Entity Details

Primary name PK3C3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8NEB9
EntryNamePK3C3_HUMAN
FullNamePhosphatidylinositol 3-kinase catalytic subunit type 3
TaxID9606
Evidenceevidence at protein level
Length887
SequenceStatuscomplete
DateCreated2005-12-06
DateModified2021-06-02

Ontological Relatives

GenesPIK3C3

GO terms

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GOName
GO:0000045 autophagosome assembly
GO:0000407 phagophore assembly site
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005770 late endosome
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0005930 axoneme
GO:0006497 protein lipidation
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006897 endocytosis
GO:0006914 autophagy
GO:0007049 cell cycle
GO:0016020 membrane
GO:0016236 macroautophagy
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0030242 autophagy of peroxisome
GO:0030496 midbody
GO:0030670 phagocytic vesicle membrane
GO:0032465 regulation of cytokinesis
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I
GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II
GO:0035032 phosphatidylinositol 3-kinase complex, class III
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0042149 cellular response to glucose starvation
GO:0044754 autolysosome
GO:0045022 early endosome to late endosome transport
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051301 cell division
GO:0052742 phosphatidylinositol kinase activity

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Late endosome
Midbody

Domains

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DomainNameCategoryType
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domainDomainDomain
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domainDomainDomain
IPR002420 C2 phosphatidylinositol 3-kinase-type domainDomainDomain
IPR008290 Phosphatidylinositol 3-kinase, Vps34 typeFamilyFamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015433 Phosphatidylinositol kinaseFamilyFamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR018936 Phosphatidylinositol 3/4-kinase, conserved siteSiteConserved site
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamilyFamilyHomologous superfamily
IPR042236 Phosphoinositide 3-kinase, accessory (PIK) domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB06836 N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamideDrugbanksmall molecule

Interactions

55 interactions

InteractorPartnerSourcesPublicationsLink
PK3C3_HUMANBECN1_HUMANBioGRID, DIP, IntAct, matrixdb, UniProt16179260 16390869 18628207 18843052 19050071 19270693 19270696 19372752 19713971 20562859 20711182 21936852 23315026 23316280 23332761 23364696 23822101 23878393 23954414 23974797 24034250 24056303 24166503 24472739 24785657 24879154 24980959 24980960 25086043 25275521 25490155 25594178 25693418 25825496 25906440 26496610 26549445 26783301 27304906 27621469 28059666 28128446 28351972 28404643 28431397 28757208 28846113 29079782 29321306 29587298 29604308 30258449 30686098 30978004 31373534 31696776 31955515 33422265 details
PK3C3_HUMANRUBIC_HUMANBioGRID, IntAct, UniProt19270696 20562859 21062745 24980960 25533187 30686098 details
PK3C3_HUMANBAKOR_HUMANBioGRID, DIP, IntAct, UniProt18843052 19050071 19270696 20562859 22493499 23262492 23332761 24141421 24166503 24785657 24980960 25086043 25275521 25490155 26549445 27621469 28059666 28238651 28404643 28431397 28514442 28757208 29313410 30978004 31696776 33422265 details
PK3C3_HUMANNRBF2_HUMANBioGRID, IntAct, UniProt20562859 24785657 24849286 25086043 26186194 28059666 28514442 details
PK3C3_HUMANPI3R4_HUMANBioGRID, HPRD, IntAct, UniProt20562859 24166503 24785657 24849286 26344197 26549445 28757208 30978004 8999962 details
PK3C3_HUMAN1433T_HUMANBioGRID7479742 details
PK3C3_HUMANFXL20_HUMANBioGRID25593308 details
PK3C3_HUMANCASP8_HUMANBioGRID28846113 details
PK3C3_HUMANSTYK1_HUMANBioGRID31696776 details
PK3C3_HUMANOTU7B_HUMANBioGRID32453962 details
PK3C3_HUMANPDPK1_HUMANBioGRID32876514 details
PK3C3_HUMAN1433G_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 28514442 details
PK3C3_HUMANUVRAG_HUMANBioGRID, DIP, IntAct, UniProt18843052 20562859 22493499 24056303 24785657 24849286 24980960 25086043 25275521 25490155 30686098 30978004 31373534 details
PK3C3_HUMANRB39A_HUMANUniProt24349490 details
PK3C3_HUMANRAB5A_HUMANBioGRID15016378 15328530 34079125 details
PK3C3_HUMANKRIT1_HUMANBioGRID12925680 details
PK3C3_HUMANMYH9_HUMANBioGRID23569248 details
PK3C3_HUMANMYH1_HUMANBioGRID23569248 details
PK3C3_HUMANKIF1B_HUMANBioGRID23569248 details
PK3C3_HUMANDREB_HUMANBioGRID23569248 details
PK3C3_HUMANTIF1B_HUMANBioGRID23569248 details
PK3C3_HUMANHS90A_HUMANBioGRID23569248 details
PK3C3_HUMANBIP_HUMANBioGRID23569248 details
PK3C3_HUMANHS71A_HUMANBioGRID23569248 details
PK3C3_HUMANHS71B_HUMANBioGRID23569248 details
PK3C3_HUMANANM5_HUMANBioGRID23569248 details
PK3C3_HUMANEXOC8_HUMANBioGRID21241894 details
PK3C3_HUMANEXOC2_HUMANBioGRID21241894 details
PK3C3_HUMANPRKN_HUMANBioGRID24879156 details
PK3C3_HUMANDACT1_HUMANBioGRID24980960 details
PK3C3_HUMANRING2_HUMANBioGRID24980959 details
PK3C3_HUMANAMRA1_HUMANBioGRID20921139 details
PK3C3_HUMANUBP18_HUMANBioGRID25906440 details
PK3C3_HUMANKEAP1_HUMANBioGRID30126895 details
PK3C3_HUMANMTOR_HUMANBioGRID25533187 details
PK3C3_HUMANATG13_HUMANBioGRID27046250 details
PK3C3_HUMANATGA1_HUMANBioGRID30081750 details
PK3C3_HUMANPGK1_HUMANBioGRID28238651 details
PK3C3_HUMANRACK1_HUMANBioGRID24166503 26549445 details
PK3C3_HUMANDIRA3_HUMANBioGRID24879154 details
PK3C3_HUMANCXA1_HUMANBioGRID24705551 details
PK3C3_HUMANTRI13_HUMANBioGRID31375263 details
PK3C3_HUMANDD19B_HUMANBioGRID29395067 details
PK3C3_HUMANMEX3B_HUMANBioGRID29395067 details
PK3C3_HUMANEPM2A_HUMANBioGRID31758957 details
PK3C3_HUMANNHLC1_HUMANBioGRID31758957 details
PK3C3_HUMANUBP19_HUMANBioGRID32453962 details
PK3C3_HUMANUBP28_HUMANBioGRID32453962 details
PK3C3_HUMANCYLD_HUMANBioGRID32453962 details
PK3C3_HUMANJOS1_HUMANBioGRID32453962 details
PK3C3_HUMANJOS2_HUMANBioGRID32453962 details
PK3C3_HUMANPIPNA_HUMANHPRD8999962 details
PK3C3_HUMANCALM1_HUMANHPRD12925680 details
PK3C3_HUMANCALM2_HUMANHPRD12925680 details
PK3C3_HUMANCALM3_HUMANHPRD12925680 details