Entity Details

Primary name RASA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20936
EntryNameRASA1_HUMAN
FullNameRas GTPase-activating protein 1
TaxID9606
Evidenceevidence at protein level
Length1047
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesRASA1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000281 mitotic cytokinesis
GO:0001570 vasculogenesis
GO:0001726 ruffle
GO:0001784 phosphotyrosine residue binding
GO:0001953 negative regulation of cell-matrix adhesion
GO:0005096 GTPase activator activity
GO:0005102 signaling receptor binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007162 negative regulation of cell adhesion
GO:0007165 signal transduction
GO:0008360 regulation of cell shape
GO:0019870 potassium channel inhibitor activity
GO:0030833 regulation of actin filament polymerization
GO:0035556 intracellular signal transduction
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048013 ephrin receptor signaling pathway
GO:0048514 blood vessel morphogenesis
GO:0051020 GTPase binding
GO:0051252 regulation of RNA metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR001936 Ras GTPase-activating domainDomainDomain
IPR008936 Rho GTPase activation proteinFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR023152 Ras GTPase-activating protein, conserved siteSiteConserved site
IPR028554 Ras GTPase-activating protein 1FamilyFamily
IPR035652 RasGAP, SH3 domainDomainDomain
IPR035841 Ras GTPase-activating protein 1, N-terminal SH2 domainDomainDomain
IPR035842 Ras GTPase-activating protein 1, C-terminal SH2 domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR039360 Ras GTPase-activating proteinFamilyFamily

