Entity Details

Primary name PLCB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NQ66
EntryNamePLCB1_HUMAN
FullName1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
TaxID9606
Evidenceevidence at protein level
Length1216
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesPLCB1

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000785 chromatin
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0005096 GTPase activator activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005521 lamin binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
GO:0007215 glutamate receptor signaling pathway
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007613 memory
GO:0008277 regulation of G protein-coupled receptor signaling pathway
GO:0016042 lipid catabolic process
GO:0016607 nuclear speck
GO:0019899 enzyme binding
GO:0021987 cerebral cortex development
GO:0031965 nuclear membrane
GO:0032735 positive regulation of interleukin-12 production
GO:0032991 protein-containing complex
GO:0035722 interleukin-12-mediated signaling pathway
GO:0035723 interleukin-15-mediated signaling pathway
GO:0040019 positive regulation of embryonic development
GO:0042802 identical protein binding
GO:0043647 inositol phosphate metabolic process
GO:0045444 fat cell differentiation
GO:0045663 positive regulation of myoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046330 positive regulation of JNK cascade
GO:0046488 phosphatidylinositol metabolic process
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048639 positive regulation of developmental growth
GO:0060466 activation of meiosis involved in egg activation
GO:0070062 extracellular exosome
GO:0070498 interleukin-1-mediated signaling pathway
GO:0080154 regulation of fertilization
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0099170 postsynaptic modulation of chemical synaptic transmission
GO:0099178 regulation of retrograde trans-synaptic signaling by endocanabinoid
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1903140 regulation of establishment of endothelial barrier
GO:2000344 positive regulation of acrosome reaction
GO:2000438 negative regulation of monocyte extravasation
GO:2000560 positive regulation of CD24 production

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus membrane

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000909 Phosphatidylinositol-specific phospholipase C, X domainDomainDomain
IPR001192 Phosphoinositide phospholipase C familyFamilyFamily
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domainDomainDomain
IPR009535 Phospholipase C-beta, conserved siteSiteConserved site
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR014815 Phospholipase C-beta, C-terminal domainDomainDomain
IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domainDomainDomain
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase betaFamilyFamily
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamilyFamilyHomologous superfamily
IPR028400 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1FamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR037862 PLC-beta, PH domainDomainDomain
IPR042531 Phospholipase C-beta, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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