Entity Details

Primary name PARK7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99497
EntryNamePARK7_HUMAN
FullNameParkinson disease protein 7
TaxID9606
Evidenceevidence at protein level
Length189
SequenceStatuscomplete
DateCreated2004-12-07
DateModified2021-06-02

Ontological Relatives

GenesPARK7

GO terms

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GOName
GO:0000785 chromatin
GO:0001933 negative regulation of protein phosphorylation
GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus
GO:0003713 transcription coactivator activity
GO:0003729 mRNA binding
GO:0005102 signaling receptor binding
GO:0005507 copper ion binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0006281 DNA repair
GO:0006469 negative regulation of protein kinase activity
GO:0006517 protein deglycosylation
GO:0006954 inflammatory response
GO:0007005 mitochondrion organization
GO:0007265 Ras protein signal transduction
GO:0007338 single fertilization
GO:0008134 transcription factor binding
GO:0008233 peptidase activity
GO:0008344 adult locomotory behavior
GO:0009438 methylglyoxal metabolic process
GO:0010273 detoxification of copper ion
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016532 superoxide dismutase copper chaperone activity
GO:0016570 histone modification
GO:0016605 PML body
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor
GO:0019249 lactate biosynthetic process
GO:0019826 oxygen sensor activity
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019955 cytokine binding
GO:0030073 insulin secretion
GO:0030424 axon
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031397 negative regulation of protein ubiquitination
GO:0032091 negative regulation of protein binding
GO:0032148 activation of protein kinase B activity
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032757 positive regulation of interleukin-8 production
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033182 regulation of histone ubiquitination
GO:0033234 negative regulation of protein sumoylation
GO:0033864 positive regulation of NAD(P)H oxidase activity
GO:0034599 cellular response to oxidative stress
GO:0035065 regulation of histone acetylation
GO:0035973 aggrephagy
GO:0036470 tyrosine 3-monooxygenase activator activity
GO:0036471 cellular response to glyoxal
GO:0036478 L-dopa decarboxylase activator activity
GO:0036524 protein deglycase activity
GO:0036526 peptidyl-cysteine deglycation
GO:0036527 peptidyl-arginine deglycation
GO:0036528 peptidyl-lysine deglycation
GO:0036529 protein deglycation, glyoxal removal
GO:0036530 protein deglycation, methylglyoxal removal
GO:0036531 glutathione deglycation
GO:0042593 glucose homeostasis
GO:0042743 hydrogen peroxide metabolic process
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0044297 cell body
GO:0044388 small protein activating enzyme binding
GO:0044390 ubiquitin-like protein conjugating enzyme binding
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045296 cadherin binding
GO:0045340 mercury ion binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046295 glycolate biosynthetic process
GO:0046826 negative regulation of protein export from nucleus
GO:0048471 perinuclear region of cytoplasm
GO:0050681 androgen receptor binding
GO:0050727 regulation of inflammatory response
GO:0050787 detoxification of mercury ion
GO:0050821 protein stabilization
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0051583 dopamine uptake involved in synaptic transmission
GO:0051881 regulation of mitochondrial membrane potential
GO:0051897 positive regulation of protein kinase B signaling
GO:0051899 membrane depolarization
GO:0051920 peroxiredoxin activity
GO:0060081 membrane hyperpolarization
GO:0060548 negative regulation of cell death