Diseases

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Interactions

109 interactions

InteractorPartnerSourcesPublicationsLink
RASA1_HUMANERBB3_HUMANBioGRID, MINT16273093 22973453 details
RASA1_HUMANERBB2_HUMANBioGRID, MINT16273093 22973453 24412244 details
RASA1_HUMANEGFR_HUMANBioGRID, HPRD, MINT1385407 16273093 1633149 1850098 22973453 8647858 details
RASA1_HUMANERBB4_HUMANBioGRID, MINT16273093 22973453 details
RASA1_HUMANRASH_HUMANBioGRID, HPRD, IntAct11389730 26721396 2833817 7628625 8663024 9219684 details
RASA1_HUMANTSC1_HUMANIntAct17355907 details
RASA1_HUMANGAB1_HUMANBioGRID, IntAct, MINT15574420 24728074 details
RASA1_HUMANRHG07_HUMANBioGRID, MINT19151751 24412244 details
RASA1_HUMANKHDR1_HUMANBioGRID, HPRD, IntAct11604231 1385407 1545818 7537265 8189062 8419471 9743338 details
RASA1_HUMANCPNS1_HUMANMINT18761085 details
RASA1_HUMANABI1_HUMANMINT20598684 details
RASA1_HUMANIGF1R_HUMANBioGRID, HPRD, MINT7642582 details
RASA1_HUMANCAV1_HUMANDIP, MINT15504032 20808760 details
RASA1_HUMANSOCS3_HUMANBioGRID, HPRD, MINT11331873 details
RASA1_HUMANNCK1_HUMANBioGRID, HPRD, IntAct10508618 21664272 9233798 details
RASA1_HUMANBBS10_HUMANBioGRID, MINT21900206 details
RASA1_HUMANEIF1_HUMANBioGRID, MINT21900206 details
RASA1_HUMANEZH2_HUMANBioGRID, MINT21900206 details
RASA1_HUMANKAIN_HUMANBioGRID, MINT21900206 details
RASA1_HUMANTRM2A_HUMANBioGRID, MINT21900206 details
RASA1_HUMANXRCC6_HUMANBioGRID, MINT21900206 details
RASA1_HUMANZN579_HUMANBioGRID, MINT21900206 details
RASA1_HUMANAPC_HUMANBioGRID, MINT24412244 details
RASA1_HUMANAURKA_HUMANBioGRID, MINT24412244 details
RASA1_HUMANBCL10_HUMANBioGRID, MINT24412244 details
RASA1_HUMANBMR1A_HUMANBioGRID, MINT24412244 details
RASA1_HUMANBUB1_HUMANBioGRID, MINT24412244 details
RASA1_HUMANARF_HUMANBioGRID, MINT24412244 details
RASA1_HUMANDCC_HUMANBioGRID, MINT24412244 details
RASA1_HUMANMLH3_HUMANBioGRID, MINT24412244 details
RASA1_HUMANRASN_HUMANBioGRID, MINT24412244 details
RASA1_HUMANPMS2_HUMANBioGRID, MINT24412244 details
RASA1_HUMANPTPRJ_HUMANBioGRID, MINT24412244 details
RASA1_HUMANRB_HUMANBioGRID, MINT24412244 details
RASA1_HUMANSMAD2_HUMANBioGRID, MINT24412244 details
RASA1_HUMANSTK11_HUMANBioGRID, MINT24412244 details
RASA1_HUMANANDR_HUMANBioGRID, IntAct24728074 details
RASA1_HUMANKIT_HUMANBioGRID, HPRD, IntAct11071635 24728074 details
RASA1_HUMANMET_HUMANBioGRID, IntAct24728074 details
RASA1_HUMANOLIG1_HUMANBioGRID, IntAct25814554 details
RASA1_HUMANGMCL1_HUMANBioGRID, IntAct32296183 details
RASA1_HUMANFLT3_HUMANMINT28086240 details
RASA1_HUMANHD_HUMANBioGRID, HPRD, IntAct32814053 9079622 details
RASA1_HUMANDOK1_HUMANBioGRID, HPRD10688886 10799545 10822173 11551902 15151996 22974441 9008161 9478921 9822717 details
RASA1_HUMANSL9A2_HUMANBioGRID, HPRD10187839 details
RASA1_HUMANRHG35_HUMANBioGRID8189062 8419471 9034330 details
RASA1_HUMANEPHB2_HUMANBioGRID, HPRD10644995 9233798 details
RASA1_HUMANSRC_HUMANBioGRID, HPRD11389730 1717825 details
RASA1_HUMANANXA6_HUMANBioGRID, HPRD10571081 8798684 details
RASA1_HUMANEPHB3_HUMANBioGRID, HPRD9674711 details
RASA1_HUMANDNJA3_HUMANBioGRID, HPRD11116152 details
RASA1_HUMANCSK_HUMANBioGRID, HPRD7544435 details
RASA1_HUMANCAV2_HUMANBioGRID, HPRD12091389 15504032 details
RASA1_HUMANHCK_HUMANBioGRID, HPRD7782336 details
RASA1_HUMANRACK1_HUMANBioGRID, HPRD11350068 details
RASA1_HUMANFAK2_HUMANBioGRID, HPRD10708762 10713673 details
RASA1_HUMANLCK_HUMANBioGRID, HPRD11389730 1850098 details
RASA1_HUMANA4_HUMANBioGRID21832049 details
RASA1_HUMANFGFR1_HUMANBioGRID8321198 details
RASA1_HUMANRASA1_HUMANBioGRID, HPRD11976319 31980649 details
RASA1_HUMANCDN2A_HUMANBioGRID24412244 details
RASA1_HUMANPDE6D_HUMANHPRD11786539 details
RASA1_HUMANAURKB_HUMANHPRD11976319 details
RASA1_HUMANPLCG1_HUMANBioGRID, MINT8977179 9020117 9743338 details
RASA1_HUMANINSR_HUMANBioGRID, HPRD, MINT1331107 9593725 details
RASA1_HUMANATF7_HUMANIntAct20195357 details
RASA1_HUMANPGFRB_HUMANBioGRID, HPRD, MINT10697503 11896619 1314164 1375321 8382774 details
RASA1_HUMANCD5_HUMANBioGRID, HPRD, MINT9603468 details
RASA1_HUMANSDC2_HUMANMolecular Connections22471946 details
RASA1_HUMANTE2IP_HUMANDIP25531777 details
RASA1_HUMANEPHA4_HUMANIntAct31413325 details
RASA1_HUMANDOK2_HUMANBioGRID, HPRD10428862 10508618 10799545 10822173 9478921 details
RASA1_HUMANM4K4_HUMANBioGRID, HPRD10669731 details
RASA1_HUMANPAXI_HUMANBioGRID, HPRD10092539 details
RASA1_HUMANZAP70_HUMANBioGRID, HPRD7760813 details
RASA1_HUMANYES_HUMANBioGRID, HPRD1544885 details
RASA1_HUMANVGFR2_HUMANBioGRID, HPRD10319320 details
RASA1_HUMANGRB2_HUMANBioGRID, HPRD12441060 details
RASA1_HUMANG3BP1_HUMANBioGRID, HPRD9632780 details
RASA1_HUMANSPSB1_HUMANBioGRID, HPRD15713673 details
RASA1_HUMANSOCS1_HUMANBioGRID18556463 29991678 details
RASA1_HUMANABL1_HUMANBioGRID, HPRD1383690 1571536 details
RASA1_HUMANNTRK1_HUMANBioGRID, HPRD25921289 8384556 details
RASA1_HUMANPGFRA_HUMANBioGRID7682895 details
RASA1_HUMANBCR_HUMANHPRD1383690 details
RASA1_HUMANCH60_HUMANHPRD1347942 details
RASA1_HUMANEPHA2_HUMANHPRD16051609 details
RASA1_HUMANLYN_HUMANHPRD8395016 details
RASA1_HUMANKSYK_HUMANHPRD9218456 details
RASA1_HUMANSHC1_HUMANHPRD8155326 details
RASA1_HUMANAF1L2_HUMANHPRD17412687 details
RASA1_HUMANPTPRC_HUMANHPRD8570203 details
RASA1_HUMANCSF1R_HUMANHPRD2172781 details
RASA1_HUMANP85A_HUMANHPRD1336372 details
RASA1_HUMANRAB5A_HUMANHPRD11536198 details
RASA1_HUMANRAP1A_HUMANHPRD2164710 details
RASA1_HUMANFES_HUMANHPRD7691175 details
RASA1_HUMANSYN1_HUMANHPRD10899172 details
RASA1_HUMANCASP3_HUMANHPRD10200531 details
RASA1_HUMANSTAU1_HUMANHPRD15121898 details
RASA1_HUMANCASP7_HUMANHPRD10200531 details
RASA1_HUMANWWP1_HUMANHPRD9169421 details
RASA1_HUMANWWP2_HUMANHPRD9169421 details
RASA1_HUMANMAGI1_HUMANHPRD9169421 details
RASA1_HUMANRHG05_HUMANHPRD8537347 details
RASA1_HUMANRHG01_HUMANHPRD9034330 details
RASA1_HUMANBIRC5_HUMANHPRD11976319 details
RASA1_HUMANPHAG1_HUMANHPRD10790433 details
RASA1_HUMANDOK4_HUMANHPRD12730241 details