Entity Details

Primary name EXOS3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NQT5
EntryNameEXOS3_HUMAN
FullNameExosome complex component RRP40
TaxID9606
Evidenceevidence at protein level
Length275
SequenceStatuscomplete
DateCreated2001-06-01
DateModified2021-06-02

Ontological Relatives

GenesEXOSC3

GO terms

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GOName
GO:0000175 3'-5'-exoribonuclease activity
GO:0000176 nuclear exosome (RNase complex)
GO:0000177 cytoplasmic exosome (RNase complex)
GO:0000178 exosome (RNase complex)
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006364 rRNA processing
GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
GO:0034475 U4 snRNA 3'-end processing
GO:0035327 transcriptionally active chromatin
GO:0043488 regulation of mRNA stability
GO:0043928 exonucleolytic catabolism of deadenylated mRNA
GO:0045006 DNA deamination
GO:0045190 isotype switching
GO:0045830 positive regulation of isotype switching
GO:0071034 CUT catabolic process
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process
GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process
GO:0071049 nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription
GO:0071051 polyadenylation-dependent snoRNA 3'-end processing

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR004088 K Homology domain, type 1DomainDomain
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR026699 Exosome complex RNA-binding protein 1/RRP40/RRP4FamilyFamily
IPR036612 K Homology domain, type 1 superfamilyFamilyHomologous superfamily
IPR037319 Rrp40, S1 domainDomainDomain

Diseases

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Disease IDSourceNameDescription
614678 OMIMPontocerebellar hypoplasia 1B (PCH1B)A severe autosomal recessive neurologic disorder characterized by a combination of cerebellar and spinal motor neuron degeneration beginning at birth. There is diffuse muscle weakness, progressive microcephaly, global developmental delay, and brainstem involvement. The disease is caused by variants affecting the gene represented in this entry.

Interactions

18 interactions

InteractorPartnerSourcesPublicationsLink
EXOS3_HUMANEXOS4_HUMANBioGRID, HPRD, IntAct, MINT15231747 20531386 20531389 21255825 22939629 24981860 26186194 26344197 26496610 28514442 32188736 details
EXOS3_HUMANEXOS5_HUMANBioGRID, HPRD, IntAct, MINT11110791 12419256 15231747 20531389 21255825 22939629 24981860 26186194 26344197 26496610 28514442 32188736 details
EXOS3_HUMANEXOS8_HUMANBioGRID, IntAct, MINT15231747 20531389 21255825 24981860 26186194 28514442 details
EXOS3_HUMANCK5P1_HUMANBioGRID, HPRD, IntAct15231747 details
EXOS3_HUMANEXOS9_HUMANBioGRID, HPRD, IntAct, MINT12788944 20531389 22939629 24981860 26186194 26344197 26496610 28514442 details
EXOS3_HUMANMPH6_HUMANBioGRID, IntAct, MINT20531389 24981860 26186194 26344197 28514442 28877463 details
EXOS3_HUMANTSR2_HUMANBioGRID, IntAct32296183 details
EXOS3_HUMANHBS1L_HUMANBioGRID, IntAct, MINT24981860 26186194 27345150 28514442 details
EXOS3_HUMANA4_HUMANBioGRID21832049 details
EXOS3_HUMANATPD_HUMANBioGRID15231747 details
EXOS3_HUMANOSTM1_HUMANBioGRID32188736 details
EXOS3_HUMANDI3L1_HUMANBioGRID, IntAct, MINT20531386 20531389 23756462 24981860 26186194 26496610 28514442 details
EXOS3_HUMANEXOS2_HUMANBioGRID, IntAct, MINT, UniProt11719186 16396833 17545563 20531389 21255825 22939629 24981860 26186194 26344197 26496610 28514442 32188736 details
EXOS3_HUMANRRP44_HUMANBioGRID, IntAct, MINT20531386 20531389 21255825 details
EXOS3_HUMANEXOS3_HUMANBioGRID, IntAct20531389 21255825 details
EXOS3_HUMANDDX17_HUMANDIP18334637 details
EXOS3_HUMANZCCHV_HUMANDIP21876179 details
EXOS3_HUMANFUBP2_HUMANHPRD15175153 details