Entity Details

Primary name MUTYH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UIF7
EntryNameMUTYH_HUMAN
FullNameAdenine DNA glycosylase
TaxID9606
Evidenceevidence at protein level
Length546
SequenceStatuscomplete
DateCreated2004-06-07
DateModified2021-06-02

Ontological Relatives

GenesMUTYH

GO terms

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GOName
GO:0000701 purine-specific mismatch base pair DNA N-glycosylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006298 mismatch repair
GO:0032357 oxidized purine DNA binding
GO:0032407 MutSalpha complex binding
GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
GO:0035485 adenine/guanine mispair binding
GO:0045007 depurination
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding

Subcellular Location

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Subcellular Location
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000086 NUDIX hydrolase domainDomainDomain
IPR000445 Helix-hairpin-helix motifSiteConserved site
IPR003265 HhH-GPD domainDomainDomain
IPR003651 Endonuclease III-like, iron-sulphur cluster loop motifSiteConserved site
IPR004035 Endonuclease III, iron-sulphur binding siteSiteBinding site
IPR004036 Endonuclease III-like, conserved site-2SiteConserved site
IPR011257 DNA glycosylaseFamilyHomologous superfamily
IPR015797 NUDIX hydrolase-like domain superfamilyFamilyHomologous superfamily
IPR023170 Helix-hairpin-helix, base-excision DNA repair, C-terminalFamilyHomologous superfamily
IPR029119 MutY, C-terminalDomainDomain
IPR044298 Adenine/Thymine-DNA glycosylaseFamilyFamily

Diseases

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