Entity Details

Primary name ATAD1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8NBU5
EntryNameATAD1_HUMAN
FullNameOuter mitochondrial transmembrane helix translocase
TaxID9606
Evidenceevidence at protein level
Length361
SequenceStatuscomplete
DateCreated2005-09-13
DateModified2021-06-02

Ontological Relatives

GenesATAD1

GO terms

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GOName
GO:0002092 positive regulation of receptor internalization
GO:0005524 ATP binding
GO:0005741 mitochondrial outer membrane
GO:0005778 peroxisomal membrane
GO:0005829 cytosol
GO:0007612 learning
GO:0007613 memory
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016887 ATP hydrolysis activity
GO:0045046 protein import into peroxisome membrane
GO:0045211 postsynaptic membrane
GO:0051967 negative regulation of synaptic transmission, glutamatergic
GO:0098978 glutamatergic synapse
GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization
GO:0140567 transmembrane protein dislocase activity
GO:0140570 extraction of mislocalized protein from mitochondrial outer membrane

Subcellular Location

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Subcellular Location
Cell junction
Mitochondrion outer membrane
Peroxisome membrane

Domains

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DomainNameCategoryType
IPR003593 AAA+ ATPase domainDomainDomain
IPR003959 ATPase, AAA-type, coreDomainDomain
IPR003960 ATPase, AAA-type, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR041569 AAA ATPase, AAA+ lid domainDomainDomain

Diseases

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Disease IDSourceNameDescription
618011 OMIMHyperekplexia 4 (HKPX4)An autosomal recessive severe neurologic disorder apparent from birth. HKPX4 is characterized by little if any development, hypertonia, early-onset refractory seizures in some patients, and respiratory failure resulting in early death, mostly in the first months of life. The disease is caused by variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
ATAD1_HUMANGOSR1_HUMANBioGRID, MINT24843043 details
ATAD1_HUMANANKS6_HUMANBioGRID, IntAct27173435 unassigned1312 details