GO:0060765 regulation of androgen receptor signaling pathway
GO:0061727 methylglyoxal catabolic process to lactate
GO:0070062 extracellular exosome
GO:0070301 cellular response to hydrogen peroxide
GO:0070994 detection of oxidative stress
GO:0097110 scaffold protein binding
GO:0098793 presynapse
GO:0106044 guanine deglycation
GO:0106045 guanine deglycation, methylglyoxal removal
GO:0106046 guanine deglycation, glyoxal removal
GO:0110095 cellular detoxification of aldehyde
GO:0140041 cellular detoxification of methylglyoxal
GO:1900182 positive regulation of protein localization to nucleus
GO:1901215 negative regulation of neuron death
GO:1901671 positive regulation of superoxide dismutase activity
GO:1901984 negative regulation of protein acetylation
GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902903 regulation of supramolecular fiber organization
GO:1902958 positive regulation of mitochondrial electron transport, NADH to ubiquinone
GO:1903073 negative regulation of death-inducing signaling complex assembly
GO:1903094 negative regulation of protein K48-linked deubiquitination
GO:1903122 negative regulation of TRAIL-activated apoptotic signaling pathway
GO:1903135 cupric ion binding
GO:1903136 cuprous ion binding
GO:1903168 positive regulation of pyrroline-5-carboxylate reductase activity
GO:1903178 positive regulation of tyrosine 3-monooxygenase activity
GO:1903181 positive regulation of dopamine biosynthetic process
GO:1903189 glyoxal metabolic process
GO:1903197 positive regulation of L-dopa biosynthetic process
GO:1903200 positive regulation of L-dopa decarboxylase activity
GO:1903202 negative regulation of oxidative stress-induced cell death
GO:1903206 negative regulation of hydrogen peroxide-induced cell death
GO:1903208 negative regulation of hydrogen peroxide-induced neuron death
GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903384 negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1903599 positive regulation of autophagy of mitochondrion
GO:1905259 negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
GO:1990381 ubiquitin-specific protease binding
GO:1990422 glyoxalase (glycolic acid-forming) activity
GO:2000157 negative regulation of ubiquitin-specific protease activity
GO:2000277 positive regulation of oxidative phosphorylation uncoupler activity
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:2000825 positive regulation of androgen receptor activity
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endoplasmic reticulum
Membrane raft
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR002818 DJ-1/PfpIDomainDomain
IPR006287 Protein/nucleic acid deglycase DJ-1FamilyFamily
IPR029062 Class I glutamine amidotransferase-likeFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
606324 OMIMParkinson disease 7 (PARK7)A neurodegenerative disorder characterized by resting tremor, postural tremor, bradykinesia, muscular rigidity, anxiety and psychotic episodes. PARK7 has onset before 40 years, slow progression and initial good response to levodopa. Some patients may show traits reminiscent of amyotrophic lateral sclerosis-parkinsonism/dementia complex (Guam disease). The disease is caused by variants affecting the gene represented in this entry.
168600 OMIMParkinson disease (PARK)A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is progressive and usually manifests after the age of 50 years, although early-onset cases (before 50 years) are known. The majority of the cases are sporadic suggesting a multifactorial etiology based on environmental and genetic factors. However, some patients present with a positive family history for the disease. Familial forms of the disease usually begin at earlier ages and are associated with atypical clinical features.

