUMANIntAct17353931 details
HLAB_HUMANCYB5B_HUMANIntAct17353931 details
HLAB_HUMANRS14_HUMANIntAct17353931 details
HLAB_HUMANAATM_HUMANIntAct17353931 details
HLAB_HUMANRAB5C_HUMANIntAct17353931 details
HLAB_HUMANTHIC_HUMANIntAct17353931 details
HLAB_HUMANPAIRB_HUMANIntAct17353931 details
HLAB_HUMANVPS35_HUMANIntAct17353931 details
HLAB_HUMANMCM6_HUMANIntAct17353931 details
HLAB_HUMANSEC63_HUMANIntAct17353931 details
HLAB_HUMANPP2AB_HUMANIntAct17353931 details
HLAB_HUMANTAGL2_HUMANIntAct17353931 details
HLAB_HUMANSDHA_HUMANBioGRID, IntAct17353931 29128334 details
HLAB_HUMANMIF_HUMANIntAct17353931 details
HLAB_HUMANGLRX5_HUMANIntAct17353931 details
HLAB_HUMANIF2B1_HUMANIntAct17353931 details
HLAB_HUMANAAAT_HUMANIntAct17353931 details
HLAB_HUMANKCD12_HUMANIntAct17353931 details
HLAB_HUMANRUVB2_HUMANIntAct17353931 details
HLAB_HUMANNAA15_HUMANIntAct17353931 details
HLAB_HUMANRL32_HUMANIntAct17353931 details
HLAB_HUMANCD81_HUMANIntAct17353931 details
HLAB_HUMANCAZA1_HUMANIntAct17353931 details
HLAB_HUMANLPPRC_HUMANIntAct17353931 details
HLAB_HUMANTADBP_HUMANIntAct17353931 details
HLAB_HUMANFSCN1_HUMANIntAct17353931 details
HLAB_HUMANFKBP3_HUMANIntAct17353931 details
HLAB_HUMANWDR48_HUMANIntAct17353931 details
HLAB_HUMANPSB6_HUMANIntAct17353931 details
HLAB_HUMANAIMP1_HUMANIntAct17353931 details
HLAB_HUMANRU2B_HUMANIntAct17353931 details
HLAB_HUMANAHSA1_HUMANIntAct17353931 details
HLAB_HUMANVAPA_HUMANIntAct17353931 details
HLAB_HUMANDAD1_HUMANIntAct17353931 details
HLAB_HUMANEIF3D_HUMANIntAct17353931 details
HLAB_HUMANPGRC1_HUMANIntAct17353931 details
HLAB_HUMANSMAP_HUMANIntAct17353931 details
HLAB_HUMANCAPR1_HUMANIntAct17353931 details
HLAB_HUMANRAB21_HUMANIntAct17353931 details
HLAB_HUMANSMC2_HUMANIntAct17353931 details
HLAB_HUMANPDIA4_HUMANIntAct17353931 details
HLAB_HUMANHBA_HUMANIntAct17353931 details
HLAB_HUMANSEPT2_HUMANIntAct17353931 details
HLAB_HUMANRL38_HUMANIntAct17353931 details
HLAB_HUMANAPEX1_HUMANIntAct17353931 details
HLAB_HUMANEIF3F_HUMANIntAct17353931 details
HLAB_HUMANUBE2K_HUMANIntAct17353931 details
HLAB_HUMANAIFM1_HUMANIntAct17353931 details
HLAB_HUMANARL1_HUMANIntAct17353931 details
HLAB_HUMANNASP_HUMANIntAct17353931 details
HLAB_HUMANFHL1_HUMANIntAct17353931 details
HLAB_HUMANEF1B_HUMANIntAct17353931 details
HLAB_HUMANPSB4_HUMANIntAct17353931 details
HLAB_HUMANDHX9_HUMANIntAct17353931 details
HLAB_HUMANSTMN1_HUMANIntAct17353931 details
HLAB_HUMANLAGE3_HUMANIntAct17353931 details
HLAB_HUMANRL3_HUMANIntAct17353931 details
HLAB_HUMANPSMD6_HUMANIntAct17353931 details
HLAB_HUMANSFXN1_HUMANIntAct17353931 details
HLAB_HUMANCSDE1_HUMANIntAct17353931 details
