Entity Details

Primary name MCM2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49736
EntryNameMCM2_HUMAN
FullNameDNA replication licensing factor MCM2
TaxID9606
Evidenceevidence at protein level
Length904
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesMCM2

GO terms

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GOName
GO:0000727 double-strand break repair via break-induced replication
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005664 nuclear origin of replication recognition complex
GO:0005737 cytoplasm
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006334 nucleosome assembly
GO:0006915 apoptotic process
GO:0016787 hydrolase activity
GO:0019899 enzyme binding
GO:0036388 pre-replicative complex assembly
GO:0042393 histone binding
GO:0042555 MCM complex
GO:0046872 metal ion binding
GO:0071162 CMG complex
GO:0071353 cellular response to interleukin-4
GO:0090102 cochlea development
GO:1902975 mitotic DNA replication initiation
GO:1905775 negative regulation of DNA helicase activity

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR001208 MCM domainDomainDomain
IPR008045 DNA replication licensing factor Mcm2FamilyFamily
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR018525 Mini-chromosome maintenance, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR027925 MCM N-terminal domainDomainDomain
IPR031327 Mini-chromosome maintenance proteinFamilyFamily
IPR033762 MCM OB domainDomainDomain
IPR041562 MCM, AAA-lid domainDomainDomain

Diseases

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Disease IDSourceNameDescription
616968 OMIMDeafness, autosomal dominant, 70 (DFNA70)A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA70 is characterized by slowly progressive, postlingual hearing impairment. The disease is caused by variants affecting the gene represented in this entry.