Drugs

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DrugNameSourceType
DB09130 CopperDrugbanksmall molecule

Interactions

80 interactions

InteractorPartnerSourcesPublicationsLink
PARK7_HUMANPARK7_HUMANBioGRID, DIP, HPRD, IntAct12761214 12796482 12851414 12855764 14665635 14713311 15502874 15525661 15894486 15983381 16390825 17331951 18922803 20156966 20304780 24947010 29976090 31353306 details
PARK7_HUMANSAE2_HUMANBioGRID, IntAct15983381 details
PARK7_HUMANUBC9_HUMANBioGRID, IntAct15983381 details
PARK7_HUMANDAXX_HUMANBioGRID, IntAct15983381 32814053 details
PARK7_HUMANANDR_HUMANBioGRID, IntAct17510388 details
PARK7_HUMANBBS1_HUMANBioGRID, IntAct18000879 21097510 32814053 details
PARK7_HUMANMTA1_HUMANBioGRID, IntAct20127688 21368136 details
PARK7_HUMANFADD_HUMANBioGRID, IntAct21785459 details
PARK7_HUMANABL1_HUMANMINT23831022 details
PARK7_HUMANKIF1B_HUMANMINT23831022 details
PARK7_HUMANSODC_HUMANBioGRID, IntAct20406884 24947010 24981860 29128334 31536960 details
PARK7_HUMANGOPC_HUMANBioGRID, IntAct25416956 details
PARK7_HUMANOTUB1_HUMANIntAct26752685 32814053 details
PARK7_HUMANSYUA_HUMANBioGRID, DIP15502874 15935068 25058424 details
PARK7_HUMANPCNA_HUMANUniProt26030842 details
PARK7_HUMANA2MG_HUMANIntAct32814053 details
PARK7_HUMANDYN2_HUMANIntAct32814053 details
PARK7_HUMANTOR1A_HUMANIntAct32814053 details
PARK7_HUMANNUP43_HUMANIntAct32814053 details
PARK7_HUMANSPA2L_HUMANIntAct32814053 details
PARK7_HUMANKRA92_HUMANIntAct32814053 details
PARK7_HUMANLDH6B_HUMANIntAct32814053 details
PARK7_HUMANKKCC1_HUMANIntAct32814053 details
PARK7_HUMANWDR61_HUMANIntAct32814053 details
PARK7_HUMANRN111_HUMANIntAct32814053 details
PARK7_HUMANVPS29_HUMANIntAct32814053 details
PARK7_HUMANIQEC1_HUMANIntAct32814053 details
PARK7_HUMANRN112_HUMANIntAct32814053 details
PARK7_HUMANFYN_HUMANIntAct32814053 details
PARK7_HUMANAP2B1_HUMANIntAct32814053 details
PARK7_HUMANA4_HUMANIntAct32814053 details
PARK7_HUMANHD_HUMANIntAct32814053 details
PARK7_HUMANEFCB6_HUMANBioGRID, HPRD12612053 details
PARK7_HUMANPIAS2_HUMANBioGRID, HPRD11477070 12526767 details
PARK7_HUMANPRKN_HUMANBioGRID15525661 17846173 19229105 24242043 details
PARK7_HUMANB2CL1_HUMANBioGRID21852238 details
PARK7_HUMANBAX_HUMANBioGRID21852238 details
PARK7_HUMANSUMO1_HUMANBioGRID, HPRD12526767 12761214 15983381 details
PARK7_HUMANPINK1_HUMANBioGRID16632486 19229105 details
PARK7_HUMANMAP1B_HUMANBioGRID21645326 details
PARK7_HUMANNDUA4_HUMANBioGRID19822128 details
PARK7_HUMANCASA1_HUMANBioGRID20304780 details
PARK7_HUMANVMAT2_HUMANBioGRID22554508 details
PARK7_HUMANPTEN_HUMANBioGRID19885556 21426932 30631154 31891690 details
PARK7_HUMANHIPK1_HUMANBioGRID16390825 details
PARK7_HUMANCASP8_HUMANBioGRID21785459 details
PARK7_HUMANMAPK5_HUMANBioGRID25383140 details
PARK7_HUMANBIP_HUMANBioGRID29976090 details
PARK7_HUMANKKCC2_HUMANBioGRID31232473 details
PARK7_HUMANKAPCA_HUMANBioGRID31353306 details
PARK7_HUMANMTA2_HUMANBioGRID, IntAct20127688 details
PARK7_HUMANOTU7B_HUMANBioGRID, IntAct21097510 details
PARK7_HUMANTR10A_HUMANIntAct21785459 details
PARK7_HUMANRACK1_HUMANIntAct24947010 details
PARK7_HUMANP5CR1_HUMANIntAct23743200 details
PARK7_HUMANVHL_HUMANBioGRID, IntAct24899725 details
PARK7_HUMANTIA1_HUMANMINT29675578 details
PARK7_HUMANIF4A3_HUMANMINT29675578 details
PARK7_HUMANCHIP_HUMANBioGRID15525661 details
PARK7_HUMANHSP74_HUMANBioGRID15525661 20156966 details
PARK7_HUMANPITX3_HUMANBioGRID21368136 details
PARK7_HUMANCHD4_HUMANBioGRID20127688 details
PARK7_HUMANTRAF6_HUMANBioGRID20634198 details
PARK7_HUMANCLCF1_HUMANBioGRID21097510 details
PARK7_HUMANRF1M_HUMANBioGRID21097510 details
PARK7_HUMANNONO_HUMANBioGRID15790595 18439917 details
PARK7_HUMANM3K5_HUMANBioGRID19293155 20213747 details
PARK7_HUMANNU1M_HUMANBioGRID18626009 19822128 details
PARK7_HUMANNDUS3_HUMANBioGRID19822128 details
PARK7_HUMANP53_HUMANBioGRID18042550 22683601 details
PARK7_HUMANSFPQ_HUMANBioGRID15790595 details
PARK7_HUMANSRBP2_HUMANBioGRID22666465 details
PARK7_HUMANTYDP2_HUMANBioGRID19023331 details
PARK7_HUMANBAG1_HUMANBioGRID20156966 details
PARK7_HUMANPML_HUMANBioGRID22683601 details
PARK7_HUMANU2AF2_HUMANBioGRID26641092 details
PARK7_HUMANSQSTM_HUMANBioGRID29976090 details
PARK7_HUMANGRP75_HUMANBioGRID31767755 details
PARK7_HUMANITPR3_HUMANBioGRID31767755 details
PARK7_HUMANVDAC1_HUMANBioGRID31767755 details