Entity Details

Primary name EST1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23141
EntryNameEST1_HUMAN
FullNameLiver carboxylesterase 1
TaxID9606
Evidenceevidence at protein level
Length567
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesCES1

GO terms

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GOName
GO:0002003 angiotensin maturation
GO:0004771 sterol esterase activity
GO:0004806 triglyceride lipase activity
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005811 lipid droplet
GO:0005829 cytosol
GO:0006695 cholesterol biosynthetic process
GO:0006805 xenobiotic metabolic process
GO:0008203 cholesterol metabolic process
GO:0009636 response to toxic substance
GO:0010875 positive regulation of cholesterol efflux
GO:0010887 negative regulation of cholesterol storage
GO:0016042 lipid catabolic process
GO:0030855 epithelial cell differentiation
GO:0042632 cholesterol homeostasis
GO:0043691 reverse cholesterol transport
GO:0047374 methylumbelliferyl-acetate deacetylase activity
GO:0051791 medium-chain fatty acid metabolic process
GO:0052689 carboxylic ester hydrolase activity
GO:0070857 regulation of bile acid biosynthetic process
GO:0071397 cellular response to cholesterol
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0080030 methyl indole-3-acetate esterase activity
GO:0090122 cholesterol ester hydrolysis involved in cholesterol transport
GO:0090205 positive regulation of cholesterol metabolic process
GO:0120188 regulation of bile acid secretion

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum lumen
Lipid droplet

Domains

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DomainNameCategoryType
IPR002018 Carboxylesterase, type BDomainDomain
IPR019819 Carboxylesterase type B, conserved siteSiteConserved site
IPR019826 Carboxylesterase type B, active siteSiteActive site
IPR029058 Alpha/Beta hydrolase foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00198 OseltamivirDrugbanksmall molecule
DB00328 IndomethacinDrugbanksmall molecule
DB00382 TacrineDrugbanksmall molecule
DB00454 MeperidineDrugbanksmall molecule
DB00519 TrandolaprilDrugbanksmall molecule
DB00583 LevocarnitineDrugbanksmall molecule
DB00647 DextropropoxypheneDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00688 Mycophenolate mofetilDrugbanksmall molecule
DB00758 ClopidogrelDrugbanksmall molecule
DB00762 IrinotecanDrugbanksmall molecule
DB00881 QuinaprilDrugbanksmall molecule
DB00907 CocaineDrugbanksmall molecule
DB01039 FenofibrateDrugbanksmall molecule
DB01086 BenzocaineDrugbanksmall molecule
DB01101 CapecitabineDrugbanksmall molecule
DB01183 NaloxoneDrugbanksmall molecule
DB01410 CiclesonideDrugbanksmall molecule
DB01452 DiamorphineDrugbanksmall molecule
DB01599 ProbucolDrugbanksmall molecule
DB02161 Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl EsterDrugbanksmall molecule
DB02659 Cholic AcidDrugbanksmall molecule
DB03056 4-Piperidino-PiperidineDrugbanksmall molecule
DB03721 N-acetyl-alpha-neuraminic acidDrugbanksmall molecule
DB04795 ThenoyltrifluoroacetoneDrugbanksmall molecule
DB04838 CyclandelateDrugbanksmall molecule
DB06201 RufinamideDrugbanksmall molecule
DB06442 AvasimibeDrugbanksmall molecule
DB06693 MevastatinDrugbanksmall molecule
DB06695 Dabigatran etexilateDrugbanksmall molecule
DB07821 (1R)-1,2,2-trimethylpropyl (R)-methylphosphinateDrugbanksmall molecule
DB08224 (1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOLDrugbanksmall molecule
DB09269 Phenylacetic acidSwissprotsmall molecule
DB09299 Tenofovir alafenamideDrugbanksmall molecule
DB09342 PropoxycaineDrugbanksmall molecule
DB11181 HomatropineDrugbanksmall molecule
DB11362 SelexipagDrugbanksmall molecule
DB12404 RemimazolamDrugbanksmall molecule
DB14761 RemdesivirDrugbanksmall molecule
DB14845 FilgotinibDrugbanksmall molecule