Entity Details

Primary name APC4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UJX5
EntryNameAPC4_HUMAN
FullNameAnaphase-promoting complex subunit 4
TaxID9606
Evidenceevidence at protein level
Length808
SequenceStatuscomplete
DateCreated2003-10-03
DateModified2021-06-02

Ontological Relatives

GenesANAPC4

GO terms

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GOName
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005829 cytosol
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007049 cell cycle
GO:0007096 regulation of exit from mitosis
GO:0019903 protein phosphatase binding
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0034399 nuclear periphery
GO:0045842 positive regulation of mitotic metaphase/anaphase transition
GO:0051301 cell division
GO:0070979 protein K11-linked ubiquitination
GO:1901990 regulation of mitotic cell cycle phase transition

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR017169 Anaphase-promoting complex subunit 4, metazoaFamilyFamily
IPR024789 Anaphase-promoting complex subunit 4FamilyFamily
IPR024790 Anaphase-promoting complex subunit 4 long domainDomainDomain
IPR024977 Anaphase-promoting complex subunit 4, WD40 domainDomainDomain
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
APC4_HUMANCDC27_HUMANBioGRID, DIP, IntAct10922056 12956947 14657031 16364912 18471975 20360068 20686030 21043528 21241890 21335556 21336306 21926987 22193957 22939629 23007648 23007861 23078409 24464857 25043029 25383541 25490258 25673878 25723520 25750436 26083744 26344197 26496610 26811472 26960431 27114510 29549242 32076268 32152539 details
APC4_HUMANCDC16_HUMANBioGRID, DIP, IntAct12956947 20360068 21335556 21926987 22939629 23078409 25043029 25490258 25673878 25723520 26083744 26344197 26496610 28514442 29549242 details
APC4_HUMANCDC20_HUMANBioGRID, DIP, IntAct, MINT18471975 20360068 21335556 21336306 21926987 23007648 23078409 23160376 23288039 23443559 24151075 24464857 25043029 25306918 25383541 25673878 25750436 26811472 26986935 27097363 27114510 27939943 28404789 32152539 details
APC4_HUMANMD2L1_HUMANBioGRID, DIP, MINT21335556 21926987 23007648 23160376 23288039 24151075 25383541 25673878 25750436 26986935 27097363 27939943 32152539 details
APC4_HUMANFZR1_HUMANBioGRID, DIP, IntAct12956947 23078409 25043029 25673878 26083744 28514442 details
APC4_HUMANANC2_HUMANBioGRID, DIP10922056 12956947 22939629 23078409 25043029 25490258 25673878 26083744 26344197 27120157 29549242 34079125 details
APC4_HUMANFBX5_HUMANBioGRID, DIP16921029 25750436 26083744 details
APC4_HUMANAPC11_HUMANBioGRID, DIP12956947 21926987 23078409 25043029 25490258 26083744 29549242 details
APC4_HUMANUBE2S_HUMANBioGRID25306923 details
APC4_HUMANUBC9_HUMANBioGRID29549242 details
APC4_HUMANMD2BP_HUMANBioGRID32152539 details
APC4_HUMANBUB1B_HUMANBioGRID, DIP, IntAct, MINT20360068 21336306 21926987 23007648 23160376 23288039 24151075 24464857 25383541 25669885 25673878 25750436 26986935 27097363 27939943 28404789 31911655 details
APC4_HUMANAPC16_HUMANBioGRID, DIP, IntAct20360068 23078409 25043029 25490258 26083744 26344197 29549242 details
APC4_HUMANAPC1_HUMANBioGRID, DIP, IntAct11076961 12956947 20360068 22939629 23078409 24464857 25043029 25490258 26083744 26344197 29549242 details
APC4_HUMANAPC5_HUMANBioGRID, DIP, IntAct12956947 20360068 22939629 23078409 25043029 25490258 26083744 26344197 29549242 details
APC4_HUMANCDC23_HUMANBioGRID, DIP, IntAct12956947 20360068 22939629 23078409 25043029 25490258 26083744 26344197 26496610 29549242 details
APC4_HUMANCDC26_HUMANBioGRID, DIP, IntAct20360068 23078409 25043029 25490258 25723520 26083744 26344197 29549242 details
APC4_HUMANAPC13_HUMANBioGRID, DIP, IntAct20360068 22939629 23078409 25043029 25490258 26083744 28514442 29549242 details
APC4_HUMANKI18A_HUMANBioGRID, MINT23288039 details
APC4_HUMANNEK2_HUMANBioGRID, MINT23288039 25673878 25750436 29863498 details
APC4_HUMANBUB3_HUMANBioGRID, MINT21926987 23007648 23160376 23288039 24151075 24464857 27097363 details
APC4_HUMANAPC7_HUMANBioGRID, DIP, MINT12956947 21926987 22939629 23078409 23288039 25043029 25490258 26083744 26344197 26986935 28404789 29549242 details
APC4_HUMANAPC15_HUMANBioGRID, DIP, IntAct21926987 23007861 23078409 23160376 25043029 25490258 26083744 26496610 29549242 details
APC4_HUMANAPC10_HUMANBioGRID, DIP12956947 22939629 23078409 25043029 25490258 25750436 26083744 26344197 27509861 29549242 details
APC4_HUMANSH3K1_HUMANBioGRID19531213 details
APC4_HUMANCCNB1_HUMANBioGRID20733055 21336306 25750436 details
APC4_HUMANAPC4_HUMANBioGRID21336306 24464857 26083744 29549242 details
APC4_HUMANCCNA2_HUMANBioGRID21336306 25669885 25750436 details
APC4_HUMANCSN2_HUMANBioGRID19535905 details
APC4_HUMANTRI33_HUMANBioGRID23160376 details
APC4_HUMANPHF8_HUMANBioGRID23979597 details
APC4_HUMANDCPS_HUMANBioGRID25043029 details
APC4_HUMANCDK1_HUMANBioGRID25750436 details
APC4_HUMANPSMD8_HUMANBioGRID26986935 details
APC4_HUMANNUP98_HUMANBioGRID27097363 details
APC4_HUMANHXD13_HUMANBioGRID27097363 details
APC4_HUMANLNP1_HUMANBioGRID27097363 details
APC4_HUMANHHEX_HUMANBioGRID27097363 details
APC4_HUMANMXI1_HUMANBioGRID28404789 details
APC4_HUMANPP2AA_HUMANBioGRID28404789 details
APC4_HUMANKI18B_HUMANBioGRID29549242 details