Entity Details

Primary name PCFT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96NT5
EntryNamePCFT_HUMAN
FullNameProton-coupled folate transporter
TaxID9606
Evidenceevidence at protein level
Length459
SequenceStatuscomplete
DateCreated2005-11-08
DateModified2021-04-07

Ontological Relatives

GenesSLC46A1

GO terms

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GOName
GO:0005542 folic acid binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006879 cellular iron ion homeostasis
GO:0008517 folic acid transmembrane transporter activity
GO:0009986 cell surface
GO:0015078 proton transmembrane transporter activity
GO:0015350 methotrexate transmembrane transporter activity
GO:0015884 folic acid transport
GO:0015886 heme transport
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
GO:0046655 folic acid metabolic process
GO:0051958 methotrexate transport
GO:0098829 intestinal folate absorption
GO:1902600 proton transmembrane transport
GO:1904447 folate import across plasma membrane

Subcellular Location

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Subcellular Location
Apical cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR005829 Sugar transporter, conserved siteSiteConserved site
IPR011701 Major facilitator superfamilyFamilyFamily
IPR020846 Major facilitator superfamily domainDomainDomain
IPR036259 MFS transporter superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00158 Folic acidDrugbanksmall molecule
DB00563 MethotrexateDrugbanksmall molecule
DB00795 SulfasalazineDrugbanksmall molecule
DB08878 AminopterinSwissprotsmall molecule
DB11256 Levomefolic acidSwissprotsmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PCFT_HUMANPCFT_HUMANMINT23601781 details