Entity Details

Primary name SAE2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UBT2
EntryNameSAE2_HUMAN
FullNameSUMO-activating enzyme subunit 2
TaxID9606
Evidenceevidence at protein level
Length640
SequenceStatuscomplete
DateCreated2004-02-16
DateModified2021-06-02

Ontological Relatives

GenesUBA2

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0008134 transcription factor binding
GO:0016740 transferase activity
GO:0016925 protein sumoylation
GO:0019948 SUMO activating enzyme activity
GO:0031510 SUMO activating enzyme complex
GO:0032183 SUMO binding
GO:0032446 protein modification by small protein conjugation
GO:0033235 positive regulation of protein sumoylation
GO:0044388 small protein activating enzyme binding
GO:0044390 ubiquitin-like protein conjugating enzyme binding
GO:0046982 protein heterodimerization activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000594 THIF-type NAD/FAD binding foldDomainDomain
IPR018074 Ubiquitin-activating enzyme E1, conserved siteSiteConserved site
IPR023318 Ubiquitin activating enzyme, alpha domain superfamilyFamilyHomologous superfamily
IPR028077 Ubiquitin/SUMO-activating enzyme ubiquitin-like domainDomainDomain
IPR030661 SUMO-activating enzyme subunit Uba2FamilyFamily
IPR032426 SUMO-activating enzyme subunit 2, C-terminal domainDomainDomain
IPR033127 Ubiquitin-activating enzyme E1, Cys active siteSiteActive site
IPR035985 Ubiquitin-activating enzymeFamilyHomologous superfamily

Diseases

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Interactions

26 interactions

InteractorPartnerSourcesPublicationsLink
SAE2_HUMANSAE1_HUMANBioGRID, DIP, HPRD, IntAct10187858 10217437 15660128 16189514 17353931 20164921 22863883 22939629 26264872 26344197 26496610 28514442 31515488 9920803 details
SAE2_HUMANUBC9_HUMANBioGRID, HPRD, IntAct12641448 16455490 17353931 17643372 18691969 19250909 21518904 26344197 26496610 28165030 28514442 31575873 9920803 details
SAE2_HUMANPARK7_HUMANBioGRID, IntAct15983381 details
SAE2_HUMANSUMO5_HUMANIntAct25416956 details
SAE2_HUMANSUMO1_HUMANBioGRID, DIP, IntAct10217437 12924945 14673145 20164921 25416956 31515488 32296183 9920803 details
SAE2_HUMANSETX_HUMANUniProt24244371 details
SAE2_HUMANBRX1_HUMANBioGRID, HPRD16169070 details
SAE2_HUMANNEDD8_HUMANBioGRID, HPRD10217437 details
SAE2_HUMANSUMO2_HUMANBioGRID, HPRD16620772 32786267 details
SAE2_HUMANETV4_HUMANBioGRID19307308 details
SAE2_HUMANPAIRB_HUMANBioGRID, HPRD16679534 details
SAE2_HUMANUBC_HUMANBioGRID10217437 28267209 details
SAE2_HUMANCHK1_HUMANBioGRID26296656 details
SAE2_HUMANSAE2_HUMANBioGRID28292943 31575873 details
SAE2_HUMANMEOX2_HUMANBioGRID32296183 details
SAE2_HUMANUBD_HUMANBioGRID31575873 details
SAE2_HUMANERPG3_HUMANBioGRID31722399 details
SAE2_HUMANERCC6_HUMANBioGRID31722399 details
SAE2_HUMANCRCM_HUMANIntAct17353931 details
SAE2_HUMANIKKE_HUMANIntAct17353931 details
SAE2_HUMANHLAB_HUMANIntAct17353931 details
SAE2_HUMANTRAF6_HUMANIntAct17353931 details
SAE2_HUMANPHS_HUMANIntAct20195357 details
SAE2_HUMANSUMO3_HUMANBioGRID, HPRD12924945 16620772 details
SAE2_HUMANRD23B_HUMANBioGRID, HPRD17662948 22863883 details
SAE2_HUMANDERL1_HUMANBioGRID28137758 details