Entity Details

Primary name HELZ2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BYK8
EntryNameHELZ2_HUMAN
FullNameHelicase with zinc finger domain 2
TaxID9606
Evidenceevidence at protein level
Length2649
SequenceStatuscomplete
DateCreated2003-04-30
DateModified2021-06-02

Ontological Relatives

GenesHELZ2

GO terms

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GOName
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004540 ribonuclease activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0019216 regulation of lipid metabolic process
GO:0030374 nuclear receptor coactivator activity
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001900 Ribonuclease II/RDomainDomain
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR022966 Ribonuclease II/R, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR031191 Helicase with zinc finger domain 2FamilyFamily
IPR036236 Zinc finger C2H2 superfamilyFamilyHomologous superfamily
IPR041677 DNA2/NAM7 helicase, helicase domainDomainDomain
IPR041679 DNA2/NAM7 helicase-like, C-terminalDomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
HELZ2_HUMANPPARA_HUMANBioGRID12189208 details
HELZ2_HUMANPPARG_HUMANHPRD16239304 details