Interactions

118 interactions

InteractorPartnerSourcesPublicationsLink
MCM2_HUMANORC6_HUMANBioGRID, HPRD, IntAct15232106 details
MCM2_HUMANMCM3_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt12614612 15232106 16899510 17296731 22540012 23993743 25963833 26167883 26344197 27621311 28514442 30108253 31467278 details
MCM2_HUMANMCM10_HUMANBioGRID, HPRD, IntAct11095689 15232106 details
MCM2_HUMANORC2_HUMANBioGRID, HPRD, IntAct12614612 15232106 details
MCM2_HUMANMCM5_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11248027 12614612 15232106 16899510 17296731 22540012 22939629 23993743 24207054 25963833 26344197 details
MCM2_HUMANCDK6_HUMANBioGRID, HPRD, IntAct15232106 details
MCM2_HUMANCCNB2_HUMANBioGRID, HPRD, IntAct15232106 details
MCM2_HUMANMCM7_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10567526 10748114 12207017 12614612 12694531 15232106 16899510 17296731 22540012 22863883 22939629 23764002 25963833 26186194 26344197 27173435 30100344 8798650 9099751 unassigned1312 details
MCM2_HUMANORC5_HUMANBioGRID, HPRD, IntAct12614612 15232106 details
MCM2_HUMANCDK4_HUMANBioGRID, HPRD, IntAct15232106 details
MCM2_HUMANCDN2A_HUMANBioGRID, IntAct15232106 details
MCM2_HUMANMPP3_HUMANBioGRID, HPRD, IntAct16169070 details
MCM2_HUMANPHC2_HUMANBioGRID, HPRD, IntAct16169070 details
MCM2_HUMANMCM6_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt10567526 12207017 12614612 12694531 16189514 16899510 17296731 20211142 22540012 22863883 22939629 25416956 25963833 26167883 26344197 26496610 27173435 30100344 unassigned1312 details
MCM2_HUMANCDC6_HUMANBioGRID, HPRD, IntAct15232106 23405012 details
MCM2_HUMANGNB5_HUMANBioGRID, HPRD, IntAct16169070 details
MCM2_HUMANRS4X_HUMANBioGRID, HPRD, IntAct16169070 25963833 details
MCM2_HUMANELL_HUMANBioGRID, MINT19819239 details
MCM2_HUMANCDC7_HUMANBioGRID, HPRD, UniProt10523313 10846177 11568184 12614612 16446360 16826239 16899510 17927916 18286467 22540012 23066029 30392930 details
MCM2_HUMANPHOCN_HUMANBioGRID, HPRD, IntAct16169070 details
MCM2_HUMANMCM4_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10567526 12614612 12694531 16899510 16902406 17296731 22540012 22863883 22939629 23764002 25963833 26344197 27173435 8798650 unassigned1312 details
MCM2_HUMANSNF8_HUMANBioGRID, MINT19819239 details
MCM2_HUMANEP300_HUMANBioGRID, MINT20808282 30110629 details
MCM2_HUMANP2RX4_HUMANBioGRID, IntAct21988832 details
MCM2_HUMANCSK21_HUMANBioGRID, IntAct22113938 details
MCM2_HUMANTE2IP_HUMANbhf-ucl, BioGRID21044950 details
MCM2_HUMANASF1A_HUMANBioGRID, DIP, IntAct, MINT22407294 23602572 24981860 25963833 26167883 28514442 32296183 details
MCM2_HUMANCDC45_HUMANBioGRID, DIP19805216 22374673 26167883 30392930 details
MCM2_HUMANPSF3_HUMANBioGRID, DIP19805216 26186194 details
MCM2_HUMANDBF4A_HUMANBioGRID, HPRD10846177 12614612 18286467 22540012 details
MCM2_HUMANMCM2_HUMANBioGRID, HPRD12614612 15232106 25963833 details
MCM2_HUMANAKAP8_HUMANBioGRID, HPRD, UniProt12740381 details
MCM2_HUMANRFA1_HUMANBioGRID, HPRD12614612 25963833 details
MCM2_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
MCM2_HUMANKAT7_HUMANBioGRID, HPRD11278932 16428461 details
MCM2_HUMANSIK1_HUMANBioGRID27592030 details
MCM2_HUMANSLD5_HUMANBioGRID22374673 27592030 30392930 details
MCM2_HUMANRFA3_HUMANBioGRID, HPRD12614612 details
MCM2_HUMANORC1_HUMANBioGRID, HPRD12614612 details
MCM2_HUMANA4_HUMANBioGRID21832049 details
MCM2_HUMANATM_HUMANBioGRID15210935 details
MCM2_HUMANORC4_HUMANBioGRID, HPRD12614612 details
MCM2_HUMANATR_HUMANBioGRID15210935 details
MCM2_HUMANTCEA2_HUMANBioGRID12392551 details
MCM2_HUMANRFA2_HUMANBioGRID, HPRD12614612 details
MCM2_HUMANTBP_HUMANBioGRID, HPRD12392551 details
MCM2_HUMANCCNC_HUMANBioGRID12392551 details
MCM2_HUMANMCPH1_HUMANBioGRID19525936 details
MCM2_HUMANCDK2_HUMANBioGRID16446360 21319273 details
MCM2_HUMANCDT1_HUMANBioGRID21930785 details
MCM2_HUMANARF_HUMANBioGRID, HPRD15232106 details
MCM2_HUMANFBX7_HUMANBioGRID27503909 details
MCM2_HUMANESCO2_HUMANBioGRID30100344 details
MCM2_HUMANPHB_HUMANBioGRID19377303 details
MCM2_HUMANPTEN_HUMANBioGRID31685992 details
MCM2_HUMANCHK1_HUMANBioGRID25049228 details
MCM2_HUMANSSRP1_HUMANBioGRID, IntAct, MINT16902406 21055985 24981860 28514442 details
MCM2_HUMANPLK1_HUMANBioGRID, HPRD, IntAct15654075 27173435 unassigned1312 details
MCM2_HUMANIKKE_HUMANIntAct17353931 details
MCM2_HUMANH4_HUMANBioGRID, DIP, IntAct19862764 25963833 26167883 27248496 28514442 details
MCM2_HUMANTONSL_HUMANBioGRID, MINT21055984 21055985 21113133 details
MCM2_HUMANMCMBP_HUMANBioGRID, IntAct, MINT22540012 24299456 25036637 25963833 details
MCM2_HUMANCCNA1_HUMANIntAct17353931 details
MCM2_HUMANEP15R_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANATG2B_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANHSF1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANWEE1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANSBNO1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANGAPD1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANPP4R2_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANRELCH_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANBCR_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANSMC3_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANTF3C2_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANJIP4_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANUBP15_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANCD11A_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANNS1BP_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANANK3_HUMANBioGRID, IntAct25963833 27173435 unassigned1312 details
MCM2_HUMANTF3C4_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANASF1B_HUMANBioGRID, DIP, IntAct, MINT20227376 24981860 25963833 26167883 26527279 28514442 details
MCM2_HUMANSF3A1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANSOX4_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANSMC1A_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANH31_HUMANBioGRID, DIP, IntAct25963833 26167883 26527279 28514442 details
MCM2_HUMANLMBL1_HUMANBioGRID, DIP, IntAct21149733 28514442 details
MCM2_HUMANP4R3A_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANMGMT_HUMANBioGRID16226712 details
MCM2_HUMANPGK1_HUMANBioGRID25963833 30392930 details
MCM2_HUMANH2B1B_HUMANBioGRID25963833 27248496 30104407 details
MCM2_HUMANH2A1B_HUMANBioGRID25963833 27248496 30104407 details
MCM2_HUMANFACD2_HUMANBioGRID23993743 24658369 31180492 details
MCM2_HUMANEMD_HUMANBioGRID17620012 details
MCM2_HUMANHDAC5_HUMANBioGRID21081666 details
MCM2_HUMANHJURP_HUMANDIP26167883 details
MCM2_HUMANRAD52_HUMANBioGRID, HPRD15766559 details
MCM2_HUMANCCND1_HUMANBioGRID12519773 details
MCM2_HUMANCENPA_HUMANDIP26167883 details
MCM2_HUMANING5_HUMANBioGRID16387653 details
MCM2_HUMANTF2H1_HUMANHPRD12392551 details
MCM2_HUMANAIRE_HUMANBioGRID20085707 details
MCM2_HUMANMMS22_HUMANBioGRID21055985 details
MCM2_HUMANCCL2_HUMANBioGRID21383955 details
MCM2_HUMANH31T_HUMANBioGRID, HPRD25963833 8798650 details
MCM2_HUMANATRIP_HUMANBioGRID21775519 details
MCM2_HUMANFANCI_HUMANBioGRID25843623 details
MCM2_HUMANRPB1_HUMANBioGRID10454562 details
MCM2_HUMANSPRTN_HUMANBioGRID27871366 details
MCM2_HUMANRN126_HUMANBioGRID26508657 details
MCM2_HUMANRECQ4_HUMANBioGRID19696745 29229926 details
MCM2_HUMANTCEA1_HUMANBioGRID10454562 details
MCM2_HUMANPCNA_HUMANBioGRID32900933 details
MCM2_HUMANTF2B_HUMANHPRD12392551 details
MCM2_HUMANDPOLA_HUMANBioGRID11259605 details
MCM2_HUMANCPSF1_HUMANHPRD12392551 details
MCM2_HUMANKEAP1_HUMANBioGRID27621311 details
MCM2_HUMANDONS_HUMANBioGRID28191891 details
MCM2_HUMANUBR5_HUMANBioGRID31586398 details