Entity Details

Primary name RRP44_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y2L1
EntryNameRRP44_HUMAN
FullNameExosome complex exonuclease RRP44
TaxID9606
Evidenceevidence at protein level
Length958
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesDIS3

GO terms

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GOName
GO:0000175 3'-5'-exoribonuclease activity
GO:0000176 nuclear exosome (RNase complex)
GO:0000177 cytoplasmic exosome (RNase complex)
GO:0000178 exosome (RNase complex)
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006364 rRNA processing
GO:0016020 membrane
GO:0016075 rRNA catabolic process
GO:0043488 regulation of mRNA stability
GO:0043928 exonucleolytic catabolism of deadenylated mRNA
GO:0071034 CUT catabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001900 Ribonuclease II/RDomainDomain
IPR002716 PIN domainDomainDomain
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR022966 Ribonuclease II/R, conserved siteSiteConserved site
IPR029060 PIN-like domain superfamilyFamilyHomologous superfamily
IPR033770 Exosome complex exonuclease RRP44, S1 domainDomainDomain
IPR033771 Rrp44-like cold shock domainDomainDomain
IPR041505 Dis3-like cold-shock domain 2DomainDomain

Diseases

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Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
RRP44_HUMANEXOSX_HUMANBioGRID, HPRD, IntAct, MINT15231747 20531386 21255825 23756462 26344197 details
RRP44_HUMANEXOS8_HUMANBioGRID, HPRD, IntAct, MINT11719186 15231747 20531386 details
RRP44_HUMANNTM1A_HUMANBioGRID, IntAct15231747 details
RRP44_HUMANZBT17_HUMANBioGRID, HPRD, IntAct15231747 details
RRP44_HUMANEXOS9_HUMANBioGRID, HPRD, MINT11719186 12788944 20531386 26344197 details
RRP44_HUMANNDKB_HUMANIntAct17353931 details
RRP44_HUMANEXOS3_HUMANBioGRID, IntAct, MINT20531386 20531389 21255825 details
RRP44_HUMANEXOS5_HUMANBioGRID, HPRD, MINT11719186 20531386 details
RRP44_HUMANEXOS4_HUMANBioGRID, HPRD, MINT11719186 20531386 26344197 details
RRP44_HUMANEXOS7_HUMANBioGRID, HPRD, MINT11719186 20531386 26344197 details
RRP44_HUMANEXOS2_HUMANBioGRID, HPRD, MINT11719186 20531386 26344197 details
RRP44_HUMANCOPZ1_HUMANBioGRID, IntAct27173435 unassigned1312 details
RRP44_HUMANSARNP_HUMANBioGRID, IntAct27173435 unassigned1312 details
RRP44_HUMANCDK5_HUMANBioGRID, IntAct27173435 unassigned1312 details
RRP44_HUMANSEPT7_HUMANBioGRID, IntAct27173435 unassigned1312 details
RRP44_HUMANSCYL2_HUMANBioGRID, IntAct27173435 unassigned1312 details
RRP44_HUMANPRCC_HUMANBioGRID, IntAct27173435 unassigned1312 details
RRP44_HUMANSEP11_HUMANBioGRID, IntAct27173435 unassigned1312 details
RRP44_HUMANCHRD1_HUMANBioGRID, IntAct27173435 unassigned1312 details
RRP44_HUMANDRG1_HUMANBioGRID, IntAct27173435 unassigned1312 details
RRP44_HUMANTCP4_HUMANBioGRID, IntAct27173435 unassigned1312 details
RRP44_HUMANSHLB1_HUMANBioGRID, IntAct27173435 unassigned1312 details
RRP44_HUMANDISC1_HUMANIntAct31413325 details
RRP44_HUMANMTREX_HUMANBioGRID, HPRD11719186 20531386 details
RRP44_HUMANAICDA_HUMANBioGRID21255825 details
RRP44_HUMANRN126_HUMANBioGRID26508657 details
RRP44_HUMANTULP3_HUMANBioGRID33187986 details
RRP44_HUMANPALS2_HUMANHPRD11719186 details
RRP44_HUMANEXOS6_HUMANHPRD11719186 details