Entity Details

Primary name PGRP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96PD5
EntryNamePGRP2_HUMAN
FullNameN-acetylmuramoyl-L-alanine amidase
TaxID9606
Evidenceevidence at protein level
Length576
SequenceStatuscomplete
DateCreated2003-11-07
DateModified2021-06-02

Ontological Relatives

GenesPGLYRP2

GO terms

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GOName
GO:0001519 peptide amidation
GO:0005576 extracellular region
GO:0008270 zinc ion binding
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity
GO:0009253 peptidoglycan catabolic process
GO:0016019 peptidoglycan immune receptor activity
GO:0016020 membrane
GO:0016045 detection of bacterium
GO:0019730 antimicrobial humoral response
GO:0032689 negative regulation of interferon-gamma production
GO:0032827 negative regulation of natural killer cell differentiation involved in immune response
GO:0042834 peptidoglycan binding
GO:0045087 innate immune response
GO:0050727 regulation of inflammatory response
GO:0050830 defense response to Gram-positive bacterium
GO:0051701 biological process involved in interaction with host
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Membrane
Secreted

Domains

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DomainNameCategoryType
IPR002502 N-acetylmuramoyl-L-alanine amidase domainDomainDomain
IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteriaDomainDomain
IPR015510 Peptidoglycan recognition proteinFamilyFamily
IPR036505 N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PGRP2_HUMANSGTA_HUMANBioGRID, IntAct32296183 details