HLAB_HUMANPSME3_HUMANIntAct17353931 details
HLAB_HUMANRBBP4_HUMANIntAct17353931 details
HLAB_HUMANDRG1_HUMANIntAct17353931 details
HLAB_HUMANTHIL_HUMANIntAct17353931 details
HLAB_HUMANEF1D_HUMANIntAct17353931 details
HLAB_HUMANPSA1_HUMANIntAct17353931 details
HLAB_HUMANNUDC_HUMANIntAct17353931 details
HLAB_HUMANRL29_HUMANIntAct17353931 details
HLAB_HUMANPSA6_HUMANIntAct17353931 details
HLAB_HUMANSRP68_HUMANIntAct17353931 details
HLAB_HUMANPSD13_HUMANIntAct17353931 details
HLAB_HUMANGLYM_HUMANIntAct17353931 details
HLAB_HUMANTOM40_HUMANIntAct17353931 details
HLAB_HUMANGDIA_HUMANIntAct17353931 details
HLAB_HUMANRAB2A_HUMANIntAct17353931 details
HLAB_HUMANGRPE1_HUMANIntAct17353931 details
HLAB_HUMANTKT_HUMANIntAct17353931 details
HLAB_HUMANPA2G4_HUMANIntAct17353931 details
HLAB_HUMANPSMD3_HUMANIntAct17353931 details
HLAB_HUMANPFKAP_HUMANIntAct17353931 details
HLAB_HUMANNACP4_HUMANIntAct17353931 details
HLAB_HUMANSNX3_HUMANIntAct17353931 details
HLAB_HUMANNUDT5_HUMANIntAct17353931 details
HLAB_HUMANS10AB_HUMANIntAct17353931 details
HLAB_HUMANC1TC_HUMANIntAct17353931 details
HLAB_HUMANTR112_HUMANIntAct17353931 details
HLAB_HUMANSLIRP_HUMANIntAct17353931 details
HLAB_HUMANMP2K1_HUMANIntAct17353931 details
HLAB_HUMANSND1_HUMANIntAct17353931 details
HLAB_HUMANANXA2_HUMANIntAct17353931 details
HLAB_HUMANEFTU_HUMANIntAct17353931 details
HLAB_HUMANHPRT_HUMANIntAct17353931 details
HLAB_HUMANPSB1_HUMANIntAct17353931 details
HLAB_HUMANRAB7A_HUMANIntAct17353931 details
HLAB_HUMANIF2G_HUMANIntAct17353931 details
HLAB_HUMANSYRC_HUMANIntAct17353931 details
HLAB_HUMANADPPT_HUMANIntAct17353931 details
HLAB_HUMANPSA7_HUMANIntAct17353931 details
HLAB_HUMANAATC_HUMANIntAct17353931 details
HLAB_HUMANCISY_HUMANIntAct17353931 details
HLAB_HUMANDDX21_HUMANIntAct17353931 details
HLAB_HUMANSBDS_HUMANIntAct17353931 details
HLAB_HUMANLMNB1_HUMANIntAct17353931 details
HLAB_HUMANPRS4_HUMANIntAct17353931 details
HLAB_HUMANDBLOH_HUMANIntAct17353931 details
HLAB_HUMANDYL1_HUMANIntAct17353931 details
HLAB_HUMANPDCD5_HUMANIntAct17353931 details
HLAB_HUMANSRP14_HUMANIntAct17353931 details
HLAB_HUMANRM40_HUMANIntAct17353931 details
HLAB_HUMANSAE2_HUMANIntAct17353931 details
HLAB_HUMANCSN3_HUMANIntAct17353931 details
HLAB_HUMANTXD17_HUMANIntAct17353931 details
HLAB_HUMANPSMD4_HUMANIntAct17353931 details
HLAB_HUMANSODM_HUMANIntAct17353931 details
HLAB_HUMANCALM2_HUMANIntAct17353931 details
HLAB_HUMANRPN1_HUMANIntAct17353931 details
HLAB_HUMANAL9A1_HUMANIntAct17353931 details
HLAB_HUMANCOX2_HUMANIntAct17353931 details
HLAB_HUMANSC23A_HUMANIntAct17353931 details
HLAB_HUMANCLIC1_HUMANIntAct17353931 details
HLAB_HUMANCYTB_HUMANIntAct17353931 details
HLAB_HUMANHS74L_HUMANIntAct17353931 details
HLAB_HUMANTSN_HUMANIntAct17353931 details
HLAB_HUMANSET_HUMANIntAct17353931 details
HLAB_HUMANDOPD_HUMANIntAct17353931 details
HLAB_HUMANHNRPQ_HUMANIntAct17353931 details
HLAB_HUMANUB2D3_HUMANIntAct17353931 details
HLAB_HUMANUBP14_HUMANIntAct17353931 details
HLAB_HUMANRANG_HUMANIntAct17353931 details
HLAB_HUMANTTL12_HUMANIntAct17353931 details
HLAB_HUMANECHM_HUMANIntAct17353931 details
HLAB_HUMANHINT1_HUMANIntAct17353931 details
HLAB_HUMANTIM13_HUMANIntAct17353931 details
HLAB_HUMANIMA4_HUMANIntAct17353931 details
HLAB_HUMANVMA21_HUMANIntAct17353931 details
HLAB_HUMANRAB1B_HUMANIntAct17353931 details
HLAB_HUMANBTF3_HUMANIntAct17353931 details
HLAB_HUMANRCC2_HUMANIntAct17353931 details
HLAB_HUMANRL37A_HUMANIntAct17353931 details
HLAB_HUMANATP5L_HUMANIntAct17353931 details
HLAB_HUMANNDUS1_HUMANIntAct17353931 details
HLAB_HUMANOST48_HUMANIntAct17353931 details
HLAB_HUMANLKHA4_HUMANIntAct17353931 details
HLAB_HUMANMCM7_HUMANIntAct17353931 details
HLAB_HUMANLRC40_HUMANIntAct17353931 details
HLAB_HUMANPCBP1_HUMANIntAct17353931 details
HLAB_HUMANMCTS1_HUMANIntAct17353931 details
HLAB_HUMANSGTA_HUMANIntAct17353931 details
HLAB_HUMANPABP1_HUMANIntAct17353931 details
HLAB_HUMANPIMT_HUMANIntAct17353931 details
HLAB_HUMANECHA_HUMANIntAct17353931 details
HLAB_HUMANBAF_HUMANIntAct17353931 details
HLAB_HUMANSSRA_HUMANIntAct17353931 details
HLAB_HUMANRHOA_HUMANIntAct17353931 details
HLAB_HUMANNP1L1_HUMANIntAct17353931 details
HLAB_HUMANPNPH_HUMANIntAct17353931 details
HLAB_HUMANGFPT1_HUMANIntAct17353931 details
HLAB_HUMANTFR1_HUMANIntAct17353931 details
HLAB_HUMANLRC59_HUMANIntAct17353931 details
HLAB_HUMANHNRPM_HUMANIntAct17353931 details
HLAB_HUMANNUP43_HUMANIntAct17353931 details
HLAB_HUMANSYIM_HUMANIntAct17353931 details
HLAB_HUMANTPM3_HUMANIntAct17353931 details
HLAB_HUMANTBCE_HUMANIntAct17353931 details
HLAB_HUMANSMC3_HUMANIntAct17353931 details
HLAB_HUMANRU2A_HUMANIntAct17353931 details
HLAB_HUMANRAB14_HUMANIntAct17353931 details
HLAB_HUMANGUAA_HUMANIntAct17353931 details
HLAB_HUMANERP29_HUMANIntAct17353931 details
HLAB_HUMANRAB6A_HUMANIntAct17353931 details
HLAB_HUMANTXTP_HUMANIntAct17353931 details
HLAB_HUMANSYMC_HUMANIntAct17353931 details
HLAB_HUMANDNJA1_HUMANIntAct17353931 details
HLAB_HUMANPURA2_HUMANIntAct17353931 details
HLAB_HUMANRL24_HUMANIntAct17353931 details
HLAB_HUMANEIF3H_HUMANIntAct17353931 details
HLAB_HUMANRIR1_HUMANIntAct17353931 details
HLAB_HUMANPROF2_HUMANIntAct17353931 details
HLAB_HUMANRS9_HUMANIntAct17353931 details
HLAB_HUMANSRP72_HUMANIntAct17353931 details
HLAB_HUMANPPCE_HUMANIntAct17353931 details
HLAB_HUMANALDR_HUMANIntAct17353931 details
HLAB_HUMANDUS3_HUMANIntAct17353931 details
HLAB_HUMANTRIPB_HUMANIntAct17353931 details
HLAB_HUMANPFKAL_HUMANIntAct17353931 details
HLAB_HUMANARK72_HUMANIntAct17353931 details
HLAB_HUMANCOPG1_HUMANIntAct17353931 details
HLAB_HUMANMK01_HUMANIntAct17353931 details
HLAB_HUMANGLNA_HUMANIntAct17353931 details
HLAB_HUMANVDAC3_HUMANIntAct17353931 details
HLAB_HUMANNPM_HUMANIntAct17353931 details
HLAB_HUMANNTF2_HUMANIntAct17353931 details
HLAB_HUMANKCRU_HUMANIntAct17353931 details
HLAB_HUMANRTCA_HUMANIntAct17353931 details
HLAB_HUMANPDC6I_HUMANIntAct17353931 details
HLAB_HUMANPSMD2_HUMANIntAct17353931 details
HLAB_HUMANBAP31_HUMANIntAct17353931 details
HLAB_HUMANPYRG1_HUMANIntAct17353931 details
HLAB_HUMANSP16H_HUMANIntAct17353931 details
HLAB_HUMANSC11A_HUMANIntAct17353931 details
HLAB_HUMANPCNA_HUMANIntAct17353931 details
HLAB_HUMANESTD_HUMANIntAct17353931 details
HLAB_HUMANMARE1_HUMANIntAct17353931 details
HLAB_HUMANFETA_HUMANIntAct17353931 details
HLAB_HUMANRFA3_HUMANIntAct17353931 details
HLAB_HUMANCRK_HUMANIntAct17353931 details
HLAB_HUMANCPSF6_HUMANIntAct17353931 details
HLAB_HUMANSEC13_HUMANIntAct17353931 details
HLAB_HUMANPSA_HUMANIntAct17353931 details
HLAB_HUMANRL23A_HUMANIntAct17353931 details
HLAB_HUMANFUS_HUMANIntAct17353931 details
HLAB_HUMANCYC_HUMANIntAct17353931 details
HLAB_HUMANERF3A_HUMANIntAct17353931 details
HLAB_HUMANARP2_HUMANIntAct17353931 details
HLAB_HUMANARPC2_HUMANIntAct17353931 details
HLAB_HUMANGARS_HUMANIntAct17353931 details
HLAB_HUMANPRS10_HUMANIntAct17353931 details
HLAB_HUMANTEBP_HUMANIntAct17353931 details
HLAB_HUMANTRAP1_HUMANIntAct17353931 details
HLAB_HUMANNU155_HUMANIntAct17353931 details
HLAB_HUMANEXOS4_HUMANIntAct17353931 details
HLAB_HUMANTCTP_HUMANIntAct17353931 details
HLAB_HUMANCBR1_HUMANIntAct17353931 details
HLAB_HUMANMYL6_HUMANIntAct17353931 details
HLAB_HUMANACPH_HUMANIntAct17353931 details
HLAB_HUMANTPSNR_HUMANIntAct26439010 details
HLAB_HUMANKI3S1_HUMANIntAct27649529 details
HLAB_HUMANKI3L1_HUMANHPRD, IntAct12134147 27649529 8046332 details
HLAB_HUMANLIRB2_HUMANIntAct27649529 details
HLAB_HUMANH2A1B_HUMANIntAct30021884 details
HLAB_HUMANBIP_HUMANBioGRID24155957 details
HLAB_HUMANHLAB_HUMANBioGRID, HPRD12853576 25132672 9531263 details
HLAB_HUMANEDEM1_HUMANBioGRID25132672 details
HLAB_HUMANCXCR4_HUMANBioGRID18083706 details
HLAB_HUMANCALR_HUMANBioGRID11823531 details
HLAB_HUMANTAP1_HUMANBioGRID11823531 details
HLAB_HUMANPDIA3_HUMANBioGRID11823531 details
HLAB_HUMANCSF1_HUMANHPRD15494511 details
HLAB_HUMANSRC_HUMANHPRD6304688 details
HLAB_HUMANMAGA1_HUMANHPRD10363990 details
HLAB_HUMANKLRD1_HUMANHPRD8046333 details