Entity Details

Primary name SYN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92777
EntryNameSYN2_HUMAN
FullNameSynapsin-2
TaxID9606
Evidenceevidence at transcript level
Length582
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesSYN2

GO terms

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GOName
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0007268 chemical synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0014069 postsynaptic density
GO:0017156 calcium-ion regulated exocytosis
GO:0030672 synaptic vesicle membrane
GO:0031201 SNARE complex
GO:0042802 identical protein binding
GO:0045202 synapse
GO:0097091 synaptic vesicle clustering
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098978 glutamatergic synapse

Subcellular Location

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Subcellular Location
Cell junction

Domains

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DomainNameCategoryType
IPR001359 SynapsinFamilyFamily
IPR013815 ATP-grasp fold, subdomain 1FamilyHomologous superfamily
IPR016185 Pre-ATP-grasp domain superfamilyFamilyHomologous superfamily
IPR019735 Synapsin, conserved siteSiteConserved site
IPR019736 Synapsin, phosphorylation sitePTMPTM
IPR020897 Synapsin, pre-ATP-grasp domainDomainDomain
IPR020898 Synapsin, ATP-binding domainDomainDomain
IPR028712 Synapsin-2/3FamilyFamily

Diseases

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Disease IDSourceNameDescription
181500 OMIMSchizophrenia (SCZD)A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. Disease susceptibility may be associated with variants affecting the gene represented in this